<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12488

Description mediator of RNA polymerase II transcription subunit 25 isoform X8
SequenceMCRIPIYFVLDVVDKSLFDLKRPPDGFVVPILIVSWCGNRRDRDKTASSRMPRTNMAALASAEAARRPARASASRKRTSVGPGTATAAAALAGAARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRNHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLNGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPVDVSQDPRHMVLVRGLVLPVGGSSVPGPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQALPGLGPILEDQARPPQNLLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length838
PositionUnknown
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.05
Grand average of hydropathy-0.205
Instability index56.58
Isoelectric point9.28
Molecular weight88145.37
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12488
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.96|      29|      31|     415|     444|       4
---------------------------------------------------------------------------
  353-  383 (34.96/ 8.62)	PQQALPPVPPqyQVPGNLSAAQVAAQNAVEA
  416-  444 (60.05/18.14)	PAPPLAPGPP..GAPKPPPASQPSLVSTVAP
  670-  696 (39.95/ 8.22)	PQNLLQLRAP...QPQPQGAVGASVA.AGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.62|      23|      31|      49|      77|       5
---------------------------------------------------------------------------
   49-   71 (42.78/27.11)	SRMPRTNMAALASAEAAR.......RPARA
   79-  108 (34.84/11.49)	SVGPGTATAAAALAGAARgmvpgseGPARA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     194.75|      27|      31|     282|     308|       6
---------------------------------------------------------------------------
  282-  308 (46.72/15.05)	PR......KLPALRLLFEKAA................PPAMLEP.LQPPV
  314-  340 (43.26/13.30)	PR......HMVLVRGLVLPVG................GSSVPGP.LQPKQ
  457-  478 (34.09/ 8.67)	P.......SMAG...TVAPGG................VSG.PSP.AQLGA
  752-  792 (34.80/ 9.03)	PP......PQASLHHLQPPGApallppphqslgqpqlGPQLLHP...PPA
  796-  828 (35.89/ 9.58)	PTqlpqraPLPGQMLLSGGPR................GP.VPQPgLQPSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.74|      20|      24|     547|     568|       7
---------------------------------------------------------------------------
  547-  566 (35.86/13.64)	QQLLTTLGPLFR...N..SRMVQFH
  569-  593 (22.88/10.64)	NKDLESLKGLYRimgNgfAGCVHFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.57|      12|     265|     445|     456|       8
---------------------------------------------------------------------------
  445-  456 (23.55/ 7.50)	GTGLAPTAQPGT
  700-  711 (24.02/ 7.81)	GTTQAPTGAPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.13|      21|     111|     136|     166|       9
---------------------------------------------------------------------------
  109-  132 (31.48/23.60)	GGLVADVVFvieGTANLGPYFEEL
  146-  166 (39.65/13.43)	GGPPAETDF...GGDYGGTQYSLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.81|      16|      62|     651|     666|      11
---------------------------------------------------------------------------
  651-  666 (29.70/10.20)	GAQQALPGLGPILEDQ
  714-  729 (33.11/12.24)	GTAPGPPPSGPILRPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12488 with Med25 domain of Kingdom Metazoa
Unable to open file!