<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12552

Description mediator of RNA polymerase II transcription subunit 23 isoform X1
SequenceMVQMETQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAKEVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSIQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYELHLRDRAPLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPVCDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPTAGPPQAMSSGSPAPQSNQVPVSLPVTQ
Length1377
PositionTail
OrganismTarsius syrichta (Philippine tarsier)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Tarsiiformes> Tarsiidae> Carlito.
Aromaticity0.10
Grand average of hydropathy-0.001
Instability index45.85
Isoelectric point7.09
Molecular weight157206.08
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12552
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.73|      28|      43|     610|     638|       2
---------------------------------------------------------------------------
  610-  638 (48.25/33.17)	LHTLLEMFSYRM......HHIQPHYrVQLLSHLHT
  650-  683 (42.48/24.26)	LHLCVESTALRLitalgsSEVQPQF.TRFLSDPKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.70|      26|      89|    1074|    1101|       3
---------------------------------------------------------------------------
 1074- 1101 (47.40/34.14)	DTYYCRLIGRLVDTMAgkSPGPFPNCDW
 1167- 1192 (47.29/27.73)	EPYWIVLHDRIVSVIS..SPSLTSETEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.83|      52|     619|     705|     759|       4
---------------------------------------------------------------------------
  705-  759 (89.75/69.81)	HVTDFFTG...SDSIQGTWC..KDILQTIMSFTPHnwASHtLSCFPGPLQAFFKQNNVPQ
 1309- 1365 (85.08/54.30)	HMKYMFTGdsvKEQVEKIICnlKPALKLRLRFITH..ISK.MEPTAGPPQAMSSGSPAPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     201.51|      48|      49|     203|     251|       8
---------------------------------------------------------------------------
  179-  223 (58.36/39.20)	....C.LLPAY...FAVTEIRKLYP.....EG.klphwLLGNLVSDFVDTFRP.TARINS
  224-  275 (73.59/56.69)	ICGRCsLLPVVNNSGAICNSWKLDP.....ATL..rfpLKGLLPYD.KDLFEPqTALLRY
  276-  297 (23.51/10.52)	VLEQ....PY..SRDMVCNMLGLNK.....QTL...........................
  968- 1010 (46.05/29.07)	VCLR..FLPVFD..IVIHRFLELLPvskslETL..ldhLGGL..YKFHD..RP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.13|      32|     717|      51|      92|       9
---------------------------------------------------------------------------
   51-   92 (49.80/46.44)	WGGLSQESHeqciqwIVKFIHGQHSPKrisfLYDCL..AMAVET
  776-  809 (56.34/29.27)	WKSMSNEND......IITHFSIQGSPP....LFLCLlwKMLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.12|      33|     261|     571|     603|      12
---------------------------------------------------------------------------
  571-  603 (56.34/42.45)	ALVETYSRLLVYMEIESLG...IKG..........FISQLL...PTVFK
  830-  865 (50.61/37.28)	AHVRTFADFLVYEFSTSAGgqqLNK..........CIEILN...DMVWK
  872-  906 (17.17/ 7.06)	......DRLILCLAMRS........hegneaqvcyFIIQLLllkPNDFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12552 with Med23 domain of Kingdom Metazoa
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