<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12483

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSFVSNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGKDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHVTLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCGLKEMSEEKQEDIDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGIHQVPASTRDPAMSSVTLTPPTSPEEVQAVDPQSAQKWVKFSSVSDGFSTDSTSHHGGKIPRKLANHVVDRVWQECNMNRLQNKRKYSATSSGLCEDESADKIACWDFVEATQRTSCSCLRHKSLKTRNTGQQGQAPSLGQQQQVLPKHKTSEKQEKNEKPQKRPLTPFHHRVSLSDAIGMDTDSASQRLVVSSADSQVRFSNIRTNDVAKTPQMHGTELANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPTKPMEDRIDSLSQSFPPPFQEAVEPTVYVGTAVNLQEDEANVAWKYYKVPKKKDVEFLPPQLPNDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDEIVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFIFTDKKDRQNSEREAGKKHKVEDGTSTVTVLSHEEDAMSLFSPSKQDAPRPTNHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSASGSDDKASSKEPKTGSLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTAPGGTVLEGNSSSIGAQFRIEVEEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSHCLPPIKLPEECIYRQSWTVGKLDLLPSGPSMPFIKEGDGSNMDQDYGPAYTPQTHTSFGMPPSSAPPSNGGTGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAENVNGGLKESEKVPDELILLLQDQCTNLFSPFGAADQDPFPKMGIISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWAKQNDVSVQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWEKLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMKVGATASKKLSEKFVTEWFSQAADSNNETFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTNQSLLTAPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTTSSSSSSNMSSGVSSNKLPSFPPFGSMNTSGSGSMSAQASTVQSGQLGGQQSSSLQAAGMSGELASLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYMIDPFSYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTPQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIISILPASPTASPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2171
PositionMiddle
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.08
Grand average of hydropathy-0.393
Instability index52.70
Isoelectric point5.45
Molecular weight238941.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000250	

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12483
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     284.58|      63|     421|     527|     589|       1
---------------------------------------------------------------------------
  468-  518 (54.13/25.80)	............PQKRPLTPfhHRVSLSDAIGM.DTDSA..SQRLV.VSSAD......SQVRF.SNIRtNDVAK
  519-  581 (115.51/65.53)	TPQMHGTELANSPQPPPLSP..HPCDVVDEGVT.KTPSTPQSQHFYQMPTPD......PLVPT.KPME.DRIDS
  582-  645 (73.60/38.40)	LSQSFPPPFQEAVEPTVY.........VGTAVNlQEDEANVAWKYYKVPKKKdveflpPQLPNdKFKD.DPVGP
  976- 1006 (41.34/17.51)	TPQTH.TSFGMPPSSAPPSN..G.....GTGIL.PSPSTP..................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.99|      25|      27|    1493|    1519|       3
---------------------------------------------------------------------------
 1493- 1519 (38.30/29.33)	TNTGNANTPSATLASAASStmTMTSGV
 1523- 1547 (41.69/25.05)	TSVATANSTLTTTSSSSSS..NMSSGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     407.57|     120|     715|     326|     451|       4
---------------------------------------------------------------------------
  326-  451 (202.37/137.26)	TP..PTSPEEVQAVDPQSAQKWVKFSSVSDGFSTDST........S..HHGGKIPRKLANH..VVDRVWQE..................CNMN..........................RLQNkRKYSATSSGLCEDEsADKIA....CWDfvEATQRtsCSCLRHKSLKTRNTG..QQGQAPS...LGQQQQ
  795-  852 (59.04/27.13)	....PGSKKSASGSDDKASSKEPKTGSL.DPLSCIST........AdlHKMYPTPPSLEQH..IMG..FSP..................MNMN....................................................................................................
 1013- 1194 (146.16/83.61)	TPrtPRTPR..GAGGPASAQGSVKYEN.SDLYSPASTpstcrplnS..VEPATVPSIPEAHslYVNLILSEsvmnlfkdcnfdsccicvCNMNikgadvgvyipdptqeaqyrctcgfsAVMN.RKFGNNSGLFLEDE.LDIIGrntdCGK..EAEKR..FEALRATSAENVNGGlkESEKVPDeliLLLQDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.02|      36|     421|    1555|    1606|       6
---------------------------------------------------------------------------
 1555- 1569 ( 2.67/ 6.25)	...............................................FPPfgsmNTSGSGSM
 1576- 1606 (28.22/17.63)	VQSGQLGGQQSSSlqaagmSGELASLPTQPH...............................
 1941- 1992 (56.13/22.75)	MQTPQLNTPQDTS......CTHILVFPTSASvqvasatyttenldlaFNP....NNDGADGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.29|      26|      27|     904|     930|       8
---------------------------------------------------------------------------
  904-  930 (47.10/33.00)	PENCqVLVGCSMFAPLKTLPS.HCLPPI
  933-  959 (46.20/27.40)	PEEC.IYRQSWTVGKLDLLPSgPSMPFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.45|      11|     943|     695|     705|       9
---------------------------------------------------------------------------
  695-  705 (21.12/11.69)	IDPYAFVEGDE
 1641- 1651 (21.33/11.89)	IDPFSYENKDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12483 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATANSTLTTTSSSSSSNMSSGVSSNKLPSFPPFGSMNTSGSGSMSAQASTVQSGQLGGQQSSSLQAAGMSGELASLPTQPHPDVSESTMDRDKVGIPTDGD
2) DLDNLFNSDEDELTPGSKKSASGSDDKASSKEPKTGSLDPL
3) FTDKKDRQNSEREAGKKHKVEDGTSTVTVLSHEEDAMSLFSPSKQDAPRPTNHARPPSTSLI
4) GPSMPFIKEGDGSNMDQDYGPAYTPQTHTSFGMPPSSAPPSNGGTGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
5) LRHKSLKTRNTGQQGQAPSLGQQQQVLPKHKTSEKQEKNEKPQKRPLTPFHHRVSLSDAIGMDTDSASQRLVVSSADSQVRFSNIRTNDVAKTPQMHGTELANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPTKPMEDRIDSLSQSFP
6) SPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
1526
781
709
953
427
2019
1626
821
770
1038
587
2049










Molecular Recognition Features






MoRF SequenceStartStop




NANANA