<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12564

Description mediator of RNA polymerase II transcription subunit 23
SequenceMLRAPTPTSHSNQATPEMEQPPPPPPPPQLRSSSSSVFRSHHHHFHPSRPAILDLFNLYLGLKNSGQKSDDSIREPPNKTQKRVTALNRELPPRNEQFVLDFGQLQSQFADQEQLRAVAESVLISLVIQCSSHAPHAEFLLFAICSLSSIGYINWDTFLPSLLSSVSSTEISASQGNQPSGAVSSANLTQSGLLPSSAAVASTSNFHSSNPASPLPTVHGIGSPVQSAAEPSSSAALSPMKSSDINGTSQQSIAKVNLLTRDSAASSLRQICCKIILSGLDSSLKPGTHAEVFHHMLNWLIYWDQKLHGVDEFDSAKYWKPDKALIEWLHSCLDVIWLLVENDKCRIPFYELLRSGLQFLENIPDDEALFTLILEIHRRRDMMAMHMQMLDQHLHCPTFGTPRLLPQATANSSGEAVTNMRYSPITYPSVLGEPLHGEDLAASIQKGSLDWERALRILKHALCNTPSPDWWRRVLLVAPCHRLHAQAPTPGAVFTSEMVCEAAIERIVELLKLTNSEINCWQEWLIFSDIFFFLVKSGCVDFVEFVDKLVLRLQEGDQQILRTNHVTWLLAQIIRVELVMNALNTDSRKVETTRKILSFHKEEKSSDPNNPQSILLDFISSCQNLRIWTLNTATREYLNNEQLQKGKQIDEWWRQVNKGERMMDYMNLDDRSIGMFWVVSYTMAQPACETVMHWLTSAGVTELLPGPNLQSNERLMVMREVSPLPISLLSGFSTNLCLKLAFQMEESMFSGQAVPSIAVVETYCRLMLISPHSLFRSLLTHLTSRNPTTLTKPGNTILVFEILNYRFLSLYRYQGKSKTLMYDVTKMISTLKGKRGDHRIFRLAENLCMNLILSLRDFFYVKREGKGPTEFTETLNRITIVTLAIIIKTRGIGEFDQLLYLQTMLEQILATSQHTWSEKTLRYFPSILRDALSGRMDKRGLAIQAWQQAETTVINQCTQLLSPSADPTYVMTYINHSFPQHRQYLCAGAWILMHGHPENINCINLGRVLREFSPEEVTANIYTMVDVLLHHIHLELQRGHPLQDLMLKACGNLSIFIWTHELLPPDILLLALIDRDDNPHALRIVINLLDSKELQQRVKLYLINRGPPEHWLSSGPFKRVELQKALGNYLSWKERYPTFFDDIAARLLPIIPLIIYRLVENDAMDAADRALQVYSTFLHYYPLNFTFVRDILAYFYGHLPGKLILRILNILDIKKIPFSESFPQHINSSNAAMCPPLDYFATLLLGLVKHVIPALNNSSKCAAMGDFANNSMRAPHGKIQATSQPGPTNSSEVQKPYYQMQDPGTFTQLTLETAVIELLSLPVCPSQIVSALVQIVVHIQPTLVQSSNGLHGAPGSSGQGSILPTSPSGGSSDSLGATRTTPSVSGMNTSNFVSRSGYTCQQLSCLLIQACGLLLAQLPPEFHVQLYVEAAHIIKESWWLTDAKRSVGELESAVSYALLDPTWAAQDNTSTAIGTLS
Length1477
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.08
Grand average of hydropathy-0.102
Instability index48.23
Isoelectric point6.50
Molecular weight165657.46
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12564
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.44|      43|      85|    1244|    1291|       1
---------------------------------------------------------------------------
 1244- 1291 (61.94/53.98)	LLGLVKHVIPALNNSSKcAAMGdfANNSmrAPHGKIQATSQPGPTNSS
 1332- 1374 (76.50/46.12)	LVQIVVHIQPTLVQSSN.GLHG..APGS..SGQGSILPTSPSGGSSDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.83|      21|      84|     761|     797|       2
---------------------------------------------------------------------------
   33-   53 (40.53/10.12)	SSSSVFRSHHHHFHPSRPAIL
  770-  790 (36.30/37.75)	SPHSLFRSLLTHLTSRNPTTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.93|      16|      16|     176|     191|       4
---------------------------------------------------------------------------
  167-  183 (22.27/10.51)	SS.TEISASqGNQPSG.AV
  184-  200 (21.75/10.08)	SS.ANLTQS.GLLPSSaAV
  201-  218 (17.90/ 6.86)	AStSNFHSSnPASPLP.TV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.16|      66|     224|     622|     694|       6
---------------------------------------------------------------------------
  622-  694 (112.77/98.00)	CQNLrIWTLntatREYLNNEqlQKGKQIDEWWRQVNKGERMMDYMNLDDRSIGMFWVVSY..TMAQPACETVMH.W
  848-  916 (105.40/72.06)	CMNL.ILSL....RDFFYVK..REGKGPTEFTETLNRITIVTLAIIIKTRGIGEFDQLLYlqTMLEQILATSQHtW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.66|      14|      17|     448|     463|       7
---------------------------------------------------------------------------
  448-  463 (23.58/22.14)	SLDWERalRILKHALC
  467-  480 (31.08/21.82)	SPDWWR..RVLLVAPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     252.31|      80|     816|     335|     427|      10
---------------------------------------------------------------------------
  335-  427 (115.00/120.41)	VIWLLVENDKCRIPfYELLRSGLQFLENIPDDealFTLILEI......HRRRDMMAMHMQMLDQHlHCPtFGTPrlLPQaTANSSGEAVTnmrySPITY
 1154- 1239 (137.31/94.41)	IIYRLVENDAMDAA.DRALQVYSTFLHYYPLN...FTFVRDIlayfygHLPGKLILRILNILDIK.KIP.FSES..FPQ.HINSSNAAMC....PPLDY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12564 with Med23 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MLRAPTPTSHSNQATPEMEQPPPPPPPPQLRSSSSSVFRSHHH
1
43










Molecular Recognition Features






MoRF SequenceStartStop




NANANA