<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12566

Description mediator of RNA polymerase II transcription subunit 15a isoform X3
SequenceMDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQANATNLQQNQLIGQQNTMPDVQQRIVGQQNNYSSLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVVFLRLNKHDIQPSHKEKLLQVEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKSGTPLLSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSSSVNDSFWQLHCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDEGVDPSAVASATEGGEGITVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1324
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.754
Instability index71.06
Isoelectric point9.38
Molecular weight145767.76
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12566
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     281.20|      56|      56|     469|     524|       2
---------------------------------------------------------------------------
  389-  431 (47.77/ 7.51)	ILPAQ......QH.QQQQLI.AQ.QANATN...........LQQNQ...LIGQQNTMPDV...QQRIVG...
  460-  511 (75.54/17.09)	.....GSQSNIAGvQQQQLTGSQ.QPGNSG...........VPSNQHPIHMLQQSKVPLQ...QQMLQGGTT
  512-  566 (69.50/15.01)	LLPSQGQQSQSQPaQQQMMSQSQsQPGQL................QPPLG.LQQQTNQLQremQQRLQTSGP
  780-  823 (43.74/ 6.12)	V..DLGQGNSLNSlQQANL.GSL.QP.NSN...........V.........LQQS.LPKQ.heQQMLQNQQ.
  917-  978 (44.66/ 6.44)	LSPQVTQHPSPQI.DQQNMLASL.T..KSGtpllsasspfvVPSPSTP...LAPSPMPGD...SEKVSAGLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     173.22|      42|      55|     241|     282|       3
---------------------------------------------------------------------------
  196-  242 (43.07/ 8.47)	MPNVMGQNANLQTMQNMQNVGQN...SVGNaigQGMPSNMVANSQR..............qmQG
  243-  300 (71.60/19.95)	RQQVVSQQQQQQSQTSQQYLYQQ...QMHH...QMMKQKFQPGSTQqsmmqshmqqqqqqqpQD
  301-  347 (58.54/14.70)	QQQQ.QQQQQQQQQ.QQQNLLQPtqiQSSQ...QTM...MQPSSMQ.........stslsnlQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.21|      45|      47|      80|     124|       4
---------------------------------------------------------------------------
   44-   91 (52.07/24.88)	DSR....QRIVNKI..METlKRHLPV.SgqEGVQelKKIAVRFEEKIYTAATSQQ
   92-  136 (75.32/39.75)	DYL....RKISLKMLTMET.KSQNPI.N..NSMQ..PNAASSGQNALGPGSHSMQ
  137-  174 (33.82/13.22)	SQVnsqaQQLPVPMVANQT.QTRQPLlQ..QNIQ..NNMASTG............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     279.97|      62|     109|     588|     649|       5
---------------------------------------------------------------------------
  568-  638 (83.87/37.42)	LQQQNVM......EQQ.kqlyqpqraaPEASST......SL..DSTAQTGNANAAD.........LQEEVYQ.......KIKSMREMYL...................PELNDLYQKIAAK
  639-  719 (62.16/25.31)	VQQHDSL......PQRP.........qTEQIEKlkvfkmTL..ERVVVFLRLNKHD.........IQP..............SHKEKLLqvekhisfflnsnrprkptPPLQGQLPQPSMQ
  720-  773 (66.80/27.89)	LQQPQSLdgqgnpPMQP........................vqGSMAAMQQNNITN.........LQHNSLS.......GV...........................PTISNSQQHMVNT
  845-  914 (67.14/28.09)	.QQQQAK......QQQ...........TAQLPA..........HQMSQLHQMNDANdlkmrqqmgLKPGVLQqqqsvgqRVGSHHPQLK...................PGISSPQIH....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.57|      22|      51|    1213|    1234|       7
---------------------------------------------------------------------------
 1213- 1234 (38.69/18.43)	LSPNLKSQYASAQMSPIQPLRL
 1262- 1283 (36.87/17.22)	LSMKAKSRFSVSLRSLSQPMTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.02|      14|      27|    1031|    1044|       8
---------------------------------------------------------------------------
 1031- 1044 (23.40/15.19)	VSGKSSVEQPLERL
 1060- 1073 (19.17/10.87)	VSDISSVVSMIDRI
 1124- 1137 (21.45/13.20)	VSSSSSVNDSFWQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12566 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQ
2) LSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHT
3) MDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDS
4) SFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKS
5) SLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEV
6) TSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQ
97
946
1
694
438
257
252
981
45
941
613
404










Molecular Recognition Features






MoRF SequenceStartStop




NANANA