<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12444

Description Cwf15/Cwc15 cell cycle control protein
SequenceMTTAHRPTFDPAQGKEALRGPAYHQRLLPAHTHLKTRQLGQGGEGEAQQRDLRAELLQAEAAHFAKKRGIPVNEPTVESAAPKHQIEGGPSGSDSVGTEDEDPEAKRRRILEETRDIDADSDGSEDDSSEEESDDEEDEAAELMRELEKIKKERQEQKEKEERERAAEEEEKREYDIAKGNPLLNAQDFNLKRRWDDDVVFKNQARGTEDKRGKEFVNDLLRSDFHKRFMVESTSHTSTAVETYQLDVESTALVRAAEDILSLTRTMKETWLFGKLNTLGEDESDVKRREELERDADAIQRAIEEGGLLKPAK
Length313
PositionHead
OrganismAspergillus oryzae (Yellow koji mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.04
Grand average of hydropathy-1.174
Instability index61.01
Isoelectric point4.85
Molecular weight35561.50
Publications









Function






Annotated function

Involved in pre-mRNA splicing.



ECO:0000256	ARBA:ARBA00003777

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
spliceosomal complex	GO:0005681	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
mRNA splicing, via spliceosome	GO:0000398	IEA:InterPro
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12444
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.77|      35|      37|      65|     101|       1
---------------------------------------------------------------------------
   65-  101 (56.29/30.75)	AKKRGIpvNEPTVESAAPKHQIEGGPSGSDSVGTEDE
  105-  139 (58.48/26.96)	AKRRRI..LEETRDIDADSDGSEDDSSEEESDDEEDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.87|      11|      34|     181|     193|       2
---------------------------------------------------------------------------
  181-  193 (13.01/17.38)	NPLLNAqDFNlKR
  218-  228 (21.86/14.30)	NDLLRS.DFH.KR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12444 with Med22 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTTAHRPTFDPAQGKEALRGPAYHQRLLPAHTHLKTRQLGQGGEGEAQQRDLRAELLQAEAAHFAKKRGIPVNEPTVESAAPKHQIEGGPSGSDSVGTEDEDPEAKRRRILEETRDIDADSDGSEDDSSEEESDDEEDEAAELMRELEKIKKERQEQKEKEERERAAEEEEKREYDIAKGN
1
181










Molecular Recognition Features






MoRF SequenceStartStop




1) LRGPAYH
2) SVGTEDEDPEAKRRRILEETRDIDA
18
95
24
119