<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12530

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQPTDPNLEWTQISTRYLREQLAKISEFYHMTSSTGDGPVPVPPEVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADDRDSKDHDVKMEEQSIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNGEKLVKSEKTRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGISLFNPNGIGSADTSSTRPNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLIEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDDYSQSNIYRVPPNYTPISSQMMHHPQSTLWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQSRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPSYNSRAYPAAHSNPALMERLRQIQQQPTGYVQQQASAYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPPQPQQPPQAQQSSQPQSQTLGIQAMQPQQPL
Length2138
PositionKinase
OrganismTarsius syrichta (Philippine tarsier)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Tarsiiformes> Tarsiidae> Carlito.
Aromaticity0.07
Grand average of hydropathy-0.419
Instability index56.79
Isoelectric point6.97
Molecular weight238893.35
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12530
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     214.61|      27|      27|    2081|    2107|       1
---------------------------------------------------------------------------
 1903- 1924 (24.43/ 7.24)	.Q.P........PSLHAITSQ....QQL.IQMKLLQQ.
 1962- 1993 (38.03/15.74)	PQYPglqqaqTMPQGYTMYGT....QMP.LQ.QTPQQQ
 2001- 2028 (30.97/11.33)	PSYN......SRA.YPAAHSNpalmERL.RQIQ..QQP
 2041- 2058 (23.76/ 6.82)	..QP......LT.......GS....QRL.NHQALQQSP
 2081- 2107 (54.65/26.12)	PQDP......MRPRQPQVRQQ....QRL.LQMQQPQQP
 2110- 2137 (42.77/18.70)	PQQP......PQAQQSSQPQS....QTLgIQAMQPQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     480.04|     158|     203|     909|    1109|       2
---------------------------------------------------------------------------
  909- 1107 (253.13/245.99)	SYTTGLCVCIVAVLRRyhsclilnpdqtaQVFeGLCGVVKHVVNPSECSSPerC..............ILAYLYDLYVSCsHLRSKFGDLF...SSACSKVKQTIYNNVMPANSNLRWDPDFMM..DF.IENPSARSI...NYSMLGkilsdnaanrysfvcntlmnvcmgHQDAGRINDIANFSSELTACCTVLSSEWLG.......VLKALCCS...SNHVWGFNDVLCT
 1114- 1304 (226.90/143.17)	SFHDSLATFIAILIAR.............QCF.SLEDVVQHVALPSLLAAA..CgdadaepgarmtcrLLLHLFRAPQAC.LLPQATGKPFpgiRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMlgDAkIGNNNVSSLkndDFTMRG........................LRRDGNADDIWTASQNSKSCGKSISIETANlreyaryVLRTICQQewvGEHCLKEPERLCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.51|      16|     203|    1674|    1698|       4
---------------------------------------------------------------------------
  664-  679 (30.54/13.49)	MG..IDSGTTNI..FDEVDK
 1676- 1695 (20.97/25.45)	MGslIDTKGNKIagFDSIDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.15|      30|     288|     554|     584|       6
---------------------------------------------------------------------------
  554-  584 (46.39/38.18)	ESISS.ASLAGSSLPVFQNVLLRFlDTQAPSL
  846-  876 (49.76/35.88)	EQITSfASGTSYHLPLAHHIQLIF.DLMEPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.14|      20|     288|    1534|    1563|       7
---------------------------------------------------------------------------
 1514- 1533 (32.77/31.64)	QDE..QREGLLTSLQNQVNQIL
 1542- 1563 (29.37/16.20)	QDDikARQMMHEALQLRLNLVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.82|      59|     156|    1446|    1510|       8
---------------------------------------------------------------------------
 1446- 1510 (91.54/77.45)	GVWLVAPLIARLPTSVQGrvlkaaGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSL.VLTC
 1609- 1668 (90.27/63.64)	GVLINGTLASDLSNASPG......GSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLpKQTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.47|      12|     286|     408|     419|       9
---------------------------------------------------------------------------
  408-  419 (25.34/14.25)	PMPG.....GNTAFNQQ
  695-  711 (18.13/ 7.99)	PMPGescenANTSLGRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.07|      15|      16|    1927|    1941|      15
---------------------------------------------------------------------------
 1927- 1941 (28.20/15.18)	QQRLLRQAQSRPFQQ
 1946- 1960 (26.86/14.07)	DQAALFAAQARPSPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12530 with Med12 domain of Kingdom Metazoa
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