<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12439

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGSTASNPTPVSTSMITGVSLLSGAFMSAPTAVAVSPPHQTTNGHGPTPPTSQDDQELTKLLPDIPPTTFPFGELLDRTVQVSYLDLLNLAETLPSANNDERKKQLLHYCFAKRKLFTKLLVLLRANSKAKDILTCQKVHAFIDNQDNAFARAADDLFAIHNQMRAAKIANFDIQTAVDVLTTGAYQRLSKSLMPQLVPDAPLTSAEIDTTIERLGDLIRMRLMFEEVIPIPFRQNMKIEKGCVVFTVAGELTVTLTMVPDGSPQPWRVVDLQILSQSVPTGYGGSVPNLQTQQIQKFKETAQKHLMEDNSSYWPIVRLYEFIHKFNLTYQLHILSSQATYLSEDRWKDYLNVEKSESFLKLDFWRHLATQNVNREYYQLHISGTPPSSIYPPRSALSSGSPDDLQKEVCESLSRVVDDETKNNSLKISLFGIIGTTIRNIDIPDHIFLNTEALDVEELLLKLTDHQSRAMICAMRDELLSPDTPNNELLGPSHYLFTEDQVRMSPGVSGDINSTDMPSSFSPTKNVSPAASLLVMYRPSTWIRLSVNPRTGVFIANLADESGLGSLVTPQPSSSNGMNLGTAASRTISGSNGHSNDSISRNLKTVEDRINASVHNTKPAIMYLRRATTITQVETMALYLGLEVADFVQIGTESPLKHIQTDEVRMVHLRFPGKDHNILVIAAGSHEDMLEAHQGQSSLRKSAEPSMDYGDAEFHVWIMSLKIPQSRFKRPEFQVIPLFPADIPDMMDGTAKMDITMSDMVMDKDPFSKPLNVDDSHQAWSRIDLPVLSRIQAASSNLFAFAKLIEQLDGHGLTYQFLVRNGSGLIAKGQTHIGGVHISRLDPKVVISIHSFLELDVHQASKAKKIIDSNSLDPRSQLYSPKGTVYLYLEPTEKENSLLHTSGAISSTDLIDHHTHRVVAKMRIPSILLPSSNCPEKAGEYIEYQHETRTLVFKYPNLEGFADHFLSEFQAIGNIFRLLYQLSRHKSSLQRMDITVSFSDLHSLLVTWPTGSIMRTSWETKQDVRLGEGSNTKGTGDYLVTFERSDGSPDGNMPLSTLATVMLNKTREIFPLVQIINRVSRLVSSLEQIRERRHAFGQIGVSLEVLSLTHYRVVFPYFSKQCGLEFVIEHPSSFLMFDGSMLGYALEFGLGNIAGVGMDVYGDESQSTIHAERTLRPLPEFMDIPSMSIAGMEQMRPSRNGLLSSIRERVVEAGAALTSRASSIPPVPRNALVQSHQEANLADVGEGALVQLPHGILCTLSLVDIVMLSVEGYLDVMCSTDVIFPFLQMKPIMHTIHEEPHCRILYATESAKAALTCQANGRWGFVIAPTERTLDNKSSLTSLPDSKAWLDKLISEVNAIPIRQRNSLEWLKTVVTIAMIPEIPLRELMNVCRVAQALPQTRPMTLDWVLQSPADSPAHLPPPGDMSFIFDRDIDRIRLLYRFTDLSTNESVLIPIRYNFGAGLVSIWHNAARDVKHPDLTEFHPMDPKLEPLMKTLTKTNLTSLSILERTFVQASIKQIPPAMGGPGKLFAVIKHLTSRSITELRGGGDV
Length1552
PositionTail
OrganismBatrachochytrium salamandrivorans
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Chytridiomycetes> Rhizophydiales> Rhizophydiales incertae sedis> Batrachochytrium.
Aromaticity0.07
Grand average of hydropathy-0.174
Instability index44.12
Isoelectric point6.06
Molecular weight172663.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12439
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.49|      24|     134|      59|      96|       1
---------------------------------------------------------------------------
   65-   93 (34.17/43.05)	DIPPTTFPFGELLDrtvqVSYLdLLNLAE
  443-  466 (42.32/14.79)	DIPDHIFLNTEALD....VEEL.LLKLTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.20|      19|      20|    1345|    1364|       3
---------------------------------------------------------------------------
 1346- 1364 (32.97/20.02)	DSKAWLDKL..ISEVNAIPIR
 1367- 1387 (29.23/11.98)	NSLEWLKTVvtIAMIPEIPLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.57|      14|      15|     565|     578|       4
---------------------------------------------------------------------------
  565-  578 (25.44/16.14)	LGSLVTPQPSSSNG
  581-  594 (24.14/14.87)	LGTAASRTISGSNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.17|      15|      19|       1|      15|       5
---------------------------------------------------------------------------
    1-   15 (27.58/19.12)	MNGSTASNPTPVSTS
   23-   37 (25.58/17.11)	LSGAFMSAPTAVAVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.86|      12|      19|     706|     717|       6
---------------------------------------------------------------------------
  706-  717 (23.21/13.16)	PSMDYGDAEFHV
  725-  736 (22.65/12.67)	PQSRFKRPEFQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.24|      29|     782|     235|     265|       8
---------------------------------------------------------------------------
  235-  265 (42.40/37.95)	RQNMKIEKGCVVfTVAGELTVTLTMvPDGSP
 1022- 1050 (50.85/34.44)	KQDVRLGEGSNT.KGTGDYLVTFER.SDGSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     199.98|      52|     376|     467|     518|       9
---------------------------------------------------------------------------
  467-  510 (68.90/39.64)	..........HQ.SRAMICAMR.DE..LLSPD...TPNNELL...GP..SHYLFTEDQVRM....SP..GVS
  511-  544 (22.87/ 7.94)	GDINSTDM.................psSFSPTknvSPAASLLvmyRP..STWI...................
  859-  903 (40.94/20.39)	..........HQaSKAK.KIID.SN..SLDPR...S...QLY...SPkgTVYLYLEPTEKE....NSllHTS
  904-  960 (67.26/38.51)	GAISSTDLidHH.THRVVAKMRiPS..ILLPS...SNCPEKA...G....EYIEYQHETRTlvfkYP..NLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.85|      15|      16|     333|     348|      10
---------------------------------------------------------------------------
  333-  348 (23.73/20.14)	LHILSSQaTYLSEDRW
  352-  366 (26.12/16.82)	LNVEKSE.SFLKLDFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.04|      18|      21|    1086|    1105|      12
---------------------------------------------------------------------------
 1086- 1105 (27.33/27.76)	SLEQIRERRHAFG.QIGvsLE
 1108- 1126 (30.72/23.05)	SLTHYRVVFPYFSkQCG..LE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.44|      17|     781|     737|     754|      13
---------------------------------------------------------------------------
  737-  754 (28.97/23.19)	IPLFpADIPDM.MDGTAKM
 1179- 1196 (29.47/17.51)	LPEF.MDIPSMsIAGMEQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12439 with Med14 domain of Kingdom Fungi
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