<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12321

Description mediator of RNA polymerase II transcription subunit 8-like isoform X1
SequenceMEGAQDQQQQQPPRVAEGLNPAVQQQLNLESVKTRAISLFKAISRILEDFDAIARTNAVPKWQDILGQFSMVNLELFNIVEDIKKVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAKREQLLHSMQNLSVASQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQESLLRTAVNHGEGLRVPGDQRHITSALPGHLVDVLTITDGPQSFADSSGTYLKNTPPFSSSNVNSQGALLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLLPRTQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
Length528
PositionHead
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.606
Instability index59.24
Isoelectric point9.32
Molecular weight57954.62
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12321
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.66|      16|      23|     472|     491|       3
---------------------------------------------------------------------------
  300-  319 (28.69/ 7.79)	NMM.NTPS..PqqqsLQQQQQQQ
  472-  490 (25.97/16.48)	NMGgNNPGmmP....IQQQQQHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.72|      13|      16|     346|     360|       4
---------------------------------------------------------------------------
  346-  359 (20.19/ 7.48)	QLLAQQQLrQASMP
  363-  375 (26.53/ 8.92)	QLHGQPQM.QFSQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.10|      12|      17|     376|     392|       5
---------------------------------------------------------------------------
  382-  400 ( 7.05/13.45)	QGRQLASgaiHhgMgqSQL
  402-  413 (24.05/11.52)	QGNQLNR...H..L..NQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.29|      11|      16|     494|     504|       8
---------------------------------------------------------------------------
  494-  504 (19.71/ 8.42)	NMSQNTQNLQQ
  511-  521 (21.58/ 9.88)	NTPQTHPSFQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.90|      16|      17|     420|     435|       9
---------------------------------------------------------------------------
  420-  433 (18.62/ 7.17)	.....ALFNSAQSTPNSQM
  434-  452 (20.55/ 8.64)	ISnmsAMMTSQTLLPRTQF
  454-  470 (19.73/ 8.01)	IS..gGTRNLAAANLSDQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12321 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLLPRTQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
262
528










Molecular Recognition Features






MoRF SequenceStartStop




NANANA