<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12390

Description LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHPASCTSAVNNSAIGGPSARDTVRADSSSLPGNFPLNSRRPAPLTAYKLKCEKESLNNRLGPPDFHPQTSSCPEENLTREYVQSGYRETVEGLEESREILLTQVQAFSKHLVIKCKDATRKRLRAINDSRAQKRKAGQVYGVPLSVSLLTKPGIFPEQRPCGEDFRKKWIEGLSQQHKRLRSLADNVPHGYRKRALFEVLIRNNVPLLRATWFIKITYLNQVRPNSASISCGAFDKAQLSRTEFWTKDVVDYLECLVEEFISRSNSHLTPPNKDRSPQMFSVGFSHTKGDPPAVFDGEEPSLHFKWWYVVRLLLWHQAEGLLLPSLIVDWVLGQLEENDVLEILELLLPIIYGVLDTIVLSQTYVRTLVRISVRFIRDSFPGGSDLVDNSRRVYTTSALVEMLRYLVLAVPDTFVALDCFPFPRCVVSHTVNDGSFGSKVPEDVTKLRYTSAEVASPLRSKSIDFQYQSSAFDNVVSSIRKCADNLAKVVNPKFPVCSVAKAVHALDKSLLHGDIGVAYKYLFEDCCNGSINEGWFEEVSPCLRMSLKWIQTVNVAFACSVFFLCEWATCEYRDFWSAAPRELKFTGGKDFSQVYIATRLLKMKARDLQSVSGLKFETSSGLNSTKGSSHQNSLLGRKPVGNLFEPKSRLKKLGGNGSLDLFESPGPLHDILVCWIDQHEVQKGEGFKRVQLLIVELVRAGIFYPHSYVRQLIVSGIMDSNGPAVDSDKRRRHQQILKHLPGSFVCATLDDGKIAQGAQLVEVINVYSKERRLVLHGLVYEQLSDIGSANIPSNRKRKMCPTSDKVSSSVTSVNQLKSIPPFSNTGSTKRLKSEVDIEALKEAISLLLRFPNSSSLPTDTGLDDPSGSGKKSFASVYAKIDIAEATHGCEDCRRAKKQKVSDERNLYLHASSPIPSDDEDMWWVKKGPKSSETLKVDPPVKTTKPVSKGRRKTQSLAHLAASRIEGSQGASTSHVCDNRVACPHHRSGIEGDATRAIDNSKISGDIASIGKSLRKLRLTEKRAISSWLMTAVKQFIEETEKTISKAGQFGRSLTTVDDRITIRWKLAEDQLSSILYLSDVCNDFVSGVKFLLWLLPKVLISSNSTMNSRRSILLLPKNVENQVFEVGEAYLLSSLRRYENILVAADLISEALSSVTHRAMAIMASNGRISGSAAVVYARYLLKKYSSMPSVVEWEKTFKATYDQRLIAELDPGSTLDGELGLPLGVPAGVEDLDDFFRQKIGGGRLSRVGMNMRELVGRQVDDAFHYLLGKDRKVFSGTAPKVLATDKSDEGYQIAQKIIIGLMECIRHTGGAAQEGDPSLVSSAVSAIVGNLSTTVSKISDSIVGGSSNIPSASGSLDFAKRILSIHVTCLCLLKEALGERQSRVFEIALATEAFSALAGVYPSGKTSRSQFQSLADSHDSNTHVFGDNSKVIGKATKVAAAISALVIGAVIQGVCSLERLVALFRLKEGLDFIQFVRTTRSNANGNTRTIGMHKIESSIEDYVHWFRLLVGNCRTVFDGLIVELLGEPSIVALFRMQRLLPLSLVLPPAYSIFTFVVWRPFILNSAVTVREDVNQLCQSLTIAIGDIVRHLPFRDICLRDSQGFYNHLMMDTSDVEFAAILELNGSDIPTKSMAFVPLRARLFLNAIIDCKLPSSMYNQDDGTRISGVGDGKGQYPERKMKLLDRLVHVLDTLQPAKFHWQWVELRLLLNEQAIIEKLETRDMSLADAVRLASPSPERVAASDNEKNFIEIILTRLLVRPDAASLFSDVIHLFGRSLEDSMLLQAKWFLGGQDVLFGRKSIRQRLTNIAESKGLSTKTMFWKPWGWCISGSDTSYLEEGEVVEEGTDSRKYNQKSVQMLDNEVLHSGQQYVTERALIELVLPCIDQSSEESRNTFANDLIKQLNNIEQQINAVTSGTSKQTGSVPSGIEGPTSKGSSRKMKGGSPGMARRSTGSTDSPLPSPAALRASMSLRLQLILRLLPVILEDREPSGRNMRHMLASVILRLLGNRMVHEDANLTFCPTHSSMVKKEVESPSEASFAAFADLPGESIFGRMLLILHGLLSSCQPSWLGLKNAAKSTNETSKESSSLVRELAESLQNELHCMQLPDMIRWRIQAAMPIPLPPGRCFLSYQPPTIPHSALSSFQSSISTPGHGSGNSSMPQGSKISSPRVVPSAPGKSKPLPPQQDHDTEIDPWLLLEDGAGSSQSSSNSAVIGSGEHANFRASNCLKGAVRVRRTDLTYIGAMDDDS
Length2255
PositionKinase
OrganismCucumis melo (Muskmelon)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Cucurbitales> Cucurbitaceae> Benincaseae> Cucumis.
Aromaticity0.07
Grand average of hydropathy-0.206
Instability index46.75
Isoelectric point8.79
Molecular weight249147.13
Publications
PubMed=22753475

