Description | mediator of RNA polymerase II transcription subunit 21-like isoform X1 |
Sequence | MDIISQLQEQVNTIAALAFNTFGTLQRDAPPVRLSPNYPEPPPANPTEDAANVAEQPKQMSAAFVKAAKQFDALVAALPLSDGGEEAQLKRIAELQAENDAVGQELQKQLEAAEKELKQVQELFNQATDNCLNLKKPE |
Length | 138 |
Position | Middle |
Organism | Nicotiana tabacum (Common tobacco) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.500 |
Instability index | 60.33 |
Isoelectric point | 4.51 |
Molecular weight | 15024.70 |
Publications | PubMed=24807620 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP12323 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 94.03| 26| 27| 72| 97| 1 --------------------------------------------------------------------------- 44- 67 (18.31/ 6.67) .....ANPTEDAANVAeQPKQMsaAFV..KA 72- 97 (41.58/23.11) DALVAALPLSDGGEEA.QLKRI..AEL..QA 100- 127 (34.14/17.85) DAVGQELQKQLEAAEK.ELKQV..QELfnQA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EDAANVAEQPKQMSAAFVKAAKQFDALVAALPL 2) EEAQLKRIAELQAENDAV 3) VRLSPNYPEP | 48 85 32 | 80 102 41 |
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