<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12499

Description LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 26
SequenceMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTSNEELAKRAKKLLRNWQKLIEPVTPNEPVPRGLPNPPGSANGGAHNCKPEAPPAAMPGSKPVNELKXXXXXRKRKGEHRDGHQGPPPPKVSKASHEVLQNSSPPPTNGIGGSPESFPSPVDVSLHTGPETSRTEHSENDKHSKIPVNAVKPHTSSPGLVKPSSTSSLLKTAVLQQHEKSEEIAGQHQPKSPRCSSFSPRSVRQDTFPRQHTTYSPKGSMPSPSQRSQLLDTAQVPSPPPSLMQPSTPPMPAKRLEVSQQSGPEVSHHWQEQVSSESQHRHPTGTLPQYTSPGCKTSSHPGESLTPHIGFSQDTSKMDSDDAASGSDSKKKKRYRPRDYTVNLDGQVTEGGVKPVRLKERKLTFDPMTGQIKPLTQKDPLQVEIPALAEQHRTETEEQEQKPNLQSPFEQTNWKELSRNEIIQSYLNRQSSLLSSSGVQTPGAHYFMSEYLKQEESTRKEARKTHVLAPHSKPTDLPGITREVTSDDLNRIREHHWPGVNGCFDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length572
PositionUnknown
OrganismAlligator sinensis (Chinese alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.04
Grand average of hydropathy-0.998
Instability index61.72
Isoelectric point8.76
Molecular weight62796.41
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12499
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     624.90|     132|     133|     140|     272|       1
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   10-  124 (137.90/58.75)	.....................SLEKYPITK....EALEETRLGKL.INDVRKKTSNEELAK..RAKKLLRNwQKLIEP.VTPNEPVPRGLPNP..PGSANGGAHNCKPEAPPAAMPGSKP......vnelkxxxxxRKRKGEHRDGHQGP....PP
  142-  275 (213.02/98.19)	PTNGiGGSPESFPSP...VDVSLHTGPETSR..TEHSENDKHSKIPVNAVKPHTSSPGLVKPSSTSSLLKT.AVLQQH.EKSEEIAGQHQPKS..PRCSSFSPRSVRQDTFPRQHTTYSPKGSMPS..........PSQRSQLLDTAQVP...sPP
  276-  390 (152.07/65.80)	PS...LMQPSTPPMPakrLEVSQQSGPEVSHhwQEQVSSESQHRHPTGTL.PQYTSPG.CKTSS........................HPGESltPHI.GFSQDTSKMDSDDAASGSDSKKKKRYR..........PRDYTVNLD.GQVTeggvKP
  402-  495 (121.90/51.21)	PMTG.QIKPLTQKDP...LQVEIPALAEQHR..TETEEQEQ.........KPNLQSP..FEQTNWKELSRN.EIIQSYlNRQSSLLSSSGVQT..PGAHYFMSEYLKQEESTRK..........................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12499 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LEETRLGKLINDVRKKTSNEELAKRAKKLLRNWQKLIEPVTPNEPVPRGLPNPPGSANGGAHNCKPEAPPAAMPGSKPVNELKXXXXXRKRKGEHRDGHQGPPPPKVSKASHEVLQNSSPPPTNGIGGSPESFPSPVDVSLHTGPETSRTEHSENDKHSKIPVNAVKPHTSSPGLVKPSSTSSLLKTAVLQQHEKSEEIAGQHQPKSPRCSSFSPRSVRQDTFPRQHTTYSPKGSMPSPSQRSQLLDTAQVPSPPPSLMQPSTPPMPAKRLEVSQQSGPEVSHHWQEQVSSESQHRHPTGTLPQYTSPGCKTSSHPGESLTPHIGFSQDTSKMDSDDAASGSDSKKKKRYRPRDYTVNLDGQVTEGGVKPVRLKERKLTFDPMTGQIKPLTQKDPLQVEIPALAEQHRTETEEQEQKPNLQSPFEQTNW
21
449










Molecular Recognition Features






MoRF SequenceStartStop




1) RVDALLLDLRQKFPPRFVQQ
2) VPMDQIKKEPEPAPEAIKTEEKETAKNTQQSAGTKGPPEKRMRLQ
176
202
195
246