<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12572

Description mediator of RNA polymerase II transcription subunit 15a isoform X2
SequenceMDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQANATNLQQNQLIGQQNTMPDVQQRIVGQQNNYSSLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSNSTAQTGNANAADLQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVVFLRLNKHDIQPSHKEKLLQVEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKSGTPLLSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSSSVNDSFWQLHCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDEGVDPSAVASATEGGEGITVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1353
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.754
Instability index71.43
Isoelectric point9.41
Molecular weight148741.92
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12572
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     249.99|      55|      55|     469|     523|       1
---------------------------------------------------------------------------
  282-  326 (55.70/ 8.42)	..QQSMMQ.shmQQQQ...QQ.QPQDQQQQQQQ......QQQQQ.QQQ...QNLLQP..TQIQS
  460-  515 (84.89/16.86)	.G..SQSNiagvQQQQLTGSQ.QPGNSGVPSNQHPIHMLQQSKV.PLQ...QQMLQGGTTLLPS
  516-  568 (56.69/ 8.70)	QGQQSQSQ..paQQQMMSQSQsQPGQL.....QPPLG.LQQQTN.QLQremQQRLQTSGPLL..
  713-  763 (52.70/ 7.55)	PSMQLQ......QPQSLDGQG.NPPMQPV...QGSMAAMQQNNItNLQ...HNSLSGVPTISNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     296.02|      43|      43|     764|     806|       2
---------------------------------------------------------------------------
  109-  164 (41.93/ 7.00)	QNPINNSMQPNAAS.SG..QnalG....PGSHSM...QSQVNSQAQQlpvpmvanQTQTRQpllQ....Q
  217-  265 (49.47/ 9.78)	QNSVGNAIGQGMPSNMV......A....NSQRQMqgrQQVVSQQQQQ........QSQTSQ...QylyqQ
  355-  396 (42.22/ 7.11)	QS..TQSV.LHQRS.....Q...SvmrqQQAPML...HQQQSAMLQQ.........PILPA...Q..qhQ
  764-  806 (69.40/17.13)	QQHMVNTVQSGSTVDLG..Q...G....NSLNSL...QQVATGSLQQ........NPVNSP...Q....Q
  815-  846 (42.59/ 7.25)	QSG.TNPVQA....NLGslQ...P....NS.NVL...QQ....SL...........PKQHE...Q....Q
  919-  957 (50.42/10.13)	QQSVGQRVGSHHP.QLK..P...G....ISSPQI...HQALSPQVTQ........HP..SP...Q.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.70|      16|      41|     397|     415|       3
---------------------------------------------------------------------------
  328-  346 (19.83/ 6.54)	QQTMMQPSSMQStslSNLQ
  859-  874 (28.88/ 7.06)	QRQMQQQLYNRQ...QFMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.28|      28|      28|     397|     424|       4
---------------------------------------------------------------------------
  397-  424 (50.73/18.51)	QQQLIAQQANATNLQQNQLIGQQNTMPD
  426-  453 (47.32/16.70)	QQRIVGQQNNYSSLQQQQLLNQQNNLQN
  629-  647 (29.24/ 7.10)	YQKIAAK......VQQHDSLPQR...PQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     165.99|      34|      38|     982|    1015|       5
---------------------------------------------------------------------------
  972- 1005 (55.09/27.52)	TP....LLSASSPF......V.VPSPSTPLAPSPMPGDSEKVSAG
 1006- 1040 (35.43/15.16)	LA....LHTTAGNImhqqatV.ASAPAQSLAIG.TPG....ISAS
 1043- 1082 (34.69/14.70)	LAeftsLDGTHANV....saA.VSGKSSVEQPLERLMKVVKNMSP
 1083- 1116 (40.77/18.52)	KA....LNSSVSDI......SsVVSMIDRIAGS.APGNGSRAAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.82|      18|      21|    1265|    1282|       8
---------------------------------------------------------------------------
 1265- 1282 (33.59/27.80)	VPANYPNCSPVLLDKFPV
 1284- 1301 (29.23/23.08)	VSKEYEDLSMKAKSRFSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.43|      13|      21|      72|      88|       9
---------------------------------------------------------------------------
   72-   88 (15.33/25.30)	LKKIAVrfeeKIYTAAT
   94-  106 (22.09/18.01)	LRKISL....KMLTMET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.07|      19|      23|     667|     685|      13
---------------------------------------------------------------------------
  667-  685 (33.19/15.79)	FLRLNK.HDIQPSHKEKLLQ
  693-  712 (30.88/14.18)	FLNSNRpRKPTPPLQGQLPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12572 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQ
2) LSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHT
3) MDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDS
4) SFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKS
5) SLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSNSTAQTGNANAADLQEEV
6) TSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQ
97
975
1
691
438
257
252
1010
45
970
610
404










Molecular Recognition Features






MoRF SequenceStartStop




NANANA