<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12553

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPATGAAGIGMPPRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQALQAQTPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQTLPGQMLYAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAVPSSSIPLGRQPMAQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRKLEEDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length754
PositionTail
OrganismTarsius syrichta (Philippine tarsier)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Tarsiiformes> Tarsiidae> Carlito.
Aromaticity0.03
Grand average of hydropathy-0.684
Instability index85.70
Isoelectric point9.71
Molecular weight82759.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12553
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.53|      18|      19|     172|     189|       1
---------------------------------------------------------------------------
  163-  181 (32.81/ 6.34)	QQQQQQ.QqqFQQQQAALQQ
  248-  265 (33.01/ 6.44)	QQQQQQQQ..ALQAQTPIQQ
  290-  306 (32.72/ 6.30)	QHHQPPPQ..PQQPPVA.QN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.94|      28|      47|     270|     316|       4
---------------------------------------------------------------------------
  270-  316 (42.28/12.58)	QpqPPPSQALPQQLQQMHHPqhhqpppqpqqppvaqnQPSQLPPQSQ
  407-  434 (36.67/ 6.19)	S..AVPSSSIPLGRQPMAQV.................GQSSLPMLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.93|      20|      34|      82|     105|       6
---------------------------------------------------------------------------
   86-  105 (39.62/24.00)	QSLTGGPATGAAGIGMPPRG
  108-  124 (28.88/ 7.97)	QSLGGMGGLGTMGQPMP...
  126-  140 (26.43/ 9.03)	...SGQPPPGTS..GMAPHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.91|      21|      34|     470|     490|       8
---------------------------------------------------------------------------
  460-  480 (37.61/11.65)	PSSQPNSNVSSGPAPSPSSF.L
  481-  502 (34.29/ 9.95)	PSPSPQPSQSPVTARTPQNFsV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.62|      29|      35|     532|     562|      10
---------------------------------------------------------------------------
  532-  562 (40.72/32.88)	LDKLKQLSKYIePLRRMiNKID.KNEDRKKDL
  569-  598 (46.90/28.48)	LDILTDPSKRC.PLKTL.QKCEiALEKLKNDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     187.85|      45|      46|     645|     690|      11
---------------------------------------------------------------------------
  599-  643 (63.12/30.01)	..AVP....TPP.PPPVPPTKQQYLCQPL.LDAVLANIRSPVfnHSLYRTFVP
  645-  690 (70.25/37.90)	MTAIH....GPPiTAPVVCTRKRKLEEDE.RQSIPSVLQGEV..ARLDPKFLV
  692-  735 (54.48/24.82)	LDPSHcsnnG...TVHLIC....KLDANPfLQSVHRCMTSRL..LQLPDKHSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12553 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPATGAAGIGMPPRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAT
2) QALQAQTPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQTLP
3) QPQVQPQVQQVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAVPSSSIPLGRQPMAQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
70
255
349
148
328
537










Molecular Recognition Features






MoRF SequenceStartStop




NANANA