<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12368

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVSRTAEESYATLNELVEKCKSSDLSDSEKKIGILKYIVKTQQRMLRLNVLSKWCQQVPLIQYCQQLASTLSSHETCFTQAADSLFFMHEGLQQARAPIYDVPSAVEVLLTGSYERLPKCIEDVGLQSILNANQQKPALKKLDALVRSKLLEVSLPKDITEVKVSDGTVLLRVDGEFKVLVTLGYRGHLSMWRILHMELLVGERSGPMKLDDFRRHALGDDLERRMAAADNPFMTLYSILHELCVALVMDTVIRQVQTLRHGRWKDAIRFELISDGSTGQGGSSGSAQISQDGESDSASLRTPGLKILYWLDLDKNSSTSEIGTCPFIKIEPGLDLRIKCLHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLRVICCNRYTRLLEIYKELEKNGQICRVPGDVQLQCHVEDMLADSRKKDNKFDSREYQGQEVLRVRAFGSSFFTLAINIRNGHFILHSSKNIISSLVVVECEEALNQRSMSAADAFISLRSKSILHLFACIGRFLGLEVFEHGSAAVKVPKSISCGINLLLMGFPECGSSYFLLMELDKDFKPVFKLLESQSDTPEKAQSLVDLSNVVRVKTVDIGRMQICEDELNLSLLNSKKLLSILPSDGGSHQTSENSLLADFSLEGSIVSSSAPSTFCSIVDEIFELEKGSSVPSFSGQIPPSTFGASPASHLGSGVANYQCLKVGTLSPKWDRGTGNYSSSMYKGVIQSGSAGSLATAPGRSQTVKKLTASKSEQDLTSLRSPHSAGAGSYTSLDEDQLTVSTNRSARLLSPPQRACPPASALSGKASAPRNSAAGTVPVGFRTSESNSLVLSPGSQAIDSATCPQSEQDAASRYNILPRKRTLSDLLDSLPSLQAMESNEGSYKRRKLVESAGTHLPKSLMLISSDISGKAEEYSYGSLIAEANKGNAPSSIYVSSLLHVVRHCSLCIKHARLTSQMEALEIPYVEEVGLRSASSNLWFRVPFARDDAWQHICLRLGXPGLNGIDSNFTGSQQAVGLTNSNSLNAGSQLPAANTNRTNLSNSTGLVRPANAVTGFNRTANGLPAASNLAVVNAGMPLRRPPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVISVKRFHQSQQQQQQNPGSAQEELTQAEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQVQGGDMVPTQKSRIELCLENHAGCSIDGSSENTSASKSNIHYDRGGGGGCVEQHA
Length1321
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.06
Grand average of hydropathy-0.146
Instability index48.55
Isoelectric point6.73
Molecular weight143535.87
Publications
PubMed=24807620

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP12368
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     331.72|     107|     163|     574|     685|       1
---------------------------------------------------------------------------
  574-  685 (162.85/107.33)	QSDTPEK...AQSLVDLSNVVRVKTVDIGRM.QICEDELNLSLLNSKKLLSilPSDGGSHQTSenSLLADFSLEGSIVSSSAPSTFCSIVDEIFELEKGSSVPSfSGQIPPSTFGA
  740-  850 (168.87/96.77)	RSQTVKKltaSKSEQDLTSLRSPHSAGAGSYtSLDEDQLTVSTNRSARLLS..PPQRACPPAS..ALSGKASAPRNSAAGTVPVGFRTSESNSLVLSPGSQAID.SATCPQSEQDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.76|      43|     215|     209|     254|       3
---------------------------------------------------------------------------
  209-  254 (69.04/60.01)	HME.LLVGERSGPMKLDDfrRHALGDDLeRRMAAADNPFMTL.......YSILH
  420-  470 (65.72/45.15)	HVEdMLADSRKKDNKFDS..REYQGQEV.LRVRAFGSSFFTLainirngHFILH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.31|      19|      22|    1110|    1130|       4
---------------------------------------------------------------------------
 1106- 1125 (33.23/23.64)	Y.GGGWV....PLVaLKKVLRGILK
 1126- 1149 (26.09/17.79)	YlGVLWLfaqlPDL.LKEILGSILK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12368 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGSLATAPGRSQTVKKLTASKSEQDLTSLRSPHSAGAGSYTSLDEDQLTVSTNRSARLLSPPQRACPPASALSGKASAPRNSAAGTVPV
731
819










Molecular Recognition Features






MoRF SequenceStartStop




NANANA