<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12529

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTSSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPIDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITLQHPGRVPIILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVGGKALGSADLMEHHSGSQSPLVTTGELGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQCGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFASSGSSMSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSANSSHPMSSKHNVSGGEFQSKREKSDKDKSKVSASGSSVDSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKERDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1579
PositionMiddle
OrganismTarsius syrichta (Philippine tarsier)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Tarsiiformes> Tarsiidae> Carlito.
Aromaticity0.04
Grand average of hydropathy-0.677
Instability index53.71
Isoelectric point8.87
Molecular weight168267.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
chromatin binding	GO:0003682	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12529
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.86|      20|      21|    1088|    1108|       1
---------------------------------------------------------------------------
 1084- 1103 (36.16/10.19)	TSSGSVSSSGS.KSHHSHSSS
 1105- 1125 (24.70/ 6.70)	SSSSSASTSGKmKSSKSEGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     503.16|      65|      65|    1357|    1421|       2
---------------------------------------------------------------------------
  930- 1017 (50.13/13.04)	DFSIISVGGKA...LGSadlmehHSGS.QSPLVttGELGKEKT..QKrvK..EGNG........TS...N.........STLS......GPG.LDSKPGK...........RS...............rtpsndgkskdkppkrkkADT
 1018- 1079 (65.77/20.17)	EGKSPSHSSSNrpfTPP......TSTG.GSKSP..GSSGRSQ...TP..P..GVAT........PPI.PK.........ITIQ......IPK.GTVMVG............KP................................sS..
 1134- 1205 (67.57/20.99)	....YSSQGSS...GSS......QSKN.SSQCG..GKPGSSPI..TK..HglSSGS........SSTKMKpqgkpsslmNPLS......KPN.ISPSHS............RP..............................pggSDK
 1206- 1265 (60.98/17.99)	LASPM....KP...VPG......TPPS.SK..........AKSPISS..G..SGGShmsgtsssSGMKSS.........SGLG......SSG..SLSQKT...........PP.................................SSN
 1266- 1359 (43.74/10.13)	S...CTASSSS...FAS......SGSSmSSQN....QHGSSK...........GKS........PSRNKK.........PSLTavidklKHGvVTSGPGG...........EDpmdgqmgvsansshpmsskhnvsggefqskrekSDK
 1360- 1427 (98.24/34.98)	DKSKVSASGSS...VDS......KKTS.ESKNV..GSTGVAKIIISK..H..DGGS........PSIKAK.........VTLQ......KPG.ESSGEGL...........RP..............................qmaSSK
 1428- 1500 (75.05/24.40)	NYGSPLISGST...PKH......ERGS.PSHSK..SPAYTPQNLDSE..S..ESGS.........SIAEK.........SYQN......SP...SSDDGI...........RP......................lpeystekhkkHKK
 1501- 1555 (41.68/ 9.18)	EKKKVKDKDRD...RDR......DKER.DKKK....S...........................HSIKPE..........SWS......KSP.ISSDQSLsmtsntilsadRP....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     384.82|      64|      64|     549|     612|       3
---------------------------------------------------------------------------
  549-  600 (89.02/32.47)	................GM..T..TGNNPM.....SGTTT...PTN.TFP...GGPI......TTLFNM.SMS.IKDRHESVGHGED..F.S.KV.SQ
  601-  662 (72.23/24.97)	NPILTSLLQITG..ngGS..T..IGSSP.........TP...PHH.TPP.....PVssmagnTKNHPM.LMNlLKD.....NPAQD..F.S.TL.YG
  663-  720 (55.89/17.67)	SSPLERQNSSSGsprmEM..C..SGSNKT.....KKKKSsrlP.....P...DKP...................KHQTEDDFQREL..F.SmDVdSQ
  721-  781 (53.86/16.76)	NPIFD..........vNM..TadTLDTPHitpapSQCST...PPT.TYPqpvPHPQ......PSIQRMvRLS.SSD...SI..GPD..V.T.D....
  782-  827 (43.27/12.03)	..ILSDIAEEAS....KLpsT..SDDCP..........................PI......GTPVRD.S........SSSGHSQStlFdS.DV.FQ
  833-  888 (70.55/24.22)	NPYTDPADLIA...........dAAGSPS.....S..DS...PTNhFFP...DG.........VDFNP.DL..LNSQSQS.GFGEE.yF.D.ES.SQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.31|      12|      22|     890|     902|       4
---------------------------------------------------------------------------
  890-  902 (20.18/16.48)	GDNDD..FKGfASQA
  913-  926 (20.13/10.38)	GDNGEtkFKG.NSQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     209.57|      48|      48|     152|     199|       5
---------------------------------------------------------------------------
  152-  182 (39.58/18.65)	.........................KHL..KGLV.NLYNL..........P..GDNKLKTK.MYLALQSLEQ
  183-  233 (68.01/37.51)	DLSKMAIMYWKATNAGP......ldKIL..HGSV.G.YLT..........PrsGGHLMNLK.YYASPSDLLD
  234-  296 (53.10/27.62)	DKTSSPIILHE..NNVPrslgmnasVTI..EGTS.AMYKLpiaplimgshP..IDNKW.TP.SFSSITSANS
  298-  342 (48.88/24.82)	DLP..ACFFLKFPQPIP...........vsRAFVqKLQNC..........T..GIPLFETQpTYVPLYEL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.30|      18|      22|     447|     464|       6
---------------------------------------------------------------------------
  447-  464 (32.49/18.52)	ES.RFSVSFQHPVNDSLVC
  471-  489 (27.81/14.80)	DStHVSCKLYKGLSDALIC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12529 with Med1 domain of Kingdom Metazoa
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