<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12545

Description probable mediator of RNA polymerase II transcription subunit 26b isoform X1
SequenceMAKNTGTLNKWRDYFETANSDIFNVIEYAVMVAAVDYPKEFKLRRDRIAELLFTCKVIRCFGCDKVELAIPNAANDDDKVFVSEFGGCDVKESKSSRGDDQIGMNVNQKISNYSYDEAEALTDEIEQDSKTVGEVLRIKEIIDNFHDESDSDIYECLRRLQLMALSVETLKATEIGKSVNALRKHSSNNIRHLARTLVEDWKVMVEAWVNATTAFTENTPESMKASVVDEEEEGLPSPPLDDLAFISTQTTSMEFSQFFDGMDDDGNIQNTGEFNKNHENGRKDNPVRKQQFAESVTAAPKDRKVEKPKKQTSVVTPNKPFGGDSGPGRPIKPTFERKINNDEMKLLQKYDKGTIRPRHVPIQQNRLKCPDEDPDRVKLEATKRKLQERYQEAEKAKKQRTVQVMELNEIPKQGLRKQGPGHKNSHVRPGNHNRHWANGHR
Length441
PositionUnknown
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.889
Instability index41.62
Isoelectric point6.27
Molecular weight50272.85
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12545
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.10|      18|      19|     295|     312|       1
---------------------------------------------------------------------------
  283-  300 (28.81/14.75)	KDNPVRKQQFAESVTAAP
  301-  318 (30.29/15.82)	KDRKVEKPKKQTSVVTPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.35|      18|      19|     240|     257|       2
---------------------------------------------------------------------------
  214-  226 (14.70/ 6.57)	.........AFTENTPESMKAS
  239-  256 (32.43/23.17)	P....LDDLAFISTQTTSMEFS
  257-  275 (21.22/12.68)	QffdgMDDDGNI..QNTG.EFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.23|      16|      22|      62|      80|       3
---------------------------------------------------------------------------
   62-   80 (24.28/25.51)	GCDKVElaiPNAANDDDKV
   87-  102 (28.95/20.51)	GCDVKE...SKSSRGDDQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.27|      13|      21|     126|     139|       5
---------------------------------------------------------------------------
  126-  139 (17.62/17.47)	EQDSkTVGEVL.RIK
  148-  161 (19.65/13.33)	ESDS.DIYECLrRLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.58|      14|      28|     167|     181|       7
---------------------------------------------------------------------------
  167-  181 (17.94/13.66)	VETLKATeIGKSVNA
  198-  211 (26.64/15.81)	VEDWKVM.VEAWVNA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12545 with Med26 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SQFFDGMDDDGNIQNTGEFNKNHENGRKDNPVRKQQFAESVTAAPKDRKVEKPKKQTSVVTPNKPFGGDSGPGRPIKPTFERKINNDEMKLLQKYDKGTIRPRHVPIQQNRLKCPDEDPDRVKLEATKRKLQERYQEAEKAKKQRTVQVMELNEIPKQGLRKQGPGHKNSHVRPGNHNRHWANGHR
256
441










Molecular Recognition Features






MoRF SequenceStartStop




1) EFSQF
2) GHKNSHVRPGNHNRHWANGHR
3) GRPIKPTFERKINNDEMKLLQKY
4) KQGLRK
254
421
328
412
258
441
350
417