<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12466
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MRLLAIAWAMAASSSGEKEKERLGGVSVMAGVGSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQLDEENQVLELLIHRDGDFQELMKLALNQGKVHHEMQALEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTSGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSSDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD |
Length | 270 |
Position | Middle |
Organism | Mesocricetus auratus (Golden hamster) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea>
Cricetidae> Cricetinae> Mesocricetus.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.511 |
Instability index | 47.71 |
Isoelectric point | 5.02 |
Molecular weight | 30803.43 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP12466
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.87| 24| 24| 223| 246| 1
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223- 246 (45.93/28.60) D.VLAPQYPWQSNDMSVNMLPPNHS
248- 272 (36.94/21.76) DfLLEPPGHNKENEDDVEVMSTDSS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 103.64| 24| 24| 103| 126| 2
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73- 95 (34.99/21.87) QVLELLI.HRDGDFQELMKLALNQ
103- 126 (36.41/23.00) QALEKEVEKRDSDIQQLQKQLKEA
128- 151 (32.24/19.68) QILATAVYQAKEKLKSIEKARKGA
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