<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12465

Description mediator of RNA polymerase II transcription subunit 23 isoform X1
SequenceMVPMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWNGLSQDSHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDDSNLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQRSTHLNYMDPICDFLYHVKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAPPQALNSGSPAPQATQVPASLPVTQ
Length1376
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.10
Grand average of hydropathy-0.000
Instability index47.20
Isoelectric point6.92
Molecular weight157207.05
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12465
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.76|      47|     142|     244|     298|       1
---------------------------------------------------------------------------
  192-  242 (49.65/23.89)	KLYPEG.KLPhwLLGNLVSDfVDTFRP.TARINSICG.RcsllP.VvnNSGAIC...N....
  245-  292 (82.48/68.11)	KLDPATlRFP..LKGLLPYD.KDLFEPQTALLRYVLE.Q....P.Y..SRDMVC...NMLGL
 1121- 1160 (36.63/13.96)	............LMALAVPG.KDV...GNALLNVVLKsQ....PlV..PRENITawmNAIGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.24|      49|     262|     980|    1035|       2
---------------------------------------------------------------------------
  986- 1035 (85.65/72.50)	LLPVSKSLETLL..DHLGG..LYKF.HDRPVTYLYNTLHYYEMCLrNRDHLKRKL
 1244- 1297 (73.59/44.23)	LLPVVKTEFQLLyvYHLVGpfLQRFqQERTRCMIEIGVAFYDMLL.NVDQRSTHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.61|      24|      89|    1076|    1101|       3
---------------------------------------------------------------------------
 1076- 1101 (44.03/40.92)	YYCKLIGRLVDTMAgkSPGPFPNCDW
 1169- 1192 (43.57/32.32)	YWIVLHDRIVSVIS..SPSLTSETEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.84|      32|     373|     933|     973|       4
---------------------------------------------------------------------------
  933-  973 (50.88/56.54)	YHKKYpeklYFEG..LAEQVDPPVPIQSPYLPIYfgnvcLRFL
 1308- 1341 (53.97/34.97)	YHVKY....MFTGdsVKEQVEKIICNLKPALKLR.....LRFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      18|     127|     914|     931|       5
---------------------------------------------------------------------------
  914-  931 (38.81/24.65)	KENSPEHWLQNDWHTKH.M
 1044- 1062 (33.13/19.91)	KDNRPQGWCLSDTYLKHaM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.14|      45|     262|     531|     582|       6
---------------------------------------------------------------------------
  455-  509 (67.60/50.04)	PIP....HSLKLHHEF.LQQSLRNKSLQMNDYK..IALLCNAYSTNSEcftLpmgalveTIY
  531-  582 (59.53/66.48)	PLPmnllDSLTVHAKMsLIHSIATRVIKLAHAKssVALAPALVETYSR...L.......LVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.04|      19|      81|     783|     801|      10
---------------------------------------------------------------------------
  783-  801 (34.60/21.53)	NEIITQFSVQGFPPLFLCL
  860-  878 (34.44/21.39)	NDMVWKYNIVTLDRLILCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.88|      36|      81|     593|     628|      11
---------------------------------------------------------------------------
  593-  621 (42.49/24.39)	..........FISQL..LP.TVFKSHAWGILHTLLEMFSYRM
  622-  661 (45.43/26.63)	HHIQPHYrvqLLSHLhtLA.AVAQTN.QNQLHLCVESTALRL
  668-  703 (39.95/22.46)	SEVQPQF.trFLSD....PkTVLSAESEELNRALILTLA.RA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12465 with Med23 domain of Kingdom Metazoa
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