<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12447

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMIMDDGINVDDLFGESASLELGLPATAPTSNSTKGLAQRLDEMRLLGCCQKIAWSKQGCIAYISQDTLRVNLRHLECRPSDGKWVLSDDTPLHPVAEAHGGQPLVHLCWNEIGSELAVVDSSGRVSIYNIAISLNSLAGQRQAAFDPVDDATQIVGMMWLNIQRSVSAHFGVSPMFGPFHPAGKAALLCVTRSGIIRLLYQNPDNKWAEISAELKNASYSDRLLTHAAIVATQNGILIATYSACQKIYFYRVQINWTPPQWDPSQLKQAPNQFPVPSFRFMHSKVEAPCIIPSASRNGEATNDGMPSSTNPLYCLTRLDIVLAAHDNSAGMTTNPWIIAVFSIPPHATPDHSQQQSPCSVIVRWQLESAPQVLHPKFDEVNAKKNNAQIKPKSVLRRQEDMYCDRYVTMIEQTEHGNVLAVTYDDSSVTFYDPKTMAVLNGTDDTNTLTSLAHAGFQYPPDSAGSFPSRYRGGTKFDTSIAGLHISFSPSGCNAVTLDGEGQAQLRVMEHSYGAENGLYDENKFSAAVASLTLAFCRGCGSEFNTDDILLILKRQASPDAQISFINEVYRALGVNCNYTQENDKLMSHQYLPKCLSVQAALGFIDKYKSRNFASNVPWTILQLRHASVLYALFLQYLKGGVQAEPPDADAIRILLGNTKWALDLLHYVLNDLLDLADDLESLLSDQEAFAQKLKTISSLPLIILLSSMSRAFLRFICRGLRGIQAGYATAPLTGDAGVYYAEIYRTLDTSPVRIDVYEKLLAGVDSTVRHVYHGAGFGDNERPGPEKELLVNGRIPPVLVTAVSTILRQTVPALKPDIDRMAIYMGDYSWLGLGSDRRAELYRRTRDVDIIKKIPFRSTASAGSDETQSGKHNPSQVRRRCVRCCEIMCGAYPPRPQLSSRMMYKLGYVRYCICGGGWTLESDFHR
Length928
PositionTail
OrganismAspergillus oryzae (Yellow koji mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.08
Grand average of hydropathy-0.187
Instability index39.73
Isoelectric point6.46
Molecular weight102577.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12447
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     346.66|      92|      97|     286|     380|       1
---------------------------------------------------------------------------
  234-  325 (111.42/60.58)	........TQNGILIATYS........ACQKIYFYRVQINWtppqwdpsQLKQA...PnQFPV..PSFRfmhsKVEAPCIIP.SASRNGEATNDGMPSSTNPLYCLTRLDIVLA
  326-  422 (143.35/87.25)	AHDNSAGMTTNPWIIAVFSippHATPDHSQQQSPCSVIVRW........QLESA...P.QVLH..PKFDevnaKKNNAQIKPkSVLRRQE...DMYCDRYVTMIEQTEHGNVLA
  424-  501 (91.88/48.74)	TYDDSSVTFYDPKTMAVL....NGTDDTNTLTSLAHAGFQY........PPDSAgsfP.SRYRggTKFD...tSIAGLHISF.SPSGCNAVTLDG...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     412.58|     134|     173|     517|     666|       2
---------------------------------------------------------------------------
  517-  666 (206.31/178.33)	ENGLYDENKFS...AAVASLTL.........AF....CRGcgsefntddILLILKRQAS.P...DAQIsFINEVYRALGVNCNYTQENDKLMShQYLPKCLSVQAALGFIDKYKSrnfaSNVPWTILQLRHASVLYALFLQYLKGGVQAEPPDADAIRILLGNTKWaLDL
  682-  835 (206.27/137.23)	ESLLSDQEAFAqklKTISSLPLiillssmsrAFlrfiCRG.........LRGIQAGYATaPltgDAGV.YYAEIYRTLDTSPVRIDVYEKLLA.GVDSTVRHVYHGAGFGDNERP....GPEKELLVNGRIPPVLVTAVSTILRQTVPALKPDIDRMAIYMGDYSW.LGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.40|      36|     833|      50|      91|       3
---------------------------------------------------------------------------
   50-   91 (61.95/44.07)	CCQKIawskqgCIAYISQDTLRV....NLRHLECRPSDGKWVLSDD
  886-  925 (67.45/35.66)	CCEIM......CGAYPPRPQLSSrmmyKLGYVRYCICGGGWTLESD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.48|      16|      96|     111|     126|       4
---------------------------------------------------------------------------
  111-  126 (28.80/24.03)	WNEIGSELAVVDSSGR
  209-  224 (28.67/23.88)	WAEISAELKNASYSDR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12447 with Med16 domain of Kingdom Fungi
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