<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12458

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWRAFLHQCLMRRIDAAEFKNLSKILFRRCPTAEGTLLDVLLEIRLATGIKWDPLLPLYIDCLCKMGKVQTSTVLTSLLKYSSIHDKPQSPSSETVQSKMALKCYTLMTDIRVIQDAMLSVSTGSTPKSLAEAVGIFSAIIDWIQAVVAWHNNHIDPSQQTGGLMSSPDAVSLFESLGILLTALSGTGKGIEVLSSDSHEALKVKLGQALSAYLPLCMEVSLPLRNRLDSLQKGFNLYGEPPNKSLQSMMDNVNVNALQFEASVMDGPVINSRAGLYIYINAMLVGRPLVDDSMLLNYLTNRYGGHYDVLVEEVITATFDVLSNALYRNESSRTMFLFRSFLVNKLPSFFAAMLAASMVSLPMEMCISHALSRLDPNTFPSFSQMFAMQGSTVLSEVRPEFLFACASHKLIPESSIERLLGENPMQTPPVGYNKDDLVSQINTNQERAEQLVSELESTEGNAGAIVAAITEVMHNLCNQKETMTLKSICNSLSRRPQALDVILLFRSAKQVLQPLCALLDSWHWDEDQGESQPVYDEFGSILLLVLTFKYRYDLRPYDLGITSNDSFVLKLLDCGSSSQNLDDLSEKQNRNLGAWITALFIAEGISEETMSSCSPQEFYLLVTTLFNQSLTACEAGKLEFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWETESDPTIPLKTLQSLVNPSSISGDAREIHKTVLNITARSLDEQLKDIRSRHPNRADIKPILDVLEPCLSFQRTGSCHRSELDSWTTHSPGGLLGSIRSTFQGLVLWSTSPGVSMAPHSYTHRQLVAGIRMLGSARVLTAIVDELKMQTETGNADLALDIAVTMICAPLAESFAIEQSNYHPVDPNKEPLPRCPVLTLRDALNLQHENVPKLSEKDPLRAEVIVRLYRRVNALMTPTSQMPNLDMSNIIQDMQLGVEDHGQMDLEPAGAGHGVGDDDAANLNRMLDNAAAAAAAGLDSGMGQGMGGGLDTSIDDVLNAADMAVGNPEFLDLDMEGMF
Length1013
PositionTail
OrganismAspergillus oryzae (Yellow koji mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.06
Grand average of hydropathy-0.032
Instability index50.52
Isoelectric point4.90
Molecular weight111422.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12458
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     441.25|     142|     296|     397|     593|       1
---------------------------------------------------------------------------
  397-  548 (220.11/238.95)	TVLSEVrpefLFACASHKL...IPESSIERLLgeNPMQTPPVGYNKDDLVSQINTNQERAEQLVSELESTEgNAGAIVAAITEVMH...NLCNQKETMTLKSICnslSRRPQALDVILLFRSAKQVLQ....PLC..ALLDSWHWDEDQGESQPVYDEFGSILL
  629-  782 (221.14/134.76)	TLFNQS....LTACEAGKLefdTLKGGFEYLL..EPFLLPSLVVALTWLGNHIWETESDPTIPLKTLQSLV.NPSSISGDAREIHKtvlNITARSLDEQLKDIR...SRHPNRADIKPILDVLEPCLSfqrtGSChrSELDSWTTHSPGGLLGSIRSTFQGLVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.58|      34|      42|     292|     333|       2
---------------------------------------------------------------------------
  252-  287 (53.94/40.27)	QSMMDNVNVNALQFEASVMDGPVINsrAGLYIYINA
  297-  330 (57.64/40.05)	DSMLLNYLTNRYGGHYDVLVEEVIT..ATFDVLSNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.19|      80|     152|      15|      97|       3
---------------------------------------------------------------------------
   15-   97 (128.01/78.45)	LMRRIDAAE.FKNLSKILFRRCPTAEGtlLDVL.LEIRLATGIKWDPLLPLYIDcLCKMGKVQTSTVLTSLLKYSSIHDKPQSPS
  169-  250 (125.18/67.55)	LMSSPDAVSlFESLGILLTALSGTGKG..IEVLsSDSHEALKVKLGQALSAYLP.LCMEVSLPLRNRLDSLQKGFNLYGEPPNKS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12458 with Med5 domain of Kingdom Fungi
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