<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12477

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLISEEHLHMAQSSPAPFQVLVSPYGLNGTLTGHAYKMSDPATRKLIEEWQYFYPMVLRKKEESREEAELGYDDDFPVAVEVIVGGVRMIYPSAFVLIAQNDIPVPQTATSVGGHVTVGQQGLGNVKDPSNCGMPLTPPTSPEQVAIGESGGVQSAASHLSSQDGGMITMHSPKRSRKIPPKLHNHMVHRVWKECILNRAQAKRSQVSTPTREEEPAHNPAAWDFVDPTQRVSCSCSRHKLLKRCTIGPSRTPTVSQPGFSAGPPSSSSLPPPASSKHKTAERQEKGDKLQKRPLVPFHHRPSVAEELCMEQDASGQKLGLAGIDASLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALYGSGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYSGIRPSYTESSDKWWQGFRLPPSEDTEFRPPELQGDRFDTKLDVNPESTALQRLLAQPNKRFKIWQDEQPQVQPLPFLDPSPLSQQPGDTLGEVNDPYTFEDGDIKYIFTANKKCKQGPEKDTLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKVPAVGTEERPPGKEGRAAGPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGVNSETVTALGMMESPVVSMVPTHFSEFRMEVEDGLGSPKPEEIKDFSYVHKVPQFQPFVGSSMFAPLKTLPSHCLLPLKTPDACLFRPSWAVPPKMEQLPMPPAAASIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNVFKDRNFDSCCICACNMNIKGADVGLYIPDSSKEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSSFLPQMEGARKSPEPPISLLLLLQNQHTQPFASLSFLDYISSNSRHALPCVSWTYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHCWPHSNVLDTSMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKEFLTISPFSLPFWERLLLEPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTLAQKLTEELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSGLLMPPKHQSPPAEAQGQATPGNAGSLPSNAGSVAPPAGSAFNPTSNSSANPAASSSSASSGPSGSSTASAPGITQMNTTSSSGFSGGVGGQNPSAGGSSADRAPGNVACGDTEPGQSSTQPSQDGQDSVTDRERIGIPTEPDSADSHAYPPAVVIYMVDPFTYTAEEDSSSGNFWLLSLMRCYTEMLDHLPEHMRSSFILQIVPCQYMLQTMKDEHVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTEPGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRSRKSKVSARKIGLQKLWEWCLGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQARNQCPLFLKASLHHHISVAQTDELLPARNSQRAPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNML
Length2208
PositionMiddle
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.07
Grand average of hydropathy-0.400
Instability index58.11
Isoelectric point5.75
Molecular weight242197.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12477
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.79|      27|      28|    2068|    2095|       1
---------------------------------------------------------------------------
 2068- 2095 (41.86/31.18)	HFQhSRSQGERL...LSREAPEELKQQPLAL
 2097- 2126 (45.94/28.88)	YFV.STAKAENLpqwFWSSCPQARNQCPLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.76|      27|      29|    1010|    1036|       2
---------------------------------------------------------------------------
 1010- 1036 (49.41/25.34)	PDYLNTPQMNTPVTLNSTAPASNSGAG
 1041- 1064 (45.14/22.41)	P...ATPRFSVPTPRTPRTPRTPRGGG
 1080- 1098 (26.21/ 9.43)	GSPASTPSTTRP..LNSVEPA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.28|      28|      29|    1124|    1151|       3
---------------------------------------------------------------------------
 1124- 1151 (54.86/38.84)	KDRNFDSCCICACNMNIK.GADVGLYIPD
 1154- 1182 (48.42/33.30)	KEDQYRCTCGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.10|      18|      21|    1565|    1585|       4
---------------------------------------------------------------------------
 1565- 1582 (33.19/10.55)	PTSNS.......SANPAASSSSASS
 1600- 1624 (25.91/ 7.64)	TTSSSgfsggvgGQNPSAGGSSADR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.02|      19|      21|     651|     669|       5
---------------------------------------------------------------------------
  651-  669 (31.40/20.45)	LQGDRFDTKLDVNPESTAL
  675-  693 (35.62/24.38)	QPNKRFKIWQDEQPQVQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.93|      20|      21|     949|     969|       6
---------------------------------------------------------------------------
  949-  969 (34.27/19.63)	MFAPLKTLPSH.CLLPLkTPDA
  971-  991 (35.66/16.58)	LFRPSWAVPPKmEQLPM.PPAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.27|      22|      30|    1850|    1878|       7
---------------------------------------------------------------------------
  357-  378 (40.11/16.55)	ITMHSPKRSRKIPPKLHNHMVH
 1854- 1875 (34.16/25.59)	VNIALPSRSRKSKVSARKIGLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.54|      20|      24|    1692|    1715|       8
