<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12427

Description Uncharacterized protein
SequenceMEDSDLANILVVNNANRIEYVVLRQYPVKPSRCLYKPAGPWVASSSTPSPLSDPTAANNENNKNNINIINNNSSVNDTSPLHSWPTLQLTRMSHFRSSLLFKELERALDHGFAAMWLRKDRSRLTLDDLLDDAVVDMCDCELWIFSWSVRCPASSYIPESSLVHESTRGEFTSMDIYDTAGSATNNSTQEYALFLEGMQNLFERKLGYTRLGCYLLRDTTACDWPTRGIHAFRLFIYLAYGKLVIQPVQSIIQLEQLSFTWLRKHIEVTKEITVFVAPYGIRQFRVLDSTLANLGELDNIYDALDAAGGETETPPATHASDGSSAVAGSLALPANSLGLTAVQEKDAFLKAEESNHLAFPEPPPKQQLVLISPVPKPENYMDLDMSMNGLGDMGGLTDLTLGGGVTDEDFDFFETKKPSAAPTPRATTSFATPGWTSSEMTSSSSTYSGAMAAAGSFTSADLPSMSGTHSGSISAHGGVDLSGSALISSPAPALTPRASAHHNVFSPYAPFTTPRNDPMSPMYPTAHSVAAIPVGAESSPYASAMLHSVSPTESSGMVFGSPQFLHGDAATPHFAQSSPPGNVGMHMPVSPATHAAALTVLSPPGRPGLSAADRFVSMVSDPSSVDECTSDRDVNHNFASGAFEVDANLVQGFHSSYCENDSNIIDGKESDGHGDDNDNDNSNGMGELEKSPVVMSDAWLPFRIVFDLVFGHSGNSTDGSIKTSTKVVASGGWANPSSNCVLDVAAAVSDSANVTHSRYGNLHAKWCYIPKNRRIVKQQSSKKRQPGEIQTRFGMRRRHVAPTSAVVKLVQRTLELHGRDFHATASPFAASGGASANASGMDPVVAHCRRPIWRIGDFYNFTVLMPIETGAFVSQYEALWHTASGSDGLGDVQAVRSKFHPATTCVWCSGRSIPNDECECCMNVQSVHSGKLVGALAMCLPVPKFPSALFDLVRTILATGCGENDLLTVQKSDLVGPLSLLEYHDLQETDKSVAIYGGFQVRKKKRTSEPIVSVMPIPNIVFRHDGALLTANILSYRFWTKLRLEPYSGLKRLAYIALYAVSHDSSYSSTNTPEEGVIPDAADLENDVDTIQLRSNVCSWLLNFQQEWAVHRFGEINPLMDTADESVIPVHISNGEEFYQNLPTVLNLFSASLTEPVCKRVLEFLNDVSSPYLVPNTHNQLHSLPSNLSTYCTHLCLFVFIPPAFLRSSLLTDATPENYDRHVHLSAAVCNNLANLVSERTGANYSDIHARIVFKAVVAVHNCIYPPLVEHNDCHDVYNQCQWVLPPPAPDNGRDRPDVKSGNALRHGCIPAPTVVLDDKRVGKQAFLVLPSRNSSSVGSKHNTHLDPSCDEAGAKVSWTTNERLLIEPTRVAYVVYETCDEDSQYNRLIMRWSDHRGELSGAVLLLADDLESRADLFRRLIDVAQSSLGYGGFLFRLVVCKMGDIHRVEMQDWMRAISAWTEDASTKSVDTFETDGPSDVLPQGSNTEPAIAEQHSKLPHTRLGNGDTLETPIELDESSDTTETPKASEKPVPSYIISITIACLSTWGAIQCSRPLGAAPFGPLIQSSDDIWSEDTVSCTVFALPHHRPPLPTSSWSSTGPPPYLPLASGWLLKGTQSVRLSLMWHARCGSRSNSCYADTVVLDRWEMTNTPSPSGSSSSGYLAPLATHVTIVRDILKQLYALNCLYGLVNHK
Length1694
PositionKinase
OrganismBatrachochytrium salamandrivorans
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Chytridiomycetes> Rhizophydiales> Rhizophydiales incertae sedis> Batrachochytrium.
Aromaticity0.08
Grand average of hydropathy-0.215
Instability index50.55
Isoelectric point5.49
Molecular weight184572.40
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12427
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     381.69|      78|     838|     482|     559|       1
---------------------------------------------------------------------------
  314-  403 (89.03/42.62)	PPATHASDGSSAVAG.SLAlPANSLGLtaVQekdaflkaEESNHLA.FPEPPPK.......QQLVLISPVPKPenYMDLDMSMNG.LGDMGG...LT.....DLTLGG
  404-  477 (92.75/44.75)	GVTDEDFDFFETKKP.SAA.PTPRATT..SF........ATPGWTS.S...EMT.......SSSSTYSGAMAA..AGSFTSADLPSMSGTHSgsiSA.....HG....
  482-  532 (72.04/32.89)	.......................................SGSALIS.SPAPALT.......PRASAHHNVFSP..YAPFTTPRNDPMSPMYP...TA.....HSVAAI
  533-  571 (66.16/29.51)	PVGAESSPYASAMLH.SVS.PTESSGM..V.......................................................FGSPQF.....L.....HGDAAT
  572-  640 (61.70/26.96)	PHFAQSSPPGNVGMHmPVS.P.........................aTHAAALTvlsppgrPGLSAADR.........FVSMVSDPSSVDEC...TSdrdvnHNFAS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.79|      43|     837|     252|     304|       2
---------------------------------------------------------------------------
  205-  248 (75.27/51.27)	KLGYTRLGCYL..LRDTTACDWPtRGIHAFRLF.IYLA.YGKL..VIQPV
  256-  304 (55.51/53.33)	QLSFTWLRKHIevTKEITVFVAP.YGIRQFRVLdSTLAnLGELdnIYDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.23|      38|     135|    1078|    1116|       3
---------------------------------------------------------------------------
 1078- 1116 (63.58/55.03)	IPDAADLENDVDtIQLRSNVCSWLLNFQQEWAVHRFGEI
 1211- 1248 (64.65/50.39)	LTDATPENYDRH.VHLSAAVCNNLANLVSERTGANYSDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     380.01|     118|    1240|      26|     148|       6
---------------------------------------------------------------------------
   26-  148 (198.55/131.87)	YP..VKPSRC..LYKPAgPWVASSSTPSPLSD.PTAANNENNKNniNIINNNSSVNDTSPLHSWPTLQL.TRMSHFRSSLLFKELERALDH.GFAAMWLRKDrsRLTLDDL.LDDAVVDMCDCELW....IFSWS
 1265- 1394 (181.46/106.36)	YPplVEHNDChdVYNQC.QWVLPPPAPDNGRDrPDVKSGNALRH..GCIPAPTVVLDDKRVGKQAFLVLpSRNSSSVGSKHNTHLDPSCDEaGAKVSWTTNE..RLLIEPTrVAYVVYETCDEDSQynrlIMRWS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12427 with Med13 domain of Kingdom Fungi
Unable to open file!