<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12446

Description "Mediator complex, subunit Med12"
SequenceMIPHSSAGVQSWGHPLRAVNNGSGHVDASQAVGPPDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDASPAPGSGGELRSTPGTGGSKPPSLSWRNRPVWSFQAMLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYIPESLGSNPTTSRASSPVKEVQTIPYRIETPSVAPVLKGEKVADFSPWIGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSLVTAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKALLDQCLNKGIPVNRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVRDWTASVQQFLEGVLGACGSAQWKMKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNIVPVWLLMLGIYWDNIMRYRKRGRRLAELLLVKLRQVRALILTVNTLLIRQQVTQPDKGGPLQPLVDRLSLYVRRLVLEHTSSVVLPGSWENHKELISSCLNLKDNVHKTIYQNLSERNSRLQLPKNHQDTAERSPQQRVIQLFDSIRSAHDISSASTACLKTIEDKAILISKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGIDVDSYILSFLADVRVTSALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTPQPVPSDLCLLKQLPANRLPEHVRNLRNTLLYRAGIPVMEEDSAIAELKISIAQRLPNIFGAEMDSAMPTESSQPHPTWAVKSEIGQWIRHGIAGHCRDSPRKLSGVSVAVDPGASALTPDEFYSVREILETFGDLSMLADILKQATRCDDDVVLASVADTVNCHFDCFCVIGATADLFRGLVESYARLKRLGNASLDLLFSLIELGLRIPSEFNTVALLRQDLTRLENKSALAAPSPLSDSIPLALSDVDPSFQEKLNQLLSSGGGMDESTMDTVFYSLMHILENSGSPAKLSANETARYLAYLRPFQPKHFDTMLIRWICGLLKSSTPSMSRILPPLIGVGCVTIHAFVFLVKKLLQSEKVAAVIPNLAGLRVDLLQLLVPLVSGKSKYADLVTYRFHVAQQEFFMKHPQETLDIICDAVALVNSETGSNPGQPDIAGCATELLDILLTQNPEVTVQYCLQGFIGKHSTSTTVLERALDNLLGFDSLAGPPTMSEAEKVVRMTDDFSLPFCQLKLQMLFNAESGRNVGNGIVDVMFKAAVEDTRSKGSNWVGFIRERAERALFSIPLFEEQLEAHGHPGTAKSLETAKLYLTIIEKLAYSVPEAGVQSVAPILVEKMDLLLHRLVIMQTNFNNVTMNRHGAATTQILQSRSNFERSLAFWFSAFLRMIVIHRSAFTMPSPAPRANGLQEQSRLLISILCISLARLPDSVIRLFPAADYFPHPIPSQGYRPCPGILLQTHALDVAASLIDTFPDEARQQCARFLKEKCPPFLQYQNDSRFIYLLGPMSDAAALNSLQAASLPSPAAGGSTPTPTPSSALPGAPSNPQPTAMTPAVTSASLSEGINCVASHLRLQYRGRAMGPYPVRPWELLEDAAPIVGVNDTAVNLKYFDARRVRA
Length1591
PositionKinase
OrganismAspergillus oryzae (Yellow koji mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.123
Instability index49.36
Isoelectric point8.77
Molecular weight175070.33
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12446
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     353.21|     106|     749|     694|     806|       1
---------------------------------------------------------------------------
   42-   76 (26.94/ 6.70)	.........................................................................................................LPTPVPQPQPRQ..PAVIDLTTSGGDAQELEPPPKRL.........
  694-  806 (170.25/117.86)	PQPVPSDlcLLKQLPANRLPEHVRNLRNTL................................LYRAGiPvMEEDSAIAELKisiAQRLPN.IFGAEM.....DSAMPTESSQPHPTWAVKSEIGQWIRHGIAGHCRDSPRKLSGVSVAVDP
 1415- 1556 (156.02/89.21)	PHPIPSQ..GYRPCPGILLQTHALDVAASLidtfpdearqqcarflkekcppflqyqndsrfIYLLG.P.MSDAAALNSLQ...AASLPSpAAGGSTptptpSSALPGAPSNPQPTAMTPAVTSASLSEGI..NCVASHLRLQYRGRAMGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.89|      22|     748|     299|     323|       2
---------------------------------------------------------------------------
  299-  323 (33.35/20.90)	WLRDLANPSVPlrKLSRTIPH..GIrG
 1013- 1036 (38.53/15.67)	WICGLLKSSTP..SMSRILPPliGV.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     235.83|      66|     311|     199|     279|       3
---------------------------------------------------------------------------
   88-  146 (88.12/39.82)	........DASPAPGSGGE..L.RSTPGTGGSKPPSLSWRN....RPvwSFQA.........MLSEVPGSNVMNEEDATAVAQ
  158-  196 (50.96/18.98)	VL.........PW.KYIPESLGSNPTTSRASSPVKEVQTIPYRIETP..SV................................
  199-  279 (96.75/67.85)	VLkgekvaDFSPWIGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARP..SLYAqlkhrsglqMLSSVFAAALEKRQNHSLVTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.32|      57|     259|     913|     970|       4
---------------------------------------------------------------------------
  913-  970 (92.26/59.73)	LRQDLTRLENKSALAAPSPLSDSIPLA.LSDvD...PSFQEKLNQLLS..SGGGMDESTMDTVF
 1169- 1231 (86.06/51.39)	LERALDNLLGFDSLAGPPTMSEAEKVVrMTD.DfslPFCQLKLQMLFNaeSGRNVGNGIVDVMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.32|      37|     234|     375|     426|       5
---------------------------------------------------------------------------
  375-  426 (61.83/74.88)	DWTASVQQF.LEGVL.GACGSAQWKMKmtyavsltarlfferLLDHDQYLGWFL
  611-  649 (61.49/43.10)	EWTATPFRYgLCRVYtGVRLLRKWKMS...............GIDVDSYILSFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.79|      19|     822|     491|     516|       6
---------------------------------------------------------------------------
  496-  516 (27.65/29.01)	PLqpLVDRLSLYVRRLVLEHT
 1306- 1324 (33.14/13.28)	PI..LVEKMDLLLHRLVIMQT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12446 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MIPHSSAGVQSWGHPLRAVNNGSGHVDASQAVGPPDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDASPAPGSGGELRSTPGTGGSKPPSLSWRNR
2) MLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYIPESLGSNPTTSRASSPVKEVQTIP
3) PSPAAGGSTPTPTPSSALPGAPSNPQPTAMTPAV
4) WIGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLY
1
126
1496
211
118
188
1529
248










Molecular Recognition Features






MoRF SequenceStartStop




1) ELEPPPKRLRLDLP
2) LPWKYIP
68
159
81
165