<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12473

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASASDPMNALQSLTGGPTPGTAGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQHLQQQQQHLIKLHHQSQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPPMQQPPPPPSQALPQQLQQMHHPQHHQPPPQAQQSPVAQNQAPQLPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQQQAAVQTAQAAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSVCVGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIMSPVVCSRKRRFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGAVHLICKLDDKDLPSVPPLEISVPADYPAQSPMWIDHQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length783
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.03
Grand average of hydropathy-0.655
Instability index87.57
Isoelectric point9.29
Molecular weight85836.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12473
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.44|      16|      17|     213|     229|       2
---------------------------------------------------------------------------
  213-  229 (26.85/ 6.95)	QQQQQHLiKLHHQSQQQ
  249-  264 (31.59/ 6.85)	QQQQQAL.QAQPPMQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     237.36|      43|      44|     418|     460|       3
---------------------------------------------------------------------------
  268-  307 (58.67/14.37)	QPPPPPS..Q......ALPQQLQQMHHPQ.............HHQPPPQ...AQQSPVAQnqaP
  418-  460 (83.80/24.26)	QPTAQVS..QSSLTMLSSPSPGQQVQTPQ.............SMPPPPQ...PSPQPGSQ...P
  469-  507 (53.92/12.50)	AP....S..PSSF..LPSPSP.QPSQSPV.............TARTPQNfsvPSPGPLNT...P
  553-  610 (40.97/ 7.41)	DRKKDLSkmKSLLDILTDPSKRCPLKTLQkceialeklkndmAVPTPPP...PPVLPTKQ...Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.05|      16|      26|     100|     124|       4
---------------------------------------------------------------------------
   83-  103 (25.16/ 6.71)	NALQSLT........GGPTPgtagiGMPP
  105-  130 (23.90/14.98)	GPGQSLGgmgglgamGQPMP...lsGQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.02|      17|      36|     195|     211|       6
---------------------------------------------------------------------------
  195-  211 (31.97/10.31)	QQNAMQQQFQAVVQQQH
  231-  247 (29.05/ 8.49)	QQQQLQRMAQLQLQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      27|     741|     751|       7
---------------------------------------------------------------------------
  741-  751 (23.12/12.20)	NPFLQSVHR.CM
  769-  780 (18.67/ 8.62)	NTWAQSIHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.20|      18|      27|     677|     694|       8
---------------------------------------------------------------------------
  677-  694 (32.82/20.45)	VARLDPKFLVNLDPSHCS
  702-  719 (32.38/20.06)	ICKLDDKDLPSVPPLEIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.82|      14|      27|     615|     628|       9
---------------------------------------------------------------------------
  615-  628 (24.17/13.27)	PLLDAVLA....NIRSPV
  636-  653 (21.65/11.12)	TFVPAMMAihgpPIMSPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12473 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASASDPMNALQSLTGGPTPGTAGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTAT
2) QPQVQPQVQQVQPQVQQQAAVQTAQAAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSVCVGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQAQPPMQQPPMQQPPPPPSQALPQQLQQMHHPQHHQPPPQAQQSPVAQNQAPQLPPQSQSQPLVSQAQALPG
70
348
248
148
533
327










Molecular Recognition Features






MoRF SequenceStartStop




NANANA