<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12492

Description mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPASPQQMRDRLLQAIDSQSNIRNMVTVLEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLIEPVHQNEVALRALAGAAGSANGGAHNCRPEVGVASTPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPHKVPKASPDPLVPNASPLPTNGISGSPQSLPSPLDGSGHLGPDSSRLEPSDNEKHSTKIPVNAVRPRPSSPGLGKPPGPCLQTKAAHLDRADEPPGPPHPRGTSRCSFSPRNSRHEGSFARQRSSYIPKGPVASPSPRPQPLDTTQVPSPLPPAQPSTPPVRRMELLSSAESPVHWPEQPEGHPRLTGPACRVGLSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVTEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRVDSPVPTEQPPRTEQDQQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLKQEESSRRGARQPHVLLPLPTPTDLPGLTREITQDDLDRIQAQRWPGVNGCEDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length585
PositionUnknown
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.03
Grand average of hydropathy-0.913
Instability index66.03
Isoelectric point9.51
Molecular weight64257.42
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12492
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     364.40|      52|      78|     148|     199|       1
---------------------------------------------------------------------------
  113-  180 (74.03/23.80)	PEVGVASTPK.......SIHdlknrndiQR.........................LPGQrldrlgsrKR..RGDQRDLGHP...GPPH......KVP..KAS......PDPL............VPNASPL
  181-  238 (61.01/18.35)	PTNGISGSPQ.......SLP........SP.........................LDGS..ghlgpdSS..RLEPSD..NE...KHST......KIPvnAVR......PRPS............SPGLGKP
  239-  264 (33.04/ 6.65)	PGPCLQTKAA.......HLD...................................................RADE....PP...GPPH........P..RG..............................
  265-  313 (52.59/14.83)	.TSRCSFSPR.......N..........SR.........................HEGS.......fAR.....QRSSYIP...KGPV......ASP..SPR......PQPL........dttqVP..SPL
  314-  369 (61.86/18.71)	PPAQPSTPPV.......RRM........EL.........................LSSA........ESpvHWPEQPEGHPrltGPAC......RV...GLS......PDSS............KADSDAA
  370-  434 (47.43/12.67)	SSGGSDSKKK.......KRY........RP.........................RDYT.......vNL..DGQVTEAGVK...PVRL......KER..KLT......FDPMtrqikpltqkepVRVDSPV
  435-  523 (34.44/ 7.23)	PTEQPPRTEQdqqeakaSLQ........SPfeqtnwkelsrneiiqsylsrqsslLSSS.............GAQT....P...GAHHfmaeylKQE..ESSrrgarqPHVL............LPLPTPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12492 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LRALAGAAGSANGGAHNCRPEVGVASTPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPHKVPKASPDPLVPNASPLPTNGISGSPQSLPSPLDGSGHLGPDSSRLEPSDNEKHSTKIPVNAVRPRPSSPGLGKPPGPCLQTKAAHLDRADEPPGPPHPRGTSRCSFSPRNSRHEGSFARQRSSYIPKGPVASPSPRPQPLDTTQVPSPLPPAQPSTPPVRRMELLSSAESPVHWPEQPEGHPRLTGPACRVGLSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVTEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRVDSPVPTEQPPRTEQDQQEAKASLQSPFEQTNW
2) QSSLLSSSGAQTPGAHHFMAEYLKQEESSRRGARQPHVLLPLPTPTDLPGLTREITQDDLDR
94
478
462
539










Molecular Recognition Features






MoRF SequenceStartStop




1) RLKERKL
2) SKKKKRYRPRDYTVNLDGQV
404
376
410
395