<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12482

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESERLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNATPLDKILHGSVGYLTPRSGGHLMNIKYYASPSDLLDDKTASPIILHEKNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSVTSANSVDLPACFFLKFPKPIPVSKTFVQKLQNCTGIPLFETPPTYVPLYELITQFELSKDPDPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGQSLQGTLVSKITFQHPGRVPLILNMIRHQVAYNTLIGSCVKRTVLKEDTPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMATGNNPMSGTTTPTNTFPGGPITTLFNMSMSIRDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRVPPDKSKHQTEDDFQRELFSMDVDSQNPMFDVSMTADALDTPHITPAPSQCSTPPTTYPQTVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTNDDCPPIGTPVRDSSSSGHSQSALFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKSSGQADTVDFSIISVAGKALGPADIMEHHSGSQSPLMATGELGKEKTQKRVKEGNGTGGGSGSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSHSQYSSSGSVSSSGSKSHHSHSSSSSSSSSASTSGKMKSSKSEGSSSSKLSGSMYSSQGSSGSSQSKNSSQTGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPCLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSSGPHMSGTSSSSGIKSSSGSGSSGSLSQKTPPASNSCTPSSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDSQMGVSTNSSSHPMSSKHNMSGGEFQSKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQIASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNVDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQTLSMTNNPILSADRPSRLSPDFMMGEEDDDLMDVALIGN
Length1580
PositionMiddle
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.04
Grand average of hydropathy-0.681
Instability index53.29
Isoelectric point8.90
Molecular weight168190.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12482
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     317.41|      42|      42|    1083|    1124|       1
---------------------------------------------------------------------------
 1024- 1098 (46.85/10.71)	HSSSNRPFTPPTST.....G..........GSK.....SPGSSgrsqtppgvatppipkitiqipkgtvmvgkpshsqyS...SSGSVSSSGSKSHHS
 1099- 1145 (50.45/12.21)	HSSSSSSSSSASTS.....GKMK.......SSK.....SEGSS...........................ssklsgsmyS...SQGSSGSSQSK....
 1194- 1247 (39.29/ 7.57)	PSHSRPPGGSDKLA.....SPMKpvpgtppSSKakspiSSGSS.....................................gphMSGTSSSSGIKS..S
 1248- 1289 (54.50/13.90)	SGSGSSGSLSQKTP.....PASN.......SCT.....PSSSS...................................fS...SSGS.SMSSSQNQHG
 1290- 1340 (36.41/ 6.37)	SSKGKSPSRNKKPSltaviDKLK.hgvvtsGPG.....GEDPM....................................D...SQMGVSTNSSS..HP
 1398- 1445 (46.90/10.73)	HDGGSPSIKAKVTL.....QKPG.......ESS.....GEGLR..............................pqiassK...NYGSPLISGSTPKHE
 1446- 1497 (43.02/ 9.12)	RGSPSHSKSPAYTP.....QNVD.......SES.....ESGSS..........................iaeksyqnspS...SDDGIRPLPEYSTEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     227.06|      53|      53|     696|     748|       2
---------------------------------------------------------------------------
  593-  658 (46.41/17.38)	EDF.S.KV.....SQNPILTslLQITGNGGSTigssptpPHHTPPPvSSMAGN........tknH.PmlmNLLKDNPAQDFS.
  659-  710 (51.96/20.57)	TLYgSSPL....ERQNSS.S..GS...................PRM.EMCSGSnktkkkkssrvP.P...DKSKHQTEDDFQR
  711-  765 (72.06/32.12)	ELF.SMDV....DSQNPMFD..VSMTADALDT.......PHITPAP.SQCSTP...pttypqtvPhP...QPS.......IQR
  819-  880 (56.63/23.25)	ALF.DSDVfqtnNNENPYTD.pADLIADAAGS.......PS.SDSP.TNHFFP......dgvdfN.P...DLLNSQSQSGFGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     193.62|      49|      53|     354|     406|       3
---------------------------------------------------------------------------
  311-  353 (53.89/27.67)	.IP..VS...KT..FVQKL...QNCT.......GIP..LF.ETPPTYVPLYELITqFelsKDPD
  354-  402 (92.93/48.37)	PLP..LN...HNMRFYAALPGQQHCY...FLNKDAP..LP.DGQSLQGTLVSKIT.F...QHPG
  405-  457 (46.80/25.64)	P..liLNmirHQVA.YNTLIGS..CVkrtVLKEDTPglLQfEVCPLSESRFS.VS.F...QHP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.78|      30|     156|     991|    1023|       4
---------------------------------------------------------------------------
  952-  976 (34.83/10.80)	GSQSPLMATGELGKEKTQK.....RVK...EGN...
  993- 1023 (50.82/32.18)	GKRSRTPSNDGKSKDKPPK.....RKKADTEGKsPS
 1047- 1078 (45.12/18.13)	G.RSQTP..PGVATPPIPKitiqiPKGTVMVGK.PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.46|      18|      20|    1343|    1360|       6
---------------------------------------------------------------------------
 1343- 1360 (32.34/15.35)	SKHNMSGGEFQSKREKSD
 1364- 1381 (29.12/13.05)	SKVSTSGGSVDSSKKTSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.63|      17|      22|     541|     558|       7
---------------------------------------------------------------------------
  541-  558 (29.75/19.81)	PPASSPGYGMATGNNpMS
  563-  579 (33.88/17.57)	PTNTFPGGPITTLFN.MS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.85|      44|      65|     153|     197|       8
---------------------------------------------------------------------------
  165-  213 (67.87/47.59)	GDNKLKTKMYLALQSLEQDLSKMAIMYWKATNA....tpldkILHGSVG.YLTP
  216-  269 (61.98/48.07)	GGHLMNIKYYASPSDLLDDKTASPIILHEKNVPrslgmnasvTIEGTSAmYKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.66|      19|      22|    1147|    1165|       9
---------------------------------------------------------------------------
 1147- 1165 (37.50/15.74)	SSQTGGKPGSSP..ITKHGLS
 1168- 1188 (31.15/11.69)	SSSTKMKPQGKPssLMNPCLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.24|      19|     405|      48|      69|      10
---------------------------------------------------------------------------
   48-   69 (26.62/22.42)	VVMSSGGHQHlVSCleTLQKAL
  465-  483 (35.62/18.92)	VVMDVQDSTH.VSC..KLYKGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.71|      10|      54|    1472|    1481|      14
---------------------------------------------------------------------------
 1472- 1481 (16.78/ 7.02)	IAEKSYQNSP
 1527- 1536 (16.94/ 7.17)	IKPENWSKSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12482 with Med1 domain of Kingdom Metazoa
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