<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12540

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPATGAAGIGMPPRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQALQAQTPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQTLPGQMLYAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAVPSSSIPLGRQPMAQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRKLEEDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWINRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length761
PositionTail
OrganismTarsius syrichta (Philippine tarsier)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Tarsiiformes> Tarsiidae> Carlito.
Aromaticity0.03
Grand average of hydropathy-0.685
Instability index86.59
Isoelectric point9.63
Molecular weight83630.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12540
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      18|      19|     267|     285|       2
---------------------------------------------------------------------------
  239-  256 (33.48/ 6.28)	QPPMQQPQPPPSQALPQQ
  267-  284 (40.58/ 7.39)	QPPPQPQQPPVAQNQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     213.46|      33|      34|     399|     431|       3
---------------------------------------------------------------------------
  288-  316 (35.12/ 6.84)	QSQTQPLV.SQAQTL....PGQMLYAQQQLK.FVR
  317-  342 (34.52/ 6.58)	APMV.VQQ....PQV.QPQV.QQVQ.PQVQQ.QTA
  393-  425 (64.45/19.50)	QPMAQVGQ.SSLPMLSSPSPGQQVQTPQSMP.PPP
  426-  455 (44.83/11.03)	QPSPQPGQpSSQPN.SNVSSGPA.PSPSSF...LP
  456-  479 (34.54/ 6.59)	SPSPQPSQ..........SPVTA.RTPQNFSvPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.57|      17|      19|      60|      76|       6
---------------------------------------------------------------------------
   60-   76 (32.80/16.26)	QSLTGGPATGAAGI...GMP
   82-   96 (28.69/13.22)	QSL..GGMGGLGTM...GQP
   97-  115 (23.08/ 9.06)	MPLSGQPPPGTSGMaphGM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.70|      14|     117|     540|     553|      10
---------------------------------------------------------------------------
  506-  519 (22.52/15.45)	LDKLKQLSKYI....EPL
  526-  542 (14.75/ 7.52)	IDKNEDRKKD.lskmKSL
  543-  558 (19.44/12.31)	LDILTDPSKRC..plKTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.60|      38|     124|     561|     598|      11
---------------------------------------------------------------------------
  561-  598 (70.33/30.18)	CEIALEKLKNDM.........AVPT..PP.PPPVPPTKQ.QYLCQPLLDAV
  600-  639 (31.74/ 9.55)	ANIRSPVFNHSLyrtfvpamtAIHG..PPiTAPVVCTRK.RKL........
  695-  725 (32.53/ 9.97)	..........EL.........SVPAdyPA.QSPLWINRQwQYDANPFLQSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12540 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPATGAAGIGMPPRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAT
2) QALQAQTPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQTLP
3) QPQVQPQVQQVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAVPSSSIPLGRQPMAQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
44
229
323
122
302
511










Molecular Recognition Features






MoRF SequenceStartStop




NANANA