<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12546

Description mediator of RNA polymerase II transcription subunit 23 isoform X2
SequenceMVQMETQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAKEVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSIQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYELHLRDRAPLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPVCDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPTAGPPQAMSSGSPAPQSNQVPVSLPVTQ
Length1371
PositionTail
OrganismTarsius syrichta (Philippine tarsier)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Tarsiiformes> Tarsiidae> Carlito.
Aromaticity0.10
Grand average of hydropathy-0.003
Instability index45.69
Isoelectric point7.09
Molecular weight156565.35
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12546
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     455.75|     107|     260|     521|     627|       1
---------------------------------------------------------------------------
  521-  627 (175.06/112.78)	GSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLG...IKGFISQLLPTV..FKSHAWGILHTL......LEMFSYRMHHIQP.HYRVQLL
  651-  759 (137.39/86.81)	TALRLITA..LGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQ....GTWCKDILQTImsFTPHNWAS.HTLscfpgpLQAF.FKQNNVPQ.ESRFNL.
  787-  892 (143.31/90.89)	GS.PPLFLCLLWKMLLETDH..INQIGYRVLERIGARALV....AHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMV..WKYNIVT.LDRL...ilcLAMRSHEGNEAQVcYFIIQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     236.39|      74|     711|     191|     316|       2
---------------------------------------------------------------------------
  191-  267 (123.67/130.13)	RKLYPEGKLPHWLLGNLVSDFVdtFRPTARINSICGRC.SLLPVVNNSGAICNS....WKL....DPATLRFPLKGLLPYDKdLFE
  321-  403 (112.72/46.37)	EEKFDDGGTSQLLWQHLSSQLI..FFVLFQFASFPHMVlSLHQKLAGRGLIKGRdhlmWVLlqfiSGSIQKNALADFLPVMK.LFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.70|      26|      89|    1068|    1095|       3
---------------------------------------------------------------------------
 1068- 1095 (47.40/41.04)	DTYYCRLIGRLVDTMAgkSPGPFPNCDW
 1161- 1186 (47.29/33.35)	EPYWIVLHDRIVSVIS..SPSLTSETEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.84|      37|     711|     280|     316|       5
---------------------------------------------------------------------------
  280-  316 (65.99/44.26)	PYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAME
 1024- 1060 (65.85/44.15)	PLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNARE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.49|      46|     262|     974|    1019|       9
---------------------------------------------------------------------------
  974- 1019 (82.96/44.21)	IHRFLE..LLPVSKSLETLL..DHLGGLY..KFHDRPVTYLYN.TLHYYELHL
 1230- 1282 (64.52/32.93)	IPKFLTevLLPIVKTEFQLLyvYHLVGPFlqRFQQERTRCMIEiGVAFYDMLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12546 with Med23 domain of Kingdom Metazoa
Unable to open file!