<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12388

Description mediator of RNA polymerase II transcription subunit 23 isoform X2
SequenceMCTLSCRNKAQKRVLAINRELPPRNEQFLLDFEQIQNQFSDHDQLRAVTESVLISLVVQCSGHVPRAEFLLFALRSLCSISYINWDTFLPSLLSSISSAEVSMGQGSQAAPTVSTTNLSQSGVLPSSNPVPNSSTFQSSNPASPLPSVHGISSPAQSSIDPSSCTALSPIKSSDLSGTGLPSAVRVNSFLRNNAISSLRQLCCKIILSGLKFDLKPVTHADIFSHMLNWMVNWDQRQQGMEESENMKSWRPDKALIEWLHSCLDVVWLLVEENKCRVPFYELLRSGLQFIDNIPDDEALFTLILEIHRRRDMMAMHMQMLDQHLHSPTFGTQRIFSQTMQNISGEAVASLRYSPITYPSVLGEPLHGEDIASAIQRGTRDWERAMRCIRHALRTTPSPDWWKRVLLVAPGYRSSAQGLSPGAVFTSEMICEATIDRIFELLKLTNSEIHCWQEWLVFSDIFFFLMKSGCIDFADFVAKLFSRVTEGGQHVLRTNHVTWLFAQIIRVELVMSALNSDARKVETTRKIISFHREDKNADPNNPQSILLDFISSCQNLRIWSLNTTTREYLNSEQLQKGKQIDEWWRQASKGDRMVDYMNMDDKSIGMFWVVSYTMAQPACETVMNWLTSAGAPELSSAQNLQTNERIMVMREVSPLPMSLLSGFSMNLCSKLAYQMEESLFSGQAVPSIALAETYTRLLLLAPHSLFRSHFNHLAQRNPSLLSRPGVTLLVLEILNYRLLPLYRYQGKSKALMYDVTKIISALKGKRGDHRVFRLAENLCMNLIFSLRDFFFVKREGKGPTEFTETLNRLAVVTLAILIKTRGIADADHLLYLQTMLEQTMATSQHTWSEKTLRYFPPVLREVLIGRIDKRGVAIQAWQQAETTVINQCNQLLSPSADPTYVMTYISHSFPQHKQYLCAGAWILMQGHPESINCTTLARVLREFSPEEVTANIYTMVDVLLHHIQIEPQHGHSTQDILLKVCANLSFFVWTQELLPLDILLLAFIDRDDDPNALRIVISLLDRQELQQRVKLYCISRGSPEHWLHSVVFKRNELQKALGNHLSWKDRYPVFFDDIAARLLPVIPLIVYRLIENDAVDQADRVLAMYSPFLAYHPLRFTFVRDILAYFYSHLPNKLIVRILYVLDISKIPFSESFPQHISSAGPVMCPPMDYFATLLLGLVNNVIPSLQTSKSGTAGDASSSSMRPSHNKAPGTNPPVATSAPESQKAFYQIQDPGTYTQLVLETAVIELLSLPVSAGQIVSSLVQIVVNIQPTLIQSSNNLHVAPSSMGQGSALPTSPSGGSTDSLNAGRSNTSVSGINTPNFVSRSGYTCQQLSSLMIQACGLLLAQLPQEFHGQLYLEASRIIKETWWLSDATRSLGELNSAVGYSLMDPTWAAQDNTSTAIGNTVALLHSLFSNLPQEWLEGAHVIIKHLRPVTSVAMLRIVFRIIGPLLPKLANAHSLFCKTLSSLLSVMVDVFGKNSQTSIPVEAAEIADLIDFLHHVVHYEGQGGPVVASSKPRQEVLAIIGRALENLRPDVQHLLSHLKPDTTSSIYAATHPKLVQNPA
Length1564
PositionTail
OrganismCucumis melo (Muskmelon)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Cucurbitales> Cucurbitaceae> Benincaseae> Cucumis.
Aromaticity0.08
Grand average of hydropathy-0.036
Instability index45.29
Isoelectric point6.81
Molecular weight175142.43
Publications
PubMed=22753475

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12388
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.62|      18|     123|      69|     101|       1
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   71-   88 (35.32/36.14)	LFALRSLCSISYINWDTF
 1304- 1321 (33.30/ 6.36)	LNAGRSNTSVSGINTPNF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.78|      18|     324|     343|     361|       2
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  343-  361 (27.88/24.93)	SGEAVASLRYSPiTYPSVL
  680-  697 (30.90/21.92)	SGQAVPSIALAE.TYTRLL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     135.79|      65|     324|    1041|    1117|       3
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  258-  285 (22.17/ 7.21)	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................WLHScldVVWLLVEENK......C...RVP.FYELLRS
  288-  329 (53.49/27.36)	QFIDNIPddEALFTLILE..IHRRRDMMAMHMQMLDQHLHSPTF.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1041- 1075 ( 9.75/24.37)	............................................gtqrifsqtmqnisgeavaslryspitypsvlgeplhgediasaiqrgtrdweramrcirhalrttpspdwwkrvllvapgyrssaqglspgavftsemiceatidrifellkltnseihcwqewlvfsdiffflmksgcidfadfvaklfsrvteggqhvlrtnhvtwlfaqiirvelvmsalnsdarkvettrkiisfhredknadpnnpqsilldfisscqnlriwslntttreylnseqlqkgkqidewwrqaskgdrmvdymnmddksigmfwvvsytmaqpacetvmnwltsagapelssaqnlqtnerimvmrevsplpmsllsgfsmnlcsklayqmeeslfsgqavpsialaetytrllllaphslfrshfnhlaqrnpsllsrpgvtllvleilnyrllplyryqgkskalmydvtkiisalkgkrgdhrvfrlaenlcmnlifslrdfffvkregkgpteftetlnrlavvtlailiktrgiadadhllylqtmleqtmatsqhtwsektlryfppvlrevligridkrgvaiqawqqaettvinqcnqllspsadptyvmtyishsfpqhkqylcagawilmqghpesincttlarvlrefspeevtaniytmvdvllhhiqiepqhghstqdillkvcanlsffvwtqellpldilllafidrdddpnalrivislldrqelqqrvklycisrgspehWLHS...VVFKRNELQKalgnhlSwkdRYPvFFDDIAA
 1076- 1117 (50.38/31.10)	RLLPVIP..LIVYRLIENdaVDQADRVLAMYSPFLAYHPLRFTF.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.81|      18|     181|     966|     986|       4
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  966-  986 (29.91/26.45)	PQHGHSTQDILlkvCANLSFF
 1153- 1170 (37.89/24.86)	PQHISSAGPVM...CPPMDYF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.61|      33|    1180|      90|     122|       6
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   90-  122 (57.20/35.26)	PSLLSSISSAEV...SMGQGS.QAAPTVSTTNLSQSG
  146-  179 (49.81/29.66)	PSVHGISSPAQS...SIDPSScTALSPIKSSDLSGTG
 1270- 1298 (43.60/24.97)	PTLIQSSNNLHVapsSMGQGS..ALPT......SPSG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.07|      54|     965|     400|     455|       7
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  400-  455 (90.92/77.92)	WWKRVLLVAPGYRSSAQGLS.PGAVFTSEMICEATIDRIFELLKLTNSEIHcwQEWL
 1367- 1421 (92.16/69.00)	WWLSDATRSLGELNSAVGYSlMDPTWAAQDNTSTAIGNTVALLHSLFSNLP..QEWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.58|      26|     514|      12|      37|      13
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   12-   37 (46.62/28.19)	KRVLAINRE...LPPRNEQ.FLLDF.EQIQN
  524-  554 (34.96/19.27)	RKIISFHREdknADPNNPQsILLDFiSSCQN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.76|      16|     161|     851|     870|      15
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  851-  866 (29.85/24.62)	LRYFPPVLREVLIGRI
 1122- 1137 (29.91/13.30)	LAYFYSHLPNKLIVRI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.97|      22|      43|     868|     890|      17
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  868-  890 (35.11/29.65)	KRGVAIQAW..QQAETTVINqCNQL
  912-  935 (38.86/27.39)	KQYLCAGAWilMQGHPESIN.CTTL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12388 with Med23 domain of Kingdom Viridiplantae
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