<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12561

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVSRTAEESYATLNELVEKCKSSDLSDSEKKIGILKYIVKTQQRMLRLNVLSKWCQQVPLIQYCQQLASTLSSHETCFTQAADSLFFMHEGLQQARAPIYDVPSAVEVLLTGSYERLPKCIEDVGLQSVLNDNQQKPALKKLDALVRSKLLEVSLPKDITEVKVSDGTVLLRVDGEFKVLVTLGYRGHLSMWRILHMELLVGERSGPMKLDDFRRHALGDDLERRMAAADNPFMTLYSILHELCVALVMDTVIRQVQTLRHGRWKDAIRFELISDGSTGQGGSSGSAQISQDGESDSASLRTPGLKILYWLDLDKNSSTSEIGTCPFIKIEPGLDLRIKCLHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLRVICCNRYTRLLEIYKELEKNGQICRVPGDVQLQCHVEDMLADSRKKDNKFDSREYQGQEVLRVRAFGSSFFTLAINIRNGHFILHSSKNIISSLVVVECEEALNQRSMSAADAFISLRSKSILHLFACIGRFLGLEVFEHGSAAVKVPKSISCGINLLLMGFPECGSSYFLLMELDKDFKPVFKLLESQSDTPEKAQSLVDLSNVVRVKTVDIGRMQICEDELNLSLLNSKKLLSILPSDGGSHQTSENSLLADFSLEGSIVSSSAPSTFCSIVDEIFELEKGSSVPSFSGQIPPSTFGASPASHLGSGVANYQSLKVGTLSPKWDRGTGNYSSSMYKGVIQSGSAGSLATAPGRSQTVKKLTASKSEQDLTSLRSPHSAGAGSYTSLDEDQLTVSTNRSARLLSPPQRACPPASALSGKASAPRNSAAGTVPVGFRTSESNSLVLSPGSQAIDSATCPQSEQDAASRYNILPRKRTLSDLLDSLPSLQAMESNEGSYKRRKLVESAGTHLPKSLMLISSDISGKAEEYSYGSLIAEANKGNAPSSIYVSSLLHVVRHCSLCIKHARLTSQMEALEIPYVEEVGLRSASSNLWFRVPFARDDAWQHICLRLGRPGSMYWDVKINDQHFQDLWELQKGSNSTPWGSGVRIANTSDADSHIRYDSEGVVLSYYSVNADSIKKLVADIQRLSNARTFARGMRKLLGARADEKFEDSNANSENKALAAIKGASDATDRISEQMRKQFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAAPVSGVPGVTAPMSSVAKQTSYVPSLPSNVSTRINQPASGPGVNPVSVTVGALGTHHPSAAMLAAAAAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKKFAVDMRCFAGDQVWLQPATPPKGGPEVGGSLPCPQFRPFIMEHVAQELNGIDSNFTGSQQAVGLTNSNSLNAGSQLPAANTNRTNLSNSTGLVRPANAVTGFNRTANGLPSASNLAVVNAGMPLRRPPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVISVKRFHQSQQQQQQNPGSAQEELTQAEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQVQGGDMVPTQKSRIELCLENHAGCSIDGSSENTSASKSNIHYDRAHNSVDFALTVVLDHAHIPHINAAGGAAWLPYCVSVRLRYAFGENPNVLFLGMEGSHGGRACWLRVDDWERCKQRVARTVEVNGNSAGDVNQGRLRVVADSVQRTLHAYLQGLRDGGGVAAGIGS
Length1798
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.145
Instability index45.25
Isoelectric point7.52
Molecular weight195148.82
Publications
PubMed=23773524

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12561
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     600.76|     160|     163|     878|    1040|       1
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  665-  850 (183.88/105.15)	LEKGS.SVPSFSG.QIPPSTFGaspashlgsgvanyqslkvgtlspkwdRGTGNYSSsmyKGVIQsgSAGSlaTAPGRSQTVKKLTA..SKSEQ.DLTS...LRSPHSA....GAGS...YTSldeDQLTVSTN.....RSARLLSPP.QRACPPASALSGKASAPRNsAAGTVP.vgF.R.TSESNSLVLS...PG.SQAIDSATCPQSEQDA..
  851- 1018 (244.68/149.95)	.ASRYNILP.....RKRTLSD................lldslpslqameSNEGSYKR...RKLVE..SAGT..HLPKSLMLISSDIS..GKAEEYSYGS...LIAEANK....GNAPSSiYVS...SLLHVVRHCSLCIKHARLTSQM.EALEIPYVEEVGLRSASSN.LWFRVP...FAR.DDAWQHICLRlGRPG.SMYWDVKINDQHFQDLWE
 1019- 1172 (172.20/101.60)	LQKGSNSTPWGSGvRIANTSDA.....................dshiryDSEG.........VVL..SYYS..VNADSIKKLVADIQrlSNARTFARGMrklLGARADEkfedSNANSE...N...KALAAIKGASDATD..RISEQMrKQFRI...EAVGLMS.....LWFSFGsgvLARfVVEWES.....GKEGcTMHVS...PDQ....LWP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     266.14|      81|    1166|     543|     627|       2
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  543-  627 (124.95/89.82)	LLMGFPECGSSYFLLMELDKDFKPVFKLLESQSDTPEKAQSLVDLsNVVRVKTVDIGRMQICEDELNLSLlnsKKLLSILPSDGG
 1711- 1791 (141.19/89.77)	LRYAFGENPNVLFLGMEGSHGGRACWLRVDDWERCKQRVARTVEV.NGNSAGDVNQGRLRVVADSVQRTL...HAYLQGLRDGGG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     465.92|     146|     162|    1185|    1346|       3
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 1185- 1346 (231.62/156.81)	EVASLLDCIRLT.AGPLHALAAATRPARAAPvSGVPGVTAPMSSVAKQTSYVPslPSNVSTRINQPASG.PGVNPVSVTVGALGTHHPsaamlaaaaaaAGRGGPGIVPSSLLPIDVSVVLRGPY...WIRIIYRKKFAVDMRCFAGdQVWLqPATPPKGGPEVGGS
 1359- 1509 (234.30/128.04)	HVAQELNGIDSNfTGSQQAVGLTNSNSLNAG.SQLPAANTNRTNLSNSTGLVR..PANAVTGFNRTANGlPSASNLAVVNAGMPLRRP...........PGTGVPAHVRGELNTAIIGLGDDGGYgggWVPLVALKKVLRGILKYLG.VLWL.FAQLPDLLKEILGS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.57|      12|    1161|     381|     392|       4
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  381-  392 (23.35/16.42)	KLLLRVICCNRY
 1545- 1556 (20.22/13.16)	QLLLQVISVKRF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.88|      38|     208|     209|     249|       5
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  209-  249 (59.05/47.69)	HME.LLVGERSGPMKLDDfrRHALGDDLeRRMAAADNPFMTL
  420-  458 (61.83/38.53)	HVEdMLADSRKKDNKFDS..REYQGQEV.LRVRAFGSSFFTL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12561 with Med14 domain of Kingdom Viridiplantae
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