<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12486

Description mediator of RNA polymerase II transcription subunit 14 isoform X1
SequenceMAPVQLDNHQLIPPGGGGSSGSASAPAPQPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELLVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQEMKAILRNFNANENSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQTTLEDMEKCVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVSTADREDSPVMALLLQQFKDNIQDLISYTKTGKQTRTGTKHKLSDDPCPVECKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHNTINQSPSMIHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARLPGMSPANPSLHSPIPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1451
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.07
Grand average of hydropathy-0.177
Instability index51.42
Isoelectric point8.80
Molecular weight160561.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12486
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     208.38|      32|      32|    1033|    1064|       1
---------------------------------------------------------------------------
   13-   42 (37.65/16.57)	...................PPGGGGSSGSASAPAPQPPGAAVAAAAAAA
 1029- 1062 (50.92/25.74)	IN...............qsPSMIHTQSPGNLHAASSPSGALRAPSPASF
 1063- 1096 (45.65/22.10)	VP...............tpPPSSHGISIGPGASFASPHGTLDPSSPYTM
 1097- 1120 (40.43/18.49)	VS.................PS....GRAGNWPGSPQVSG....PSPAAR
 1151- 1199 (33.73/13.86)	MPtnmppprklpqrswaasIPTILTHSALNILLLPSPTPGLVPGLAGSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.03|      24|      29|    1323|    1348|       2
---------------------------------------------------------------------------
 1323- 1348 (43.68/33.02)	PdqATQLKWNVQFC..LTIPPSAPPIAP
 1352- 1377 (39.36/22.76)	P..AVVLKSKMLFFlqLTQKTSVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      10|      29|    1399|    1408|       3
---------------------------------------------------------------------------
 1399- 1408 (17.56/10.23)	PRQQNSSVAA
 1425- 1434 (19.77/12.51)	PRQGECTIFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.92|      14|      29|     166|     179|       5
---------------------------------------------------------------------------
  133-  149 (17.29/ 8.39)	RLASLARDALV....HarlPS
  166-  179 (25.87/17.19)	RLPTCIRDKII....P...PD
  192-  209 (18.77/ 9.91)	QLNQILRHRLVttdlP...PQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.75|      12|      29|     357|     368|       6
---------------------------------------------------------------------------
  357-  368 (20.47/12.55)	IKIDENDVSKPL
  388-  399 (20.28/12.37)	MKIDHLSIEKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.85|      28|      32|     507|     538|       7
---------------------------------------------------------------------------
  507-  538 (42.20/34.70)	IKHLPT..ITTETLQLSNYSTHpignLSKNKLFI
  540-  569 (45.65/26.76)	LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.42|      30|      32|     244|     273|       8
---------------------------------------------------------------------------
  226-  257 (41.73/27.06)	GEFEATLTVMGDDpeVPWRLLKLEILVEDKET
  258-  287 (49.69/33.72)	GDGRALVHSMQID..FIHQLVQSRLFADEKPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.42|      32|      32|      64|      95|       9
---------------------------------------------------------------------------
   64-   95 (51.02/34.02)	LLVLTDLLPRKSDVERKIEIVQFASRTRQLFV
   97-  128 (53.40/35.94)	LLALVKWANDAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.66|      20|      37|     291|     310|      10
---------------------------------------------------------------------------
  291-  310 (38.65/29.55)	YNCLHCFCLSL.QLEVLHSQT
  327-  347 (31.01/22.03)	YHAGKCLSLSVwNQQVLGRKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|    1244|    1258|      11
---------------------------------------------------------------------------
 1244- 1258 (21.47/18.36)	LKCRVALSP.KTNqTL
 1282- 1296 (22.14/12.96)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.07|      12|      34|     441|     452|      12
---------------------------------------------------------------------------
  441-  452 (23.64/13.22)	LEPCGNSECLHI
  476-  487 (22.43/12.21)	MEKCVNDDMKRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12486 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHNTINQSPSMIHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARLPGMSPANPSLHSPIPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
968
1167










Molecular Recognition Features






MoRF SequenceStartStop




NANANA