<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12359

Description pre-mRNA-processing protein 40A-like isoform X1
SequenceMASNPPPSGPQPLWPPSVGSTPPQGFGSSFPMQFRPAVSTQQGQPFASSISASPQYRPIGQTPNAGMPPGHGQIPQFSQPMQQFPPRPSQPGHGILSSQAIQMPFIQSSMPQPQQVIPPLNSHMPGVSGAGNPFSSSYTFAPPPFAQALSGLNMPSQVQSSSQMHVPPFPSGGQPWLSSGSQTTPVAAPTLLTSQQLSAIAPSVPAGTASQQNASDWQEYEAADGRRYYYNKITKQSSWEKPLELMTTLERADASTVWKEFTTADGRKYYYNKETKQSKWTIPEELKLARELAEISADQVVQTGASTISGVQVTAAVTSTEQPSAVTPASSTPSSTVSGVASSPVPVTSAVSDHASPLVVSGSSAIPAVTPAMPSSSGVSSPAVSGSTGSATLANASQKQMSGFENLSPQVASSLSGASIQDIEEAKKGMAVAGKVNVVPAEEKTTEEEPFLYATKQEAKNAFKALLEFANVESDWTWEQTMRVIINDKRYGALKTLGERKQAFNEYLMQRKKQEAEERRHRQRKAKEEFTKMLEESKELISSTRWSKAVTMFEDDERFKAVEREADREDLFRNYLVDLQKKERAKAQEEYRHNRLEYRQFLETCGFIKVDTQWRKVQDLLEDDERCSRLEKIDRLDIFQEYIRDLEKEDEEQRKLQKEQLRRTERKNRDAFRKMMEEQIAAGTLTAKTSWRDYCQMVKEYVAYQAVASNTSGSTPKDLFEDVVEELEKQYHEDKIRVKDVVKSEKITISSTWTFEDFKAAILEGIGSPSIHDVNLQLIFEDIIERAKEKEEKESKKRQRLAKDFTDKLSTIKEITASSSWEECKELVEDSSEFRAIGEETISRAVFEEYVAWLQEKAKEKERRREEEKAKKEKEKEEKEKRKDKERREKEREKEKEREKEKERGKERSTKDEADSESMDVTDNYEPKEERKREKDKERKHRKRHHISNDEVTSDKDEKVEPERDKERKHRKRHHSSNDEVASDKDEKEESKRSRRHSSDRKKSKKLAHSPESDGESRHKRHRRDHRDGSRRNGGYEELEDGELGEDGES
Length1050
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-1.062
Instability index62.56
Isoelectric point6.14
Molecular weight119113.93
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
U1 snRNP	GO:0005685	IBA:GO_Central
U2-type prespliceosome	GO:0071004	IBA:GO_Central

