<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12326

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQISWFQFLPHESDVSSLVDKSVKLDKKDAATWLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFLPGQHSSVVEKAQSAVSKLRVLASGLWVAPGDSEEVAAALSQALRNCMERKLRGLSYVRYGDVFTRHHPFSQNEELFRKGQPVLEFIFSATEEAIFVHVIISAKHIRALSSGDIDKISEDTSNVSGERLPVIVSPHGMRGRLTGCCPADLVKQVYLSSCKFSASNGIVGLPCNVSRSGFQLKGQNCYVEVSLGCTTPGNNNIKESSRMLIYPPEAILVPVVQTACARSSLKRFWLQNWIGPSLSFTSSFMHCFDFNSDAKVNSTDGSWLDANITRSNRHYNSSSNSNSSSVSSVSTSSSDSDYKISGAGDLEADADSLMCRPSGLSSVDQSQNDNLKAGFKRSRTGISESFSQAGAVINPSTSDYASMEVNNSAITGGNDQIGLQWGWDDDDRGVGMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMFPAADSADVGSSPCPSMMDVQDQMLLPVGFPSFDSFNQPPPPASLDDSLGKQQEVIKSTAVANQVNNASAAIAGEFDHLIKAEALMTFAPEYGAVETPTGEKPHSIFRNPYLPKSREVDTSNSSSNSYVYSATPPLSPCFDACEEKSGVTVNLKTGAGKRDTSSIIQSKRYYTHIESGKQKNDGKLCGSDHSCATREAQVAQSPFYGFNSTNSVKSIHNKTQKANEVLLKADSFGQSMKTVLATEVECLMCQAFMCKIRHTLLSSSSYLPVGASRMSGSTIINQPQGEAVVTVDNLSSKSEMKKKEIIPVRIAGDIDGGLLDGTLNAPVGVWRSVGVSKGMKQPSSALEACHSVQHNSFIEESMLAYGLRQPLQELLDGMALLVQQATSLVDVALDADNNDGPYGWLALQEQWRRGFSCGPSMVHAGCGGVLASCHSLDIAGVELIDPLSADVQASFTLTLLQNDIKTAMKSAFGTMEGPLSVVDWCKGRSQSNDGGISGDGFSAESTASASECRDSSSTISFSVGEPISPSQSSAGGSSLKDGIRVDEASERRLSQDTCLSESEQLPGSRLRPTLSAVPYPAILVGYQDDWLKTSPSSLQLWEKAPFEPYAMPKHMSYYVVCPDINALTTAATDFFQQLGTVYETCKLGTHSPQCMGNEMEIDSGKNVSSGFVLIDCPQSMKIDSSSTSMLGSISDYFLSLSNGWDLESYLKSLSKVLRNLKLSSCMTMNPKEGSTGPCTVIYVVCPFPEPLAVLQTVVESSIAVGSVVLSSDKERRSTLQNQVGKALSYSAAVDESLSNVLTLSGFCIPKLVLQIVTVDAIFRVTSPALSELLVLKEIAFTVYNKARRISRGSSSDMVQSSSMSGRSHPVLMQMTSPVPGMWKDCVGPRSIGTSLQREAELDASLRSGSWDNWQTSRGGSLGCDPNRIGDFSIQDEVRYLFEPLYILAEPGSLDRGLSFPMSGNLMAESSKLLLDDGTSGNFMQSSASSGGGDTGPNTQSETSEPDGSGSAHQKSLPSLHCCYGWTEDWRWLVCIWTDSRGELLDNYIYPFGGISSRQDTKGLQSLFVQILQQGCQILQACPPESAIAKPRDFVIARIGSFFELECQEWQKALYAIGGSEVKKWSLQLRRSVPDGMSASSNGASLQQQEIGGMGQPSTRKQLIGGQGMVDNSRGLLQWVQSISFVSVSIDHSLQLMLQADIVSHGTSQSSGVLSQPGYLEGYTPVKSLGSTSTSYILIPSPNMRFLPPVGLQLRTCLTAESPPLAHLLHSKGCAIPLSTGFVVSKAVPTMRRDARGISKEEWPSVLSVGLVDYYGGSNIIQEKFLKGVGKVGGRGASSETRDVEVETHLILENIAAELHALSWMTVSPAYLERRSALPFHCDMVLRLRRLLHFADKEVSRQPEKTQV
Length1930
PositionKinase
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.210
Instability index53.43
Isoelectric point5.42
Molecular weight208629.88
Publications
PubMed=24807620

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP12326
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.50|      20|      45|     416|     435|       1
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  416-  435 (34.82/18.89)	VDQSQ....ND..NLKAGFKRSRTGI
  458-  483 (28.68/14.29)	VNNSAitggNDqiGLQWGWDDDDRGV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     353.80|     115|     124|    1417|    1539|       2
