<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12517

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNSLMNVCMGHQDAGRINDIANLCAELTACCTMLSSEWLGVLKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVYLFSQATGKSFPGIRSSCDRHLLTAAHNSIEVGAVFAVLKAILMLGDAEIGSSSINSLKNEDFSMRGLLDDLDDDEIWGASHTLTSCGKAISIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRNTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGSEENKRAYMNLVKKLKKELGDKHSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHMHPKPKPRSYYLEPLLLPPEEEEEEPTTPVSQEPERKSAELSDQGKPNTDDEKKSKGRKRKTKSNSRADEYPQNNIYRVPPTYSPISSQMMHHPQSALWGYNIMGQPQQPGFFVQNQPLPPGGSRLDPAGSFVPTNTKQALSNMLQRRSGTMMQPPSIHAITSQQQLLQMKLLQQQQQQQQRLLRQQTQTRTFQQGQPIDQAAIFTQQVRPSSQLPQYPGLQQAQTMPHGYTMYSTQMPLQQQQPGGVVLSPSYNPRTYPATHSNPSLIERLRQMQQQPSGYIQQQAAAYLQPLTGTQRLTHQPLQQSSLVGGALENVPSTAPHPNLNSVQLPQEQMRQRQQQIRQQRLLQLQQQQQQGQQQALGLQAMPPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVNQYGHPSHF
Length1182
PositionKinase
OrganismAlligator sinensis (Chinese alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.06
Grand average of hydropathy-0.552
Instability index58.43
Isoelectric point8.18
Molecular weight132506.91
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12517
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     132.54|      24|      67|     858|     882|       1
---------------------------------------------------------------------------
  858-  881 (49.86/18.65)	QSALWGYNIMGQPQQPGFFVQNQP
  927-  945 (32.60/ 8.72)	QQQLLQMKLLQQQQQ.....QQQR
  947-  961 (15.80/ 6.96)	.........LRQQTQTRTFQQGQP
 1124- 1143 (34.27/ 9.68)	QQAL.GLQAM.PPQQPLF..PRQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.94|      30|      38|     268|     305|       2
---------------------------------------------------------------------------
  271-  300 (50.19/46.01)	SHTLTS....C.GKAISIETASLSEYARYVLRTIC
  307-  341 (41.75/16.43)	EHCLKEperlCtDKDLILDPVLSNKQAQKLLQLIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.66|      32|      36|     702|     737|       3
---------------------------------------------------------------------------
  702-  737 (45.16/54.15)	AGFDSI..DKKQgLQVSTKQKVSpwdLFEGHKNPAPLS
  739-  772 (55.50/44.48)	AWFGTVrvDRKV.IKYEEQQHLL...LYHMHPKPKPRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.37|      28|      31|    1033|    1063|       4
---------------------------------------------------------------------------
  999- 1021 (29.93/ 9.72)	T...QMplqQQQPG...GVV.......LSP..SYNPRT
 1033- 1063 (47.83/25.98)	ErlrQM...QQQPS...GYIQQQAAAYLQP.LTGTQRL
 1065- 1094 (24.61/ 6.65)	H...QP...LQQSSlvgGALENVPSTAPHPnLNSVQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.93|      27|      37|     346|     372|       5
---------------------------------------------------------------------------
  346-  372 (48.71/28.36)	IKEC.TEGDNPQRQHIKRILQNLDQWTL
  383-  410 (40.22/22.21)	IKQCmKEPGSGSVAEMNSLLDNIAKATI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.80|      26|      38|     433|     459|       6
---------------------------------------------------------------------------
  433-  458 (45.23/31.31)	PNSV.GNADTSNTRQNGKKTFLSSS...ER
  472-  501 (34.57/17.26)	PTSVqGRVLKAAGEELEKGQHLGSSskkER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.13|      16|      19|     798|     815|       7
---------------------------------------------------------------------------
  800-  815 (27.22/23.09)	KSAELSDQGKPNT.DDE
  817-  833 (20.91/ 7.82)	KSKGRKRKTKSNSrADE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.32|      23|      25|     581|     605|       8
---------------------------------------------------------------------------
  581-  605 (34.59/37.37)	DTVQRNTQWTTdwALLLLQIITSGT
  607-  629 (39.73/31.75)	DMQTNNELFTT..VLDMLGVLINGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.12|      16|     187|     965|     980|      13
---------------------------------------------------------------------------
  965-  980 (28.65/13.64)	AAIFTQ.QVRPSSQLPQ
 1154- 1170 (22.47/ 9.07)	AALVRQlQKQLSSNQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.50|      36|     276|     230|     265|      15
---------------------------------------------------------------------------
  230-  265 (58.84/38.03)	KAILMLGDAEIGSSSINSLKNEDFSMRGLLDDLDDD
  507-  542 (59.66/38.68)	KSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.85|      21|     494|     142|     184|      17
---------------------------------------------------------------------------
  160-  184 (30.06/52.50)	LLAAACGdpDAEPGARMTCRllLHL
  192-  212 (39.79/13.70)	LFSQATG..KSFPGIRSSCD..RHL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12517 with Med12 domain of Kingdom Metazoa
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