<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12395

Description Mediator of RNA polymerase II transcription subunit 9
SequencePTSLISPIPPIFHKNPSFSNSNNFLFNISSSSSSSKHFTTNNSNFSPKFNPNSNSSSNSSPLNFNTNNPPLKSSPNNNPPPNFNSNCNPNISPSSSNSNIIFQQQQQQQRLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHQHQSLASHFHLLHLVEKLADAIENGTRDQQSDALVNDLNNHFEKCQQLLNSISGSLSSKAMTVEGQKKKLEEHEQLLSHRRELIGKYKNSVEELVKGEP
Length258
PositionMiddle
OrganismCucumis melo (Muskmelon)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Cucurbitales> Cucurbitaceae> Benincaseae> Cucumis.
Aromaticity0.05
Grand average of hydropathy-1.342
Instability index80.51
Isoelectric point8.68
Molecular weight29540.65
Publications
PubMed=22753475

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364145
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP12395
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.99|      15|      15|     113|     127|       1
---------------------------------------------------------------------------
  103-  119 (30.14/ 6.36)	QQQQQQQRllQQQQQQQ
  120-  135 (31.23/ 6.80)	QQQQQQQQ.qQQQQQQQ
  136-  150 (35.63/ 8.58)	QQQQQQQQ..QQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.60|      18|      18|      61|      78|       2
---------------------------------------------------------------------------
   16-   33 (28.35/ 9.76)	PSFSNSN.NF...LF..NISSSSS
   35-   54 (26.80/ 8.86)	SKHFTTN.NS...NFspKFNPNSN
   61-   78 (36.93/14.73)	PLNFNTN.NP...PL..KSSPNNN
   80-   99 (25.52/ 8.11)	PPNFNSNcNPnisP....SSSNSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.70|      19|      26|     190|     208|       3
---------------------------------------------------------------------------
  190-  208 (33.84/21.46)	SDAL.VNDLNNHFEKCQQLL
  217-  236 (24.86/14.03)	SKAMtVEGQKKKLEEHEQLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12395 with Med9 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SSSSSSSKHFTTNNSNFSPKFNPNSNSSSNSSPLNFNTNNPPLKSSPNNNPPPNFNSNCNPNISPSSSNSNIIFQQQQQQQRLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHQHQSLASHFHLLHLVEKLADAIENGTRDQQSDALVNDLNN
29
199










Molecular Recognition Features






MoRF SequenceStartStop




NANANA