<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12578

Description U-box domain-containing protein 35-like
SequenceMPAFNYIRSPSRIKRALSWKETFITEEDWQSMEENDISKMEGQGTMQSPPSSVVAIAISGNKNSKYVVKWALDKFVPEGETRFMLLHVRPEITAVPTPMGNLIPIAQVREDVADAFRKEVELQASEKLLPYKTMFIRRKVQVGVVQIESNDVVNAIAGVVSKCSINKLVIGTSTPGLFSRGRNLSASISETAPTFCTVYAVSKGKLSSVRPSSYENNGAVTDDSSDTSGSSNNSTGHSFSSQAERTDHSSTSPASYSHLYSPSRKLQRYQAKSPTHHALQTLLHKRTNIGETIQSRSSSIEIGEAFQALSIKNNTKRANLSEVIHPRAMTIATGEAEDDKSCYFSSSGITDPNSLNSSFKKAKVDNQQWSTSQSSNSDAPTDSSSGSQVNINYDLEKLRIELRHIQGMYAIAQTEAIDASRKLNEFQKLRVDEANKLMEINLKEEEAKELAEQEKLKCEAAKKEADYAMECAEREVEKRRAAESIANREARTKEKLEKSLVLPLHHYQEFTWEEIVTASSSFSEDLKIGMGSYGMVYKCYLHHTSAAVKVLHSAEAHRTKQFQQELEILSTIHHPHLLILLGACPERGCLVYEYMENGSLEDRLIRKNNTPPLTWFDRVRIAWEVASALVFLHNTKPKPIIHRDLKPANILLDHNLVSKIGDVGLSTMVQLDSSSAMTAYKDTSPVGTLCYIDPEYQRTGLVSTKSDVYAFGMVILQLLTAKRAIALAHMVEMAIEDDNLVELLDQEAGEWPIEETKELAVLAIKCTELRRRDRPDLKDEVLPALERLKEVADRARDLIYIQSPSPSHFKCPLLKEVMQDPCVAADGYTYDRKAIESWLKDNDHSPVTNSPLPHKHLLPNYTLLSAIKEWKSGKH
Length875
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.06
Grand average of hydropathy-0.459
Instability index51.15
Isoelectric point6.35
Molecular weight97945.87
Publications
PubMed=23773524

Function

Annotated function Functions as an E3 ubiquitin ligase. 
ECO:0000256	ARBA:ARBA00003861
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12578
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.57|      27|      30|     408|     436|       1
---------------------------------------------------------------------------
  394-  415 (20.54/10.06)	.......DLEKLRIElrHIQGMYAIAQTE
  418-  444 (42.05/32.80)	DASRKLNEFQKLRVD..EANKLMEINLKE
  445-  463 (21.98/ 7.77)	EEAKELAEQEKLKCE..AAKK........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.93|      21|     294|     273|     315|       2
---------------------------------------------------------------------------
  285-  305 (35.97/51.74)	KRTNIGETIQSRSSSIEIGEA
  316-  336 (36.96/ 8.49)	KRANLSEVIHPRAMTIATGEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.99|      27|     294|     363|     389|       3
---------------------------------------------------------------------------
  338-  364 (45.83/30.58)	DDKSCYFSSSGITDPNSLNSSFKKAKV
  365-  391 (46.16/30.86)	DNQQWSTSQSSNSDAPTDSSSGSQVNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.47|      40|      59|     173|     213|       6
---------------------------------------------------------------------------
  173-  213 (62.42/34.66)	STPGLFSRGRNLSASISETAPTFCTVYAVSKgKLSSVRPSS
  234-  273 (69.04/34.66)	STGHSFSSQAERTDHSSTSPASYSHLYSPSR.KLQRYQAKS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12578 with Med32 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LNSSFKKAKVDNQQWSTSQSSNSDAPTDSSSGSQ
2) RPSSYENNGAVTDDSSDTSGSSNNSTGHSFSSQAERTDHSSTSPASYSHLYSPSRKLQRYQAKSPTHHALQTLLHKRTNIGETIQSRS
355
210
388
297










Molecular Recognition Features






MoRF SequenceStartStop




NANANA