<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12351

Description mediator of RNA polymerase II transcription subunit 19a-like isoform X2
SequenceMDSDSKNFGRGPRELTDTHYLHNVVGDREIRKGEGMQLDQLTQDTSFSREIKSCIRPFDLDVLREAFQLRETAPVDLSPSEKGIPTIAGKSKSEMKDKEKKHKKHKDKDKEKDKEHKKHKHRHKDRSKEKKKDKSGHHDPGAEHSKKHEKKRKHDEEDLNGVHKHKKSKHKSSKIDEIGAIKVAV
Length185
PositionHead
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-1.628
Instability index39.05
Isoelectric point9.60
Molecular weight21452.96
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12351
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.03|      16|      40|     121|     136|       2
---------------------------------------------------------------------------
  121-  136 (28.23/ 9.85)	HRHKDRSKEK..KKDKSG
  143-  158 (26.14/ 8.61)	EHSKKHEKKR..KHDEED
  163-  179 (22.66/ 6.54)	HKHK.KSKHKssKIDEIG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12351 with Med19 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAFQLRETAPVDLSPSEKGIPTIAGKSKSEMKDKEKKHKKHKDKDKEKDKEHKKHKHRHKDRSKEKKKDKSGHHDPGAEHSKKHEKKRKHDEEDLNGVHKHKKSKHKSSKIDEIGAIKVAV
2) MDSDSKNFGRGPRELTDTHYLHNVVGDREIRKGEGMQLDQLTQDTSFSRE
65
1
185
50










Molecular Recognition Features






MoRF SequenceStartStop




1) FGRGPRE
2) KGIPTIAGKSKSEMKDKEKKHKKHKDKDKEKDKEHKKHKHRHKDRSKEKKKDKSGHHDPGAEHSKKHEKKRKHDEEDLNGVHKHKKS
3) KIDEIG
4) NVVGDR
8
82
174
23
14
168
179
28