---------------------------------------------------------------------------
 1417- 1539 (181.11/124.28)	SLQREAELDASLRsgsW..DNWQTSRGGSLGCDPNRIGDFSIQDEVRYLfEPLYI.LAEPGSLDRGLSFPMSGnlMAESSKLLLddGTSGNFMQ......SSA..SSGGGDTGP.NTQSETSEPDG.SGSAHQKSL
 1541- 1668 (172.69/97.84)	SLHCCYGWTEDWR...WlvCIWTDSRGELLDNYIYPFGGISSRQDTKGL.QSLFVqILQQGCQILQACPPESA..IAKPRDFVI..ARIGSFFElecqewQKAlyAIGGSEVKKwSLQLRRSVPDGmSASSNGASL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.66|      17|     126|    1128|    1145|       4
---------------------------------------------------------------------------
 1128- 1145 (33.51/25.78)	PFEPYAMPKHMsYYVVCP
 1253- 1269 (35.16/22.02)	PKEGSTGPCTV.IYVVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     176.75|      40|     827|     376|     415|       6
---------------------------------------------------------------------------
  376-  415 (68.93/37.30)	SSSVSSVSTS..SSDSDY..KISGAG.DLEADADSL..MCRPSGLSS
 1005- 1036 (34.26/13.99)	...VDWCKGR..SQSNDG..GISGDGfSAESTASAS..ECR......
 1038- 1059 (22.52/ 6.09)	SSSTISFSVG..EPISPS..QSSAGG.....................
 1202- 1247 (51.05/25.28)	SMKIDSSSTSmlGSISDYflSLSNGW.DLESYLKSLskVLRNLKLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     331.71|      93|    1112|     563|     657|       7
---------------------------------------------------------------------------
  563-  657 (146.13/97.67)	PASLDDSLGKQQEVIKSTAVANQVNNASaAIAGEFDHLIKaEALMTFAPEY....GAVETPTGEKPHSIFRNP.Y.LPKSREVDTSNSSSNSYVYSATPPL
 1148- 1200 (46.20/22.14)	.........................................NALTTAATDFfqqlGTVYETCKLGTHS....P.QcMGNEMEIDSGKNVSSGFVLIDCP..
 1679- 1766 (139.37/85.21)	PSTRKQLIGGQGMVDNSRGLLQWVQSIS.FVSVSIDHSLQ...LMLQA.......DIVSHGTSQS.SGVLSQPgY.LEGYTPVKSLGSTSTSYILIPSPNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.38|      39|    1112|     180|     218|       8
---------------------------------------------------------------------------
  180-  218 (64.85/41.12)	EEAIF......V.H...........VIISA.KHIRALSSGDIDK.......ISEDTSNV...SGERLP
 1282- 1332 (40.00/22.06)	ESSIA......VgS...........VVLSSdKERRSTLQNQVGKalsysaaVDESLSNVltlSGFCIP
 1341- 1392 (41.52/23.23)	VDAIFrvtspaL.SellvlkeiaftVYNKA.RRISRGSSSDMVQ...........SSSM...SGRSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     170.28|      44|      78|     831|     875|       9
---------------------------------------------------------------------------
  831-  875 (73.31/49.37)	VRIAGDIDGGLLDGTLN..APVGVWRSvGVSKGMKQPSSALEACHSV
  881-  910 (30.02/13.62)	......IEESMLAYGLR..QPLQELLD.GMALLVQQATS........
  912-  952 (66.95/40.46)	VDVALDADNN..DGPYGwlALQEQWRR.GFSCG...PSMVHAGCGGV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12326 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA