<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12481

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASASDPMNALQSLTGGPTPGTAGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQHLQQQQQHLIKLHHQSQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPPMQQPPPPPSQALPQQLQQMHHPQHHQPPPQAQQSPVAQNQAPQLPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQQQAAVQTAQAAQMVAPGVQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIMSPVVCSRKRRFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGAVHLICKLDDKDLPSVPPLEISVPADYPAQSPMWIDHQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length743
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.03
Grand average of hydropathy-0.693
Instability index88.72
Isoelectric point9.27
Molecular weight81867.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12481
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.58|      19|      21|     161|     180|       1
---------------------------------------------------------------------------
  161-  180 (35.72/ 9.36)	QQQQQQQQQFQQQQAaLQQQ
  262-  280 (34.85/ 6.36)	QQPPMQQPPPPPSQA.LPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     361.21|      60|      60|     181|     240|       2
---------------------------------------------------------------------------
  185-  247 (98.85/26.52)	QQQQQQQFQAQQNA......MQQQ...................FQAVVQQQHLQQQQQHLI.....KLHHQSQ.QQIQQQQLQR..........MAQlqlQQQQ
  248-  308 (63.87/13.63)	QQQQQQALQA.QPP......M...qqppmqqpppppsqalpqqLQQMHHPQH.................HQPP.PQAQQSPV.............AQ..nQAPQ
  311-  360 (83.16/20.74)	PQSQSQPLVSQAQA......LPGP...................M......LYAAQQQLKFV.....RA....P.MVVQQPQVQP..........QVQ...QVQP
  361-  404 (57.37/11.24)	QVQQQAAVQTAQAA..............................QMV..APGVQVSQSSLT.....MLSSPSPgQQVQTPQ.......................
  416-  486 (57.96/11.45)	PGSQPNSNVSSGPApspssfLPSP...........................SPQPSQSPVTartpqNFSVPSP.GPLNTP.VNPssvmspagssQAE...EQQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.30|      17|      22|      95|     116|       3
---------------------------------------------------------------------------
   95-  116 (22.71/25.45)	GTAGiGMPPrgPGQSlgGMG..GL
  123-  141 (31.59/14.87)	MPLS.GQPP..PGTS..GMAphGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.96|      20|      22|     569|     588|       4
---------------------------------------------------------------------------
  541-  564 (26.18/10.05)	QK..CEIALEklkndmAVPT....PPPPPV
  569-  588 (35.00/15.91)	QQDLCQPLLD......AVLA....NIRSPV
  590-  613 (29.78/12.44)	NHSLYRTFVP......AMMAihgpPIMSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.20|      18|      22|     637|     654|       5
---------------------------------------------------------------------------
  637-  654 (32.82/19.43)	VARLDPKFLVNLDPSHCS
  662-  679 (32.38/19.07)	ICKLDDKDLPSVPPLEIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      27|     701|     711|       6
---------------------------------------------------------------------------
  701-  711 (23.12/12.66)	NPFLQSVHR.CM
  729-  740 (18.67/ 8.95)	NTWAQSIHQaCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12481 with Med15 domain of Kingdom Metazoa
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