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12390
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.42|       9|     116|      35|      45|       1
---------------------------------------------------------------------------
   35-   45 (15.92/13.53)	PGNFPlnSRRP
  156-  164 (20.51/10.27)	PGIFP..EQRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     480.03|     162|     697|    1053|    1258|       5
---------------------------------------------------------------------------
 1053- 1258 (231.45/244.21)	FGRSLttvDDRITI..RWKL.AEDQL...SSI.LYLSDVCNDFVSGVKFLLWLLPKVLISSNSTmnsrrSILllpknVENQVFEVG...EAYLLSSLRRYENilvaaDLISEALSSVTHRAmaimasngrisgsaavvyaryLLKKYssMPSVVEWEKTFKATYDQRLIAELDP.....GSTLDGELGLPLGVPAGVE.DLDDFFRQKIGGGrlsRVGMNMR
 1779- 1956 (248.58/168.12)	FGRSL...EDSMLLqaKWFLgGQDVLfgrKSIrQRLTNIAESKGLSTKTMFWKPWGWCISGSDT.....SYL.....EEGEVVEEGtdsRKYNQKSVQMLDN.....EVLHSGQQYVTERA.....................LIELV..LPCIDQSSEESRNTFANDLIKQLNNieqqiNAVTSGTSKQTGSVPSGIEgPTSKGSSRKMKGG...SPGMARR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.61|      52|     121|     608|     675|       6
---------------------------------------------------------------------------
  615-  675 (66.33/72.66)	VSGLKFETSSGLNSTKGSSHQnSLLGRKP.....................VGNLFEPKSRLkKLGGngsLdLFESpgpLHDI
  718-  790 (79.27/40.53)	VSGIMDSNGPAVDSDKRRRHQ.QILKHLPgsfvcatlddgkiaqgaqlveVINVYSKERRL.VLHG...L.VYEQ...LSDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.80|      14|     223|    1740|    1763|       7
---------------------------------------------------------------------------
 1716- 1729 (23.71/26.04)	NEQAIIEKLETRDM
 1750- 1763 (23.09/ 6.37)	NEKNFIEIILTRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.90|      36|      59|    2127|    2162|      11
---------------------------------------------------------------------------
 2127- 2162 (69.57/37.83)	PLPPGRCF.LSYQPPTIPHSALSSFQSSISTPGHGSG
 2187- 2223 (61.34/32.47)	PLPPQQDHdTEIDPWLLLEDGAGSSQSSSNSAVIGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.77|      38|     480|     486|     526|      12
---------------------------------------------------------------------------
  486-  526 (59.29/54.59)	CaDNlaKVVNPKFPVCSVAKAVHALDKSLLHGDIGVAYKYL
  980- 1017 (68.48/50.65)	C.DN..RVACPHHRSGIEGDATRAIDNSKISGDIASIGKSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.61|      19|      27|    1465|    1483|      18
---------------------------------------------------------------------------
 1465- 1483 (30.27/23.23)	RLVALFRLKEGL.DFIQFVR
 1494- 1513 (30.33/23.30)	RTIGMHKIESSIeDYVHWFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.45|      42|      62|    1997|    2039|      19
---------------------------------------------------------------------------
 1997- 2039 (69.56/52.16)	GRNM..RH.MLASVILRLLGNRMVHEDANLTfCPTHSSMVKKEVES
 2058- 2102 (61.89/40.70)	GRMLliLHgLLSSCQPSWLGLKNAAKSTNET.SKESSSLVRELAES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12390 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALSSFQSSISTPGHGSGNSSMPQGSKISSPRVVPSAPGKSKPLPPQQDHDTEIDPWLLLEDG
2) CTSAVNNSAIGGPSARDTVRADSSSLPGNFPLNSR
3) DEDMWWVKKGPKSSETLKVDPPVKTTKPVSKGRRKTQSLAHLAASRI
4) INAVTSGTSKQTGSVPSGIEGPTSKGSSRKMKGGSPGMARRSTGSTDSPLPSPA
2146
9
922
1916
2207
43
968
1969










Molecular Recognition Features






MoRF SequenceStartStop




1) MWWVK
925
929