<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12361

Description mediator of RNA polymerase II transcription subunit 25-like
SequenceMVADKQLIVAVEGTAALGPFWHTIVSDYLDKIIRSFFGAESTSQKPSAANVEVSLVMFNAHGSYSACLVQRSGWTRDMDIFFQWLSAIPFSGGGFSDAAVAEGLGEALMMFSSPNGNQSQQNMEGKKHCLLISASNPYPLPTPVYRPQMQKLEQNENTETQTDSRLSDAETVAKALPQCSVSLSVICPKQLSKLRAVYNAGKRNPRAADPPIDTAKNPNFLVLISENFIEARAAFSRSGMTNLTSNQTPIKMDVPSIPPVSVPPSISNSAANGSVMSRQPISAGNIPPATVKIEPTTVTSMNGPAFSHIPSVRPALQPVPSLQTSSPLSVSQEMASHNENVQEMKPIVSGMTQSLRPVAAAAANVRILNDVAQARQAIAGATSIGLQSMGGTPMLSSMISSGMASSVPSAQTVFSSGQSGVTTVSGSVPLSGSGQNTQNSAPASFTSTAPSMSGNPNISISQPLSNNQGGISMDGQTVPGMCQGNLPGTQMMPSGTGMNQNMLTGLGATGMPSGTGTMMPTPGISQQGQPGMQPVGNSTGANMPLSQQQTPAALPSAQSKYVKVWEGNLSGQRQGQPVFITRLEGYRSASASESLAANWPPTMQIVRLISQDHMNNKQYVGKADFLVFRAMNQHGFLSQLQEKKLCAVIQLPSQTLLLSVSDKACRLIGMLFPGDMVVFKPQIPSQQQQQQQLQAQHPQLQQQQLSQQQQHLSQLQQQPLQQLQQQQPLMQLQQQQQIPLQQQSQIPQMQQQQIHQM
Length757
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.292
Instability index56.08
Isoelectric point8.87
Molecular weight80855.95
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12361
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     120.02|      16|      16|     703|     718|       1
---------------------------------------------------------------------------
  682-  696 (27.50/ 8.83)	QIPS.QQQQQ.QQLQAQ
  703-  718 (33.62/12.43)	QQLS.QQQQHLSQLQQQ
  721-  735 (32.69/11.89)	QQL..QQQQPLMQLQQQ
  736-  752 (26.22/ 8.07)	QQIPlQQQSQIPQMQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     335.23|      50|      50|     444|     493|       2
---------------------------------------------------------------------------
  255-  288 (39.89/12.12)	......PSI.....PPVS..VPPSI...........SNSAAnGSVMSRQ..P............ISAGNIP......P
  308-  346 (56.05/19.93)	HIPSVRPALQ..PVPSLQ..TSSPL...........SVSQ.......................EMASHNENVQE.MKP
  388-  442 (34.62/ 9.57)	.......SMG..GTPMLSsmISSGMassvpsaqtvfSSGQS.GVTTVSGSVP.............LSGSGQNTQnSAP
  444-  493 (97.28/39.85)	SFTSTAPSMS..GNPNIS..ISQPL...........SNNQG.GISMDGQTVP...........GMCQGNLPGTQ.MMP
  494-  520 (43.23/13.73)	SGTG....M....NQN........M...........LTGLG.A........T...........GMPSGT..GT..MMP
  521-  573 (29.52/ 7.11)	....T.PGISqqGQPGM.....QPV...........GNSTGaNMPLSQQQTPaalpsaqskyvKVWEGNLSGQR....
  583-  618 (34.64/ 9.58)	........LE..GYRSAS..ASESL...........AANWP.P.TM..QIVR...........LISQDHMNNKQ....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12361 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSRSGMTNLTSNQTPIKMDVPSIPPVSVPPSISNSAANGSVMSRQPISAGNIPPATVKIEPTTVTS
2) SVPSAQTVFSSGQSGVTTVSGSVPLSGSGQNTQNSAPASFTSTAPSMSGNPNISISQPLSNNQGGISMDGQTVPGMCQGNLPGTQMMPSGTGMNQNMLTGLGATGMPSGTGTMMPTPGISQQGQPGMQPVGNSTGANMPLSQQQTPAA
3) VRPALQPVPSLQTSSPLSVSQEMASHNENVQEMKPIVSGMTQ
235
406
312
300
553
353










Molecular Recognition Features






MoRF SequenceStartStop




NANANA