<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12468

Description mediator of RNA polymerase II transcription subunit 23 isoform X2
SequenceMVPMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWNGLSQDSHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDDSNLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQRSTHLNYMDPICDFLYHVKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAPPQALNSGSPAPQATQVPASLPVTQ
Length1370
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.10
Grand average of hydropathy-0.002
Instability index47.04
Isoelectric point6.92
Molecular weight156566.32
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12468
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.24|      49|     262|     974|    1029|       1
---------------------------------------------------------------------------
  980- 1029 (85.65/72.30)	LLPVSKSLETLL..DHLGG..LYKF.HDRPVTYLYNTLHYYEMCLrNRDHLKRKL
 1238- 1291 (73.59/44.11)	LLPVVKTEFQLLyvYHLVGpfLQRFqQERTRCMIEIGVAFYDMLL.NVDQRSTHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.14|      45|     262|     525|     576|       2
---------------------------------------------------------------------------
  449-  503 (67.60/44.08)	PIP....HSLKLHHEF.LQQSLRNKSLQMNDYK..IALLCNAYSTNSEcftLpmgalveTIY
  525-  576 (59.53/58.53)	PLPmnllDSLTVHAKMsLIHSIATRVIKLAHAKssVALAPALVETYSR...L.......LVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      18|     127|     908|     925|       3
---------------------------------------------------------------------------
  908-  925 (38.81/24.32)	KENSPEHWLQNDWHTKH.M
 1038- 1056 (33.13/19.63)	KDNRPQGWCLSDTYLKHaM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.70|      20|     262|     826|     853|       4
---------------------------------------------------------------------------
  831-  850 (36.70/38.59)	DFLV...YEFSTSAGGQQLNKCI
 1299- 1321 (31.00/10.32)	DFLYhvkYMFTGDSVKEQVEKII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.87|      21|     127|     587|     611|       5
---------------------------------------------------------------------------
  587-  607 (36.35/27.02)	FISQLLPTVFKSHAWGILHTL
  613-  633 (38.51/18.25)	YRMHHIQPHYRVQLLSHLHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     160.37|      34|     128|     932|     966|       6
---------------------------------------------------------------------------
  195-  227 (46.77/21.42)	PEgKLPH.WLLGNLVSDFVDTFRPTARI..NSICGR.
  932-  966 (58.86/32.94)	PE.KLYF.EGLAEQVDPPVPIQSPYLPIyFGNVCLRF
 1066- 1097 (54.74/26.16)	PE.DSYYcKLIGRLVDTMAG.KSPG.P..FPNCDWRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.13|      65|     377|     724|     795|       8
---------------------------------------------------------------------------
  724-  763 (59.92/28.36)	...............................................................................................................................................................................................................................................................................................................................................NFTPHNWASHTLSC.FPAPL.QAFFKQNNVPQESRFNLKKNV
  764-  795 (17.40/18.00)	EEEYRKWksMTDENEIITqfsvqGFP.PLFLCL........................................................................................................................................................................................................................................................................................................................................................
 1098- 1132 (42.86/17.69)	.................................lwkmlletdhisqigyrvlerigaralvahvrtfadflvyefstsaggqqlnkcieilndmvwkynivtldrlilclamrshegneaqvcyfiiqllllkpndfrnrvsdfvkenspehwlqndwhtkhmsyhkkypeklyfeglaeqvdppvpiqspylpiyfgnvclrflpvfdivihrflellpvsksletlldhlgglykfhdrpvtylyntlhyyemclrnrdhlkrklvhaiigslkdnrpqgwclsdtylkhamnarednpwvpedsyyckligrlvdtmagkspgpfpncdwrfNEFP.NPAAHALHV.TCVEL.MAL....AVPGKDVGNALLNV
 1142- 1228 (65.95/33.87)	RENITAW..MNAIGLIIT.....ALPePYWIVL...................................................................................................................................................................................................................................................................................hdrivsvisspsltsetewvgypfrlfDFTACHQSYSEMSCsYTLALaHAVWHHSSIGQLS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.05|      10|      27|     138|     147|       9
---------------------------------------------------------------------------
  138-  147 (15.61/10.01)	RDLLKVILEK
  167-  176 (16.44/10.95)	REVIAYILER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12468 with Med23 domain of Kingdom Metazoa
Unable to open file!