---------------------------------------------------------------------------
 1692- 1715 (30.31/37.71)	SSgnfWLLSLMRCYTeMLDHL.PEH
 1718- 1738 (34.23/24.22)	SS...FILQIVPCQY.MLQTMkDEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.19|      12|      23|     543|     554|       9
---------------------------------------------------------------------------
  543-  554 (25.15/12.08)	NPMDSPHSPISP
  569-  580 (23.04/10.25)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.83|      16|      16|    1224|    1239|      10
---------------------------------------------------------------------------
 1224- 1239 (27.34/17.65)	SLLLLL..QNQHTQPFAS
 1241- 1258 (24.49/14.88)	SFLDYIssNSRHALPCVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1266|     156|     189|      12
---------------------------------------------------------------------------
  156-  189 (52.23/48.15)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1425- 1456 (59.04/43.59)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.21|      56|     135|     703|     765|      13
---------------------------------------------------------------------------
  703-  760 (96.56/52.52)	QQPGDTLGEVN.........................DPYTFEDGDIKYIFTANKKCKQGPEKDTLKKNKseDGFGTKDVTTPG
  816-  896 (85.65/35.82)	NSDDDELGAVSpalrsskvpavgteerppgkegraaGPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYK..DGVNSETVTALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.17|      15|      17|    1633|    1649|      15
---------------------------------------------------------------------------
 1633- 1649 (23.72/20.24)	DTEPGQSSTQPsqDGQD
 1653- 1667 (27.45/16.01)	DRERIGIPTEP..DSAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      28|    2017|    2039|      16
---------------------------------------------------------------------------
 2017- 2039 (24.82/20.86)	SPNNDdmfvDLPFPDDmDNDIGI
 2048- 2065 (34.25/14.06)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.77|      11|      16|     603|     614|      17
---------------------------------------------------------------------------
  603-  614 (15.91/13.02)	GQRlPLMAEVSE
  620-  630 (20.86/11.85)	GIR.PSYTESSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.29|      18|      30|     462|     479|      20
---------------------------------------------------------------------------
  462-  479 (29.69/16.85)	PASSKHKTAERQEKGDKL
  491-  508 (30.60/17.59)	PSVAEELCMEQDASGQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      11|      28|    1517|    1527|      22
---------------------------------------------------------------------------
 1517- 1527 (20.27/11.74)	LQLDSGLLMPP
 1548- 1558 (20.24/11.71)	LPSNAGSVAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.09|      57|     178|    1275|    1334|      23
---------------------------------------------------------------------------
 1275- 1334 (91.10/60.33)	CfNALEQGRQYVDNPTGGKVDEALVRSATVHCWPHSNVLDTSMLS.SQDVVRmlLSLQPFL
 1457- 1514 (97.99/54.95)	C.KVLRDGIMRVGKTLAQKLTEELVSEWFNQPWSSEENDNHSRLKlYAQVCR..HHLAPYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.55|      18|      26|    1340|    1357|      24
---------------------------------------------------------------------------
 1340- 1357 (33.04/17.86)	KKRTGRTWENIQHVQGPL
 1363- 1380 (32.51/17.45)	HKMAGRGTYGSEESPEPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12477 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CTIGPSRTPTVSQPGFSAGPPSSSSLPPPASSKHKTAERQEKGDKLQKRPLVPFHHRPSVAEELCMEQDASGQKLGLAGIDASLEV
2) FKIWQDEQPQVQPLPFLDPSPLSQQPGDTLGEVNDP
3) FRLPPSEDTEFRPPELQGDRFDTKLDVNPESTALQR
4) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
5) KMEQLPMPPAAASIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
6) KQGPEKDTLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKVPAVGTEERPPGKEGRAAGPYPPTVADLQRMFPTPPSLEQHPAFSPVMNY
7) SGLLMPPKHQSPPAEAQGQATPGNAGSLPSNAGSVAPPAGSAFNPTSNSSANPAASSSSASSGPSGSSTASAPGITQMNTTSSSGFSGGVGGQNPSAGGSSADRAPGNVACGDTEPGQSSTQPSQDGQDSVTDRERIGIPTEPDSA
8) SSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALY
9) TATSVGGHVTVGQQGLGNVKDPSNCGMPLTPPTSPEQVAIGESGGVQSAASHLSSQDGGMITMHSPKRSRKIPPKLH
434
680
636
2038
981
734
1521
521
297
519
715
671
2086
1101
883
1666
583
373










Molecular Recognition Features






MoRF SequenceStartStop




1) KRFKIWQ
678
684