GO - Biological Function
RNA binding	GO:0003723	IBA:GO_Central

GO - Biological Process
mRNA cis splicing, via spliceosome	GO:0045292	IEA:InterPro
mRNA splicing, via spliceosome	GO:0000398	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12359
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     145.18|      26|      27|     934|     959|       1
---------------------------------------------------------------------------
  512-  528 (21.28/ 6.14)	.......K...KQE......AEER..RHRQRK..AKE
  873-  894 (21.66/ 6.38)	E.....KE...KEEK.ekRKDKER..REKEREK....
  917-  950 (33.69/14.06)	EsmdVTDNyepKEER.krEKDKER..KHRKRHHISND
  951-  979 (44.66/21.06)	E...VTSD...KDEKvepERDKER..KHRKRHHSSND
  980- 1000 (23.89/ 7.81)	E...VASD...KDEK.........eeSKRSRRH.SSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.28|      38|      40|     208|     245|       2
---------------------------------------------------------------------------
  208-  245 (76.15/43.48)	TASQQNASD.WQEYEAADGRRYYYNKITKQSSWEKPLEL
  248-  286 (69.13/38.83)	TLERADASTvWKEFTTADGRKYYYNKETKQSKWTIPEEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     413.63|      62|      66|     529|     590|       3
---------------------------------------------------------------------------
  457-  510 (55.08/25.05)	Q...........EaknaFKALLEF...A.NVESDWTWEQTMRVIINDKRYGALKTLGE...RKQAFNEYLMQ.....................
  529-  589 (93.78/47.09)	............E....FTKMLEE...SKELISSTRWSKAVTMFEDDERFKAVEREAD...REDLFRNYLVDLQ.....K..K...ERAKAQE
  590-  658 (78.80/38.56)	E.....yrhnrlE....YRQFLET...CGFIKVDTQWRKVQDLLEDDERCSRLEK.ID...RLDIFQEYIRDLE.....K..E.deEQRKLQK
  659-  740 (62.09/29.05)	EqlrrterknrdA....FRKMMEEqiaAGTLTAKTSWRDYCQMVKEYVAYQAVASNTSgstPKDLFEDVVEELE.....K..QyheDKIRVKD
  741-  791 (49.33/21.78)	V........vksE...............KITISST.WT.....FED...FKAAILEGI...GSPSIHD..VNLQlifedI..I...ERAKEKE
  792-  866 (74.53/36.13)	EkeskkrqrlakD....FTDKLST...IKEITASSSWEECKELVEDSSEFRAIGEETI...SRAVFEEYVAWLQ.....EkaK...EKERRRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     193.31|      26|      26|      66|      91|       4
---------------------------------------------------------------------------
    5-   34 (37.76/18.03)	PP.PSgpQP....L........WPPSV.GSTPPqgFgsSFPMQ.F
   62-   84 (33.81/15.33)	.......TP..naG........MPPGH.GQIPQ..F..SQPMQQF
   85-  116 (34.94/16.10)	PPRPS..QP..ghGilssqaiqMPFIQ.SSMP.......QP.QQV
  117-  141 (29.69/12.51)	IP......P.lnsH........MPGVS.GAGNP..F..SSSYTFA
  142-  166 (29.48/12.37)	PPPFA..QAlsglN........MP....SQVQS..S..SQ..MHV
  167-  184 (27.63/11.10)	PPFPS......................gGQ.PW..L..SSGSQTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.07|      27|      28|     377|     403|       5
---------------------------------------------------------------------------
  309-  339 (30.39/13.18)	SGVQvTAAVTSTEQPSAVTP..ASStpsSTVSG
  377-  403 (45.47/23.03)	SGVS.SPAVSGSTGSATLAN..ASQ...KQMSG
  405-  430 (22.22/ 7.85)	ENLS..PQVASSLSGASIQDieEAK...KGM..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12359 with Med35 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KERRREEEKAKKEKEKEEKEKRKDKERREKEREKEKEREKEKERGKERSTKDEADSESMDVTDNYEPKEERKREKDKERKHRKRHHISNDEVTSDKDEKVEPERDKERKHRKRHHSSNDEVASDKDEKEESKRSRRHSSDRKKSKKLAHSPESDGESRHKRHRRDHRDGSRRNGGYEELEDGELGEDGES
2) LSGLNMPSQVQSSSQMHVPPFPSGGQPWLSSGSQTTP
3) MASNPPPSGPQPLWPPSVGSTPPQGFGSSFPMQFRPAVSTQQGQPFASSISASPQYRPIGQTPNAGMPPGHGQIPQFSQPMQQFPPRPSQPGHGILSSQAIQMPFIQSSMPQPQQVIPPLNSHMPGVSGAGNPFSSSYTF
4) VQVTAAVTSTEQPSAVTPASSTPSSTVSGVASSPVPVT
861
149
1
311
1050
185
140
348










Molecular Recognition Features






MoRF SequenceStartStop




1) GYEELEDGEL
2) KKSKKLAHS
3) SRHKRHRRDHRD
1035
1002
1017
1044
1010
1028