<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12334

Description luminal-binding protein 4
SequenceMAGGAWNRRTSLIVFGIVLFGCLFAFSIATEEATKLGTVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVAFTDGERLIGEAAKNLAAVNPERTIFDVKRLIGRKFDDKEVQRDMKLVPYKIVNKDGKPYIQVKIKDGETKIFSPEEISAMILTKMKETAEAYLGKKIKDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKKGGEKNILVFDLGGGTFDVSILTIDNGVFEVLSTNGDTHLGGEDFDQRIMEYFIKLIKKKHGKDISKDNRALGKLRREAERAKRALSSQHQVRVEIESLFDGVDFSEPLTRARFEELNNDLFRKTMGPVKKAMDDAGLEKTQIDEIVLVGGSTRIPKVQQLLKDYFDGKEPNKGVNPDEAVAYGAAVQGGILSGEGGDETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVTIQVFEGERSLTKDCRLLGKFDLTGIAPAPRGTPQIEVTFEVDANGILNVKAEDKASGKSEKITITNDKGRLSQEEIERMVKEAEEFAEEDKKVKERIDARNSLETYVYNMRNQINDKDKLADKLESDEKEKIETATKEALEWLDDNQSAEKEDYEEKLKEVEAVCNPIITAVYQKSGGAPGGESGASEDDDHDEL
Length667
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.06
Grand average of hydropathy-0.437
Instability index27.91
Isoelectric point5.07
Molecular weight73535.43
Publications
PubMed=1822990
PubMed=24807620

Function

Annotated function Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. 
GO - Cellular Component
cytoplasm	GO:0005737	IBA:GO_Central
endoplasmic reticulum chaperone complex	GO:0034663	IBA:GO_Central
endoplasmic reticulum lumen	GO:0005788	IBA:GO_Central
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
membrane	GO:0016020	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IBA:GO_Central
ATPase activity	GO:0016887	IBA:GO_Central
heat shock protein binding	GO:0031072	IBA:GO_Central
misfolded protein binding	GO:0051787	IBA:GO_Central
protein folding chaperone	GO:0044183	IBA:GO_Central
unfolded protein binding	GO:0051082	IBA:GO_Central

GO - Biological Process
cellular response to unfolded protein	GO:0034620	IBA:GO_Central
chaperone cofactor-dependent protein refolding	GO:0051085	IBA:GO_Central
endoplasmic reticulum unfolded protein response	GO:0030968	IBA:GO_Central
protein refolding	GO:0042026	IBA:GO_Central
ubiquitin-dependent ERAD pathway	GO:0030433	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12334
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.28|      16|      16|     187|     202|       1
---------------------------------------------------------------------------
  187-  202 (26.41/17.82)	AQRQATKDAGVIA.GLN
  204-  220 (21.87/13.49)	ARIINEPTAAAIAyGLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.89|      28|     245|     385|     425|       2
---------------------------------------------------------------------------
  111-  146 (46.60/21.82)	FDDKEvqrdmklvPYKIVNKDGK.PY...IQVKIKDG....ETK
  387-  422 (38.30/42.24)	FDGKE........PNKGVNPDEAvAYgaaVQGGILSGeggdETK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.30|      11|      27|     233|     243|       3
---------------------------------------------------------------------------
  233-  243 (20.46/12.67)	LGGGTFDVSIL
  261-  271 (21.85/14.07)	LGGEDFDQRIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.13|      26|      27|     575|     601|       5
---------------------------------------------------------------------------
  575-  601 (38.52/28.27)	LETYVYNMRNQINDkDKLADKLESDEK
  604-  629 (42.61/26.77)	IETATKEALEWLDD.NQSAEKEDYEEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.40|      17|      21|      68|      85|       7
---------------------------------------------------------------------------
   68-   85 (28.46/23.70)	N..RITPSWVAFtDGERLIG
   90-  108 (25.94/16.02)	NlaAVNPERTIF.DVKRLIG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12334 with Med37 domain of Kingdom Viridiplantae
Unable to open file!