<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12412

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIVSMDRNGAQGASLGKLDDRALAASAAAHSKLNGDVPLPHVDRPSDMNGKAATNGAASLSQSPAADLSQLPPELTHFTEFYMPFGKLVERVAQETNVTLSELLDKMSNLQISSAPTMNGINGHATNGATPQSRDNEEKKTLMLNWAWGEREKFIKLLVLSKWSRSCEDVSKMIDLNAWLTEQMNHYEEAPKWIGQLKLNMDPAKAPNPDLKTALEVLSTGKAPWMPDLGYIPAEPLTPQQMLKTVTNLNAILAIRINLHEELPRHMKDWSIASGRATFRVPSEFELDVSIADEDPTSSFFIVDVRFLFTPKPEVPDAWFREWVEPQANIVLANSGLSGIYDWLHGFVLTHKLTTLKMQAYELAQTSWANSIHVQQVHRSLTVQYWTGTSGAKSWIEIGISSGKSKDGKVSWRGPSPPQLSLRWTRKGVPVENIPITIDWTELSLENILKAIVALHISFILESIRNQLSTLSEKRSGLLMENVTSTAEPADCFLHLQPGRMSKATEVRIDPVSGGLSLRPATPLSLHLERDVRDIATDAASKIETLICNDLRNRVDKEANNVGWIKPLHINIRPEVTSASVQQKVVAQSFYRCQNWQSRWVLGLTVNLDGENWWLVELITPVLFIKSGPLLGEKEGHNSWAGEILRLHHKGLDTKSGCIVHAVRGQMSQGHVDFNLVSSQAGDVSFNSDGTFEVRLRTPFGEPFLEKIINRLKRIERLGRIVDVAKDQKLHCSQISLSRVVFRYCGNYKADIRFPEGSPVQLCISPDNPHRRVAAFLKNVLNDRDSSKSFPFFMKILSQTLPLLRGFESMESSAPAPASLPQPYINPRSLDWYRICYENPLTTFDIRLRTRHDTMEWHIHDSTNQQVHPRSPDFAAAVKDLLKQSGDKWIGVRTGIVAKIDGVEDALKKLDEVVKKHQKPVLERPVGGVASAQQAPGPTQQGKPQPQGQAKLSNQQAAIKPDPEVIMLD
Length971
PositionTail
OrganismDiplodia seriata
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Botryosphaeriales> Botryosphaeriaceae> Diplodia.
Aromaticity0.07
Grand average of hydropathy-0.342
Instability index42.66
Isoelectric point7.68
Molecular weight108267.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12412
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     208.27|      46|      70|      17|      65|       1
---------------------------------------------------------------------------
   17-   62 (72.90/38.39)	LGKLDDRALAASAAAHSKLNGDVPLPHVDRPSDMNG..KAATNGAASL
   87-  133 (62.31/30.46)	FGKLVERVAQETNVTLSELLDKMSNLQISSAPTMNGinGHATNGATP.
  909-  954 (73.06/38.49)	LKKLDEVVKKHQKPVLERPVGGVASAQQAPGPTQQG..KPQPQGQAKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.15|      26|     489|     344|     405|       2
---------------------------------------------------------------------------
  377-  405 (42.36/92.32)	QQVH.RS....LTVQYWTGTSGAKsWIeiGISSG
  867-  897 (38.79/ 9.73)	QQVHpRSpdfaAAVKDLLKQSGDK.WI..GVRTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.86|      21|      29|     195|     215|       6
---------------------------------------------------------------------------
  195-  215 (38.45/24.50)	WIGQLKLNMDPAKAPNPDLKT
  227-  247 (40.41/26.15)	WMPDLGYIPAEPLTPQQMLKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.53|      19|     391|     432|     451|       7
---------------------------------------------------------------------------
  432-  451 (30.57/22.87)	PVENiPITIDWTELSLENIL
  825-  843 (39.96/25.64)	PYIN.PRSLDWYRICYENPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.53|      12|     163|     494|     505|      10
---------------------------------------------------------------------------
  494-  505 (24.37/17.00)	CFLHLQPGRMSK
  660-  671 (23.15/15.78)	CIVHAVRGQMSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.91|      25|     460|     274|     298|      12
---------------------------------------------------------------------------
  274-  298 (40.79/27.16)	IASGRATFRVPSEFELDVSIADEDP
  737-  761 (44.12/30.01)	ISLSRVVFRYCGNYKADIRFPEGSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.11|      18|      70|     177|     194|      14
---------------------------------------------------------------------------
  177-  194 (34.93/26.91)	DLNAWLTEQMNHYEEAPK
  250-  267 (31.18/23.16)	NLNAILAIRINLHEELPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12412 with Med14 domain of Kingdom Fungi
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