<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12551

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPATGAAGIGMPPRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQALQAQTPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQTLPGQMLYAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQQQTAVQTAQAAQMVAPGVQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRKLEEDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWINRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length747
PositionTail
OrganismTarsius syrichta (Philippine tarsier)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Tarsiiformes> Tarsiidae> Carlito.
Aromaticity0.03
Grand average of hydropathy-0.727
Instability index86.84
Isoelectric point9.42
Molecular weight82435.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12551
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.28|      18|      19|     293|     311|       2
---------------------------------------------------------------------------
  265-  282 (35.51/ 6.32)	QPPMQQPQPPPSQALPQQ
  293-  310 (41.77/ 6.92)	QPPPQPQQPPVAQNQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.27|      33|      34|     404|     436|       4
---------------------------------------------------------------------------
  396-  428 (59.93/14.23)	SPGQQVQTPQSMP.PPPQPSPQPGQPSSQPNSNV
  429-  462 (46.34/ 9.11)	SSGPAPSPSSFLPsPSPQPSQSPVTARTPQNFSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.35|      21|      82|     150|     171|       6
---------------------------------------------------------------------------
  150-  170 (41.87/ 9.87)	QTQLQ.LQQVALQQQQQQQQQQ
  234-  255 (34.48/ 9.24)	QQQLQrMAQLQLQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.85|      12|     117|     196|     207|       7
---------------------------------------------------------------------------
  196-  207 (22.75/ 6.25)	QQQFQAVVQQQQ
  349-  360 (23.11/ 6.48)	QPQVQPQVQQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.78|      17|      27|     102|     118|       8
---------------------------------------------------------------------------
   81-   96 (22.16/ 8.66)	.PMNALQSLTGGPATGA
  102-  118 (33.45/17.08)	PPRGPGQSLGGMGGLGT
  130-  146 (30.17/14.64)	PPGTSGMAPHGMAVVST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.30|      16|      39|     492|     508|       9
---------------------------------------------------------------------------
  492-  508 (23.61/16.31)	LDKLKQLSKYIePLRRM
  529-  544 (28.69/15.60)	LDILTDPSKRC.PLKTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.46|      39|     130|     557|     596|      11
---------------------------------------------------------------------------
  558-  596 (74.71/37.77)	MAVPT..PPPPPVPPTKQ.QYLCQPLLDAVLANIRSPVF....NHS
  682-  727 (56.75/23.25)	LSVPAdyPAQSPLWINRQwQYDANPFLQSVHRCMTSRLLqlpdKHS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12551 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMVVQQPQVQPQVQQVQPQVQQQTAVQTAQAAQMVAPGVQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) HNKKSQASVSDPMNALQSLTGGPATGAAGIGMPPRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAT
3) QALQAQTPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQTLPG
343
70
255
497
148
329










Molecular Recognition Features






MoRF SequenceStartStop




NANANA