<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12522
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MAASSSGEKEKERLGGGLGAAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQPGEENQVLELLIHRDGEFQELMKLALNQGKIHYEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSSDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD |
Length | 270 |
Position | Middle |
Organism | Tarsius syrichta (Philippine tarsier) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Tarsiiformes> Tarsiidae>
Carlito.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.628 |
Instability index | 50.79 |
Isoelectric point | 4.96 |
Molecular weight | 29709.00 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
GO - Biological Function | thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
transcription by RNA polymerase II GO:0006366 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP12522
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 110.49| 29| 29| 53| 81| 1
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28- 49 (27.29/16.57) .ERLLSALE...D...LEVL..SR..ELIEMLA
53- 81 (52.55/38.55) NQKLLQPGE...ENQVLELLI.HRDGEFQELMK
85- 112 (30.65/19.49) NQ.....GKihyEMQVLEKEVeKRDSDIQQLQK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 84.20| 23| 23| 216| 238| 2
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216- 238 (44.38/31.99) LAPQYPWQSNDMSVNMLPPNHSS
242- 264 (39.82/27.94) LEPPGHNKENEDDVEVMSTDSSS
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