<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12584

Description mediator of RNA polymerase II transcription subunit 21-like
SequenceMGSWSSMAVRGWSTRLLLVWGDGGDGLFGCLVEQLVVRRRLCVCVEQQQPWRAVSGGTRKKMTGVAASMATLSSNSLTRLGCNCDWSISEKDNYKNIGRIHKVDIISQLQEQVNTIAALAFNTFGTLQRDAPPVRLSPNYPEPPPANPTEDAANVAEQPKQMSAAFVKAAKQFDALVAALPLSDGGEEAQLKRIAELQAESDVVGQELQKQLEAAEKELKQVQELFNQATDNCLNLKKPE
Length240
PositionMiddle
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.05
Grand average of hydropathy-0.336
Instability index56.34
Isoelectric point5.66
Molecular weight26239.56
Publications
PubMed=23773524

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12584
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.85|      32|      43|     111|     142|       1
---------------------------------------------------------------------------
   69-   96 (31.83/16.48)	.....MATLSSNSLTRLGCNC..DwSISEKDNYKN
  111-  142 (54.88/32.70)	EQVNTIAALAFNTFGTLQRDA..P.PVRLSPNYPE
  157-  188 (42.14/23.73)	EQPKQMSA.AF.VKAAKQFDAlvA.ALPLSDGGEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.98|      19|      27|     190|     210|       2
---------------------------------------------------------------------------
  190-  210 (25.47/24.28)	QLKRIAEL..QAESDVVgqELQK
  218-  238 (27.51/18.19)	ELKQVQELfnQATDNCL..NLKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12584 with Med21 domain of Kingdom Viridiplantae
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