<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12557

Description mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHGGSCTSAVNNSTIGGSSARDSSRVESASLPPNFSRRPLQLTPYKLKCDKEHLNSRLGPPDFLPQTPNCPEETLTKEYVQSGYRETVEGLEEAREISLSQVQAFTKPVIFKCKEAIRKCHRAINESRAQKRKAGQIYGVPLEGLQLTKPGTFPDQRACGEEFRKKWIEGLSQQHKRLRSLADHVPHGYRRKSLFEVLIRNNVPLLRATWFVKVTYLNQVRPGSSSMSSGVPDKTHISRSEQWTKDVIDYLQYLLDEFISRNSVHSALHIRDRSPQMGYAGSIQLKSDPTLGTIDCEEPSLHFKWWYVVRILQWHQREGLLIPSLIIDWVLNQLQEKELLGVLQLLLPVIYGFIDTVVLSQSYVRTLVGIAIRFIQEPSPGGSDLVDNSRRAYTMAALAEMLRYLMLAVPDTFVALDCFPMPPCVMTNVVTDGSLYSKVTEDARKVKNGPFEVAYFLRDKGPEVRSDSYSISRVVSSIQKRAQNLAMAARPGHPGQNVAKALHALDKALAHGDLREAYKFLLENVHDSSIDDCWFAEVSSCLRSSLKYIRSVTLSSICSVFFICEWATCDFRDFRYAPPRGIKFTGRKDFSAIYIAVRLLKLKMREAGLSSRLREHKIVKNDYLRTDPGQLTNYSGRSPGSGASEPLCYKRCASGKCGDFLGMFDSPSPLHDILVCWIDQHEVQNTEGFKRLQLLIIELIRAGIFYPQAYVRQLIVSGLMDGNGPISDPTKQKRHCKILKHLPGQYVQDALEEARIAESHVLSEVMNVYCNERKLVLHGKIDPYSTTCGSSYHKHKPRPNSGESLSAPSIDQLRSSESGSFQLSKVVGRGAELEELKGSITTLLQLPSSSSTDTGVDETQVSFKKAVVSGSNGMDNSEGTPGCEECRRAKKQKISEEKSSYSQIYPLNPSDDEETWWMRKGQKSIESFRAEPPPKPAKSASKGRQKVVRKTQSLAQLAAARIEGSQGASTSHVCDSKISCPHHRSGIEGIAPKSADGTRMPNGDVVSIGKVLKGLRFMEKRTITVWLVGIVKQLVEESEKTVTKVGQYGRPFSAADERGFVRWKLGEDELSAVLYLIDSCDEFVLAAMFLLWLLPKVLGSCSATVHGSRNILTIPKNAENNVCEVGEAYLLSSMRRYESIIVAADLIPETLSVVMRRAQAILTSNGRVSGSPTVIYARYLLKKYGSVGSVTEWEKTVKSTFDKRLASEVESGRLLDGEFGYPLGVPVGVQDPDDYFRQKITGVRVSRVGLSMRDIVQKKVDEAVNYFYGKDRKLFGPNSGKIPGFQKWEDVYQIGQQIVMGLMDCMRQTGGAAQEGDPTLVSSAISAIVCNIGQVIAKIPDLTASNNHLSFSSTSASLHFARCILRIHVICLCILKEALGERQSRVFEVALATETSSALAPVFAPGKAPRSQFQLSPELNDSNPSSDILNNSSRVALGRAAKISAAVSALVIGAILQGVASLERMVSLFRLKDGLDVVHFMRSMRSNSNGNARSVGTLKADSLAEVSVHWFRVLVGNCRTVSDGFIVDLLGEASILALCRMQRMLPLNLVFPPAFSMFAFVLWRPLILNASSGTRDEVQQLHHSLLLAFGDVIKHLPFREVCLRDTHSLYDLIAADTVDSDFASLLEASGVDLRTKTSAFVPLRARLFLNALIDCRIPQPIVKQDDGNQVGVQGESKFHGAENETKLLDKLVYILDTLQPAKFHWQWIELRLLLNEQAVIEKLEGHDLSLVEALRSLSPNTDKASVSENESNIIEMILTRLLVRPDAAPLFSEVVHLLGRSLEDSMLLQAKWFLGGHDVLFGRKSVRQRLINIAVSKGLSTRAQYWKPWGWCPSNSDPTTSKGEKFKSEVSSIEEGEVVDEGTTLKRPVKGSGHTVDVEGFLVRQQHVTERALVDLILPCLDQASDDSRSTFASDMIKQMNHIEQQINAVTREASKPAGTIASGIESPTTKSSRKGTRGSSPGLARRASGPAETVPPSPVALRASLSLRLQFILRLFPIIYADREPSGRNMRYMLASVILRTLGSRIVHEDASHFFNQAYSSKRELDSLVEASSTASVVMSLESLFDRLLLLLHGLLSSHQPRWLKGKSSSKSSSESSKDYSAFEREGAENLQNELDRMQLPETVRWRIQSAMPILFPSVRWSISCQPPSVAPAALSSLLPSNPISVLHSSNGLNQTQRTPVSLLRTAMSVSGKAKHVSSQQENDLEVDPWILLEDGAGSSQSSSNSTLVGGSDNANLKASNWLKGTVRVRRTDLTYIGAVDDDS
Length2268
PositionKinase
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.242
Instability index46.82
Isoelectric point8.87
Molecular weight251093.08
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12557
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     372.32|     121|     610|     709|     883|       1
---------------------------------------------------------------------------
  177-  307 (194.71/89.19)	QHKRLRSLADHVPHGYRRKSLFEVLIRNNVPL..LRATWFV..KVTYLNQVRPGSSSMSSGVpdKTHISR...SEQWTKDVIDYLQylldefiSRNSVHSAL.HIRDRSPQM.GYAGSI....QLKSDPTLGTiDCEEPSLHFK
  734-  867 (177.61/156.66)	KQKRHCKILKHLPGQYVQDALEEARIAESHVLseVMNVYCNerKLVLHGKIDPYSTTCGSSY..HKHKPRpnsGESLSAPSIDQLR.......SSESGSFQLsKVVGRGAELeELKGSIttllQLPSSSSTDT.GVDETQVSFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.70|      20|     610|     709|     733|       2
---------------------------------------------------------------------------
  714-  733 (38.42/29.43)	VRQLIVSGLMD......GNGPISDPT
 1297- 1322 (32.28/12.20)	IGQQIVMGLMDcmrqtgGAAQEGDPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.82|      12|     610|     872|     883|       3
---------------------------------------------------------------------------
  872-  883 (23.48/15.12)	SGSNGMDNSEGT
 1489- 1500 (22.34/13.99)	SNSNGNARSVGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     301.57|      98|     411|    1647|    1749|       4
---------------------------------------------------------------------------
 1647- 1749 (143.43/114.39)	RARLFLNALIDCRIPQpIVKQDDGNQVGVQGESKFHGAENETKllDKLVYILDTLQ.PAKFHWQwIELRLLLNEQAVIEKLEGHDLSLV.EALRSLSPnTDKASV
 2071- 2170 (158.14/103.94)	RLLLLLHGLLSSHQPR.WLKGKSSSKSSSESSKDYSAFEREGA..ENLQNELDRMQlPETVRWR.IQSAMPILFPSVRWSISCQPPSVApAALSSLLP.SNPISV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.38|      35|     553|      37|      71|       5
---------------------------------------------------------------------------
   37-   71 (66.05/36.41)	NFSRRPLQLTPYKLKCDKEHLNSRLGP.....PDFLPQTP
  592-  631 (53.33/28.04)	DFSAIYIAVRLLKLKMREAGLSSRLREhkivkNDYLRTDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.51|      15|     250|    1103|    1117|       6
---------------------------------------------------------------------------
 1103- 1117 (27.88/14.34)	SCSATVHGSRNILTI
 1356- 1370 (27.63/14.16)	STSASLHFARCILRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.34|      41|    1585|     357|     404|       8
---------------------------------------------------------------------------
  357-  404 (60.15/61.03)	IDTVVLSQSYV..RTLVGIAIRFIQEPSpggsdlvDNSRRAYTMAALAEM
 1881- 1923 (64.19/46.63)	VEGFLVRQQHVteRALVDLILPCLDQAS.......DDSRSTFASDMIKQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12557 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKSSYSQIYPLNPSDDEETWWMRKGQKSIESFRAEPPPKPAKSASKGRQKVVRK
2) GSITTLLQLPSSSSTDTGVDETQVSFKKAVVSGSNGMDNSEGTPGCEECRRAKKQ
3) IEQQINAVTREASKPAGTIASGIESPTTKSSRKGTRGSSPGLARRASGPAETVP
4) SCTSAVNNSTIGGSSARDSSRVESASLPPNF
900
841
1926
8
953
895
1979
38










Molecular Recognition Features






MoRF SequenceStartStop




NANANA