<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12521

Description mediator of RNA polymerase II transcription subunit 25
SequenceMSSLSTLLRAKSRKTPPPPPHLRGWFGPYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGATLSAASQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQATPGVGPPFNQAPAPPLPSGPPGAPKPPPASQPSLVSHVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSATQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGGQQAPSGLGPILEDQARPAQNLLQLRPPQSQPQGTVGASGATGQSQPQGTAQPPPGAPQGPPGTAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length714
PositionUnknown
OrganismTarsius syrichta (Philippine tarsier)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Tarsiiformes> Tarsiidae> Carlito.
Aromaticity0.05
Grand average of hydropathy-0.294
Instability index60.54
Isoelectric point9.47
Molecular weight75001.49
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12521
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     717.85|     130|     286|     292|     421|       2
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   16-  140 (146.40/27.10)	PPPPPHLRG......W...FGPYGGTQYSLV......VFNT..VDC......AP...........E....S....YVQCHAP................T..SSAYEFVTWLdGIKFMGG.GGESCSLIAegLSTALQLFDDFK..KMREQIGQTHRV....CLLICNSPPYLlpavesTTYSgcTTESLVQK....................................
  142-  293 (106.82/17.96)	.....GERGihfsivS...PRKLPALR.LLF....EKAAP...PAM......LEPLQPPTdvsqdP....RhmvlVRGLVLP...............vG..GGSAPGPLQP.KQP...................VPLPPAAPSGATLSAASQ..QSLppvPPQYQV.PG.NL......SAAQ..VAAQNAVEAA.knqkaglgprfspitplqqatpgvgppfnqaPA
  294-  455 (216.57/43.31)	PPLPSGPPG......A...PKPPPASQPSLV....SHVAPG..PGL......APPAQPGA.....P....S....MAGTVAP................G..GVSGPSATQL.GAPALGGQQSVSNKLLA..WSGVLEWQEKPKPASVDANTKLTRSL...PCQVYVNHGENL......KTEQ..WPQKLIMQLIpqqllttlgplfrnsrmvqfhftnkdleslkgLY
  456-  574 (110.09/18.71)	RIMGNGFAG......CvhfPHTAPCEVRVLMllysSKKKIF..MGL......IPYDQSGF.....V....N....GIRQVITnhkqvqqqkleqqrgmG..GQQAPSG..L.G.PILEDQARPAQNLLQ.....LRPPQSQPQ.GTVGASGATGQSQ...P...................................................................
  582-  683 (137.98/25.16)	PGAPQGPPG.....tA...PGPPPPG.PILR....PQ.NPGanPQLrslllnPPPPQTGV.....PppqaS....LHHLQPP................GapALLPPPHQGL.GQPQLGPP......LL............HPPPA........................QSW......PT.Q..LPQRAP...L................................PG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12521 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGATLSAASQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQATPGVGPPFNQAPAPPLPSGPPGAPKPPPASQPSLVSHVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSATQLGAPALG
2) HKQVQQQKLEQQRGMGGQQAPSGLGPILEDQARPAQNLLQLRPPQSQPQGTVGASGATGQSQPQGTAQPPPGAPQGPPGTAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
200
512
358
712










Molecular Recognition Features






MoRF SequenceStartStop




NANANA