Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MENFTALFGAQADPQPPPSALGFGPGKPPPPPPPPPGGGPGTAPPPTATSATAGADKSTAGSGPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFNPITGTMLSGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR |
Length | 244 |
Position | Head |
Organism | Mesocricetus auratus (Golden hamster) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.056 |
Instability index | 65.22 |
Isoelectric point | 9.88 |
Molecular weight | 26367.72 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP12463 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 79.46| 25| 115| 99| 130| 1 --------------------------------------------------------------------------- 99- 130 (34.66/25.26) KKVKEKLSnflPDLPGMidlpGSHDNSSLRSL 219- 243 (44.80/18.37) KKKKNRHS...PDHPGM....GSSQASSSSSL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 50.21| 16| 16| 170| 185| 2 --------------------------------------------------------------------------- 170- 185 (28.42/14.80) PPK...KKNKHKHKQSRTQ 189- 207 (21.78/ 9.74) PPEtpsDSDHKKKKKKKEE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDH 2) MENFTAL | 195 1 | 229 7 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab