<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12365

Description mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHGGSCTSAVNNSTIGGSSARDSSRVESASLPPNFSRRPLQLTPYKLKCDKEHLNSRLGPPDFLPQTPNCPEETLTKEYVQSGYRETVEGLEEAREISLSQVQAFTKPVIFKCKEAIRKCHRAINESRAQKRKAGQVYGVPLEGLQLTKPGTFPDQRSCGEEFRKKWIEGLSQQHKRLRSLADHVPHGYRRKSLFEVLIRNNVPLLRATWFVKVTYLNQVRPGSSSMSSGVPDKTHISRSEQWTKDVIDYLQYLLDEFISRNSVHSALHIRDRSPQMGYAGSIQLKSDPTLGTIDCEEPSLHFKWWYVVRILQWHQREGLLIPSLIIDWVLNQLQEKELLGVLQLLLPVIYGFIDTVVLSQSYVRTLVGIAIRFIQEPSPGGSDLVDNSRRAYTMAALVEMLRYLMLAVPDTFVALDCFPMPPCVMNNVVTDGSLYSKVTEDARKVKNGPFEVAYFLRDKGPEVRSDSYSISRVVSSIQKRAQNLAMAARPGHPGQNVAKALHALDKALAHGDLREAYKFLLENVHDSSIDDCWFAEVSSCLRSSLKYIRSVTLSSICSVFFICEWATCDFRDFRYAPPRGIKFTGRKDFSAIYIAVRLLKLKMREAGLSSRLREHKIVKNDYLRTDPGQLTNYSGRSPGSGASEPLCYKRRASGKCGDFLGMFDSPCPLHDILVCWIDQHEVQNTEGFKRLQLLIIELIRAGIFYPQAYVRQLIVSGLMDGNGPISDPMKQKRHCKILKHLPGQYVQDALEEARIAESHVLSEVMNVYCNERKLVLHGKIDPYSTTCGTSYHKHKPRPNSGESLSAPSVDQLRSSESGSFRLSKDAGRGAELEELKGSITTLLQLPSSSSTDTGVDESQVSFKKAVVSGSNGMDNSEGTPGCEECRRAKKLKISEEKSSYSQIYPLNPSDDEETWWMRKGQKSIESFRAEPPPKPAKSASKGRQKVVRKTQSLAQLAAARIEGSQGASTSHVCDSKISCPHHRSGIEGIAPKSADGTRMPNGDVVSIGKVLKRLRFMEKRTITVWLIGIVKQLVEESEKTVTKVGQYGRPFSAADERGCVRWKLGEDELSAVLYLIDSCDELVLAARFLLWLLPKVLGSCSATVHGSRNILTIPKNAENNVCEVGEAYLLSSMRRYESIIVAADLIPETLSVVMRRAQAILTSNGRVSGSPAVIYARXAVIYARYLLKKYGSVGSVTEWEKTVKSTFDKRLASEVESGRLLDGEFGFPLGVPVGVQDPDDYFRQKITGVRVSRVGLSMRDIVQKKVDEAVNYFYGKDRKLFGPNSGKIPGFQKWEDVYQIGQQIVMGLMDCMRQTGGAAQEGDPTLVSSAISAIVCNIGQVIAKIPDLSASNNHLSFSSTSASLHFARCILRIHVICLCILKEALGERQSRVFEVALATETSSALAPVFAPGKAPCSQFQLSPELNDSNPSSDILNNSSRVALGRAAKISAAVSALVIGAILQGVASLERMVSLFRLKDGLDVVHFVRSMRSNSNGNARSVGTLKADSLAEVSVHWFRVLVGNCRTVSDGFIVDLLGEASILALCRMQRMLPLNLVFPPAYSMFAFVLWRPLILNASSGTRDEVQQLHHSLLLAFGDVIKHLPFREVCLRDTHSLYDLIAADTVDSDFASLLEASGVDLRTKASAFVPLRARLFLNALIDCRIPQPIVKQDDGNQVGVQGESKFHGAENETKLLDKLVYILDTLQPAKFHWQWIELRLLLNEQAVIEKLEGHDLSLVEALRALSPNTDKASVSENESNIIEMILTRLLVRPDAAPLFSEVVHLLGRSLEDSMLLQAKWFLGGHDVLFGRKSVRQRLINIAVSKGLSTRAQYWKPWGWCPSNSDPTTSKGERFKSEVSSIEEGEVVDEGTTLKRPVKGSGHTVDVEGFLVRQQHVTERALVDLILPCLDQASDDSRSTFASDMIKQMNHIEQQINAVTREASKPAGTIASGIESPTTKSSRKGTRGSSPGLARRASGPAETVPPSPVALRASLSLRLQFILRLFPIIYADREPSGRNMRYMLASVILRTLGSRIVHEDASHFFNQAYSSKRELDSLVEASSTASVVMSLESLFDRLLLLLHGLLSSHQPRWLKGKSSSKSSSESSKDYSAFEREGAENLQNELDRMQLPETVRWRIQSAMPILFPSVRWSISCQPPSVAPAALSSLLPSNPISVLHSSNGSNQTQRTPVSLLRTATSVSGKAKHVSSQQENDLEVDPWILLEDGAGSSQSSSNSTLVGGSDNANLKASNWLKGTVRVRRTDLTYIGAVDDDS
Length2275
PositionKinase
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.242
Instability index46.68
Isoelectric point8.91
Molecular weight251752.83
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12365
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     345.28|     118|     587|     595|     724|       1
---------------------------------------------------------------------------
   49-  101 (40.03/17.30)	.........KLKCDKEHLNSRL.....GPP........DFLPQTPNcpeeTLTKEYVQSG....YRETVEGLEEAREIS............................................................................................................................................................................................................................................................................
  289-  368 (44.01/20.93)	...............................................................................lsqvqaftkpvifkckeairkchrainesraqkrkagqvygvpleglqltkpgtfpdqrscgeefrkkwieglsqqhkrlrsladhvphgyrrkslfevlirnnvpllratwfvkvtylnqvrpgsssmssgvpdkthisrseqwtkdvidylqylldefisrnsvhsalhirdrspqmgyagsiqlKSDPTLGTIDCEEPsLHfkwwyvvrilqwhqregllipsLIIDWV.LNQLQEKELLGVLQLLlpVIYGFIDTVVLSQSYVR
  595-  715 (197.95/150.14)	AIYIAVRLLKLKMREAGLSSRL.....REHKIV...KNDYLRTDPG....QLTNYSGRSP....GSGASEPLCYKRRAS..........................................................................................................................................................................................gKCGDFLGMFDSPCP.LH.....................dILVCWIdQHEVQNTEGFKRLQLL..IIELIRAGIFYPQAYVR
  747-  824 (63.30/41.52)	GQYVQDALEEARIAESHVLSEVmnvycNERKLVlhgKIDPYSTTCG......TSYHKHKPrpnsGESLSAPSVDQLRSS...........................................................................................................................................................................................ESGSF............................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.62|      12|      23|    1687|    1698|       2
---------------------------------------------------------------------------
 1687- 1698 (21.54/10.63)	KFHGAENETKLL
 1712- 1723 (25.08/13.45)	KFHWQWIELRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.22|      19|     409|    1743|    1762|       3
---------------------------------------------------------------------------
 1743- 1762 (28.36/20.93)	ALRALSPnTDKASV..SENESN
 2165- 2185 (28.85/16.04)	ALSSLLP.SNPISVlhSSNGSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.14|      21|      27|    1481|    1505|       9
---------------------------------------------------------------------------
 1481- 1505 (33.53/27.89)	LK.DGL.DV.VHFVRSMrsnsNGNARSV
 1508- 1531 (27.61/13.68)	LKaDSLaEVsVHWFRVL....VGNCRTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.67|      16|      17|    1937|    1953|      10
---------------------------------------------------------------------------
 1937- 1953 (21.10/17.87)	INAVTREASKpAGTIAS
 1955- 1970 (27.58/17.35)	IESPTTKSSR.KGTRGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.23|      15|      17|    1856|    1872|      11
---------------------------------------------------------------------------
 1856- 1872 (21.01/18.57)	FKSEVSSieEGEVVD.EG
 1875- 1890 (23.22/13.14)	LKRPVKG..SGHTVDvEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.37|      24|      27|    1987|    2013|      16
---------------------------------------------------------------------------
 1987- 2013 (37.03/31.58)	PSPVALRASLSlrlQFILRLFP..IIYAD
 2016- 2041 (38.34/24.16)	PSGRNMRYMLA...SVILRTLGsrIVHED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12365 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEQQINAVTREASKPAGTIASGIESPTTKSSRKGTRGSSPGLARRASGPAETVP
2) KSSYSQIYPLNPSDDEETWWMRKGQKSIESFRAEPPPKPAKSASKGRQKVVRK
3) LKGSITTLLQLPSSSSTDTGVDESQVSFKKAVVSGSNGMDNSEGTPGCEECRRA
4) SCTSAVNNSTIGGSSARDSSRVESASLPPNF
5) TCGTSYHKHKPRPNSGESLSAPSVDQLRSSESGSFRLSKDAG
1933
901
839
8
790
1986
953
892
38
831










Molecular Recognition Features






MoRF SequenceStartStop




1) GYEELEDGEL
2) KKSKKLAHS
3) SRHKRHRRDHRD
1027
994
1009
1036
1